View in EDS

A Genome-Wide Association Study of Chinese and English Language Phenotypes in Hong Kong Chinese Children

Saved in:
Bibliographic Details
Title: A Genome-Wide Association Study of Chinese and English Language Phenotypes in Hong Kong Chinese Children
Language: English
Authors: Yu-Ping Lin (ORCID 0000-0002-9546-3889), Yujia Shi, Ruoyu Zhang (ORCID 0000-0002-6089-7476), Xiao Xue, Shitao Rao, Liangying Yin, Kelvin Fai Hong Lui, Dora Jue Pan (ORCID 0000-0001-9764-6454), Urs Maurer (ORCID 0000-0002-4156-8597), Kwong-Wai Choy, Silvia Paracchini (ORCID 0000-0001-9934-8602), Catherine McBride, Hon-Cheong So (ORCID 0000-0002-7102-833X)
Source: npj Science of Learning. 2024 9.
Availability: Nature Portfolio. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://www.nature.com/npjscilearn/
Peer Reviewed: Y
Page Count: 18
Publication Date: 2024
Document Type: Journal Articles
Reports - Research
Descriptors: Genetics, Phenomenology, Chinese, Foreign Countries, Children, Dyslexia, Language Impairments, English Language Learners, English (Second Language), Bilingualism, Correlation, Biological Influences, Reading Skills, Neuropsychology
Geographic Terms: Hong Kong
DOI: 10.1038/s41539-024-00229-7
ISSN: 2056-7936
Abstract: Dyslexia and developmental language disorders are important learning difficulties. However, their genetic basis remains poorly understood, and most genetic studies were performed on Europeans. There is a lack of genome-wide association studies (GWAS) on literacy phenotypes of Chinese as a native language and English as a second language (ESL) in a Chinese population. In this study, we conducted GWAS on 34 reading/language-related phenotypes in Hong Kong Chinese bilingual children (including both twins and singletons; total N = 1046). We performed association tests at the single-variant, gene, and pathway levels. In addition, we tested genetic overlap of these phenotypes with other neuropsychiatric disorders, as well as cognitive performance (CP) and educational attainment (EA) using polygenic risk score (PRS) analysis. Totally 5 independent loci (LD-clumped at r[superscript 2] = 0.01; MAF > 0.05) reached genome-wide significance (p < 5e-08; filtered by imputation quality metric Rsq>0.3 and having at least 2 correlated SNPs (r[superscript 2] > 0.5) with p < 1e-3). The loci were associated with a range of language/literacy traits such as Chinese vocabulary, character and word reading, and rapid digit naming, as well as English lexical decision. Several SNPs from these loci mapped to genes that were reported to be associated with EA and other neuropsychiatric phenotypes, such as "MANEA" and "PLXNC1." In PRS analysis, EA and CP showed the most consistent and significant polygenic overlap with a variety of language traits, especially English literacy skills. To summarize, this study revealed the genetic basis of Chinese and English abilities in a group of Chinese bilingual children. Further studies are warranted to replicate the findings.
Abstractor: As Provided
Entry Date: 2024
Accession Number: EJ1431854
Database: ERIC
FullText Text:
  Availability: 0
Header DbId: eric
DbLabel: ERIC
An: EJ1431854
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: A Genome-Wide Association Study of Chinese and English Language Phenotypes in Hong Kong Chinese Children
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yu-Ping+Lin%22&quot;&gt;Yu-Ping Lin&lt;/searchLink&gt; (ORCID &lt;externalLink term=&quot;http://orcid.org/0000-0002-9546-3889&quot;&gt;0000-0002-9546-3889&lt;/externalLink&gt;)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yujia+Shi%22&quot;&gt;Yujia Shi&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ruoyu+Zhang%22&quot;&gt;Ruoyu Zhang&lt;/searchLink&gt; (ORCID &lt;externalLink term=&quot;http://orcid.org/0000-0002-6089-7476&quot;&gt;0000-0002-6089-7476&lt;/externalLink&gt;)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xiao+Xue%22&quot;&gt;Xiao Xue&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shitao+Rao%22&quot;&gt;Shitao Rao&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Liangying+Yin%22&quot;&gt;Liangying Yin&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kelvin+Fai+Hong+Lui%22&quot;&gt;Kelvin Fai Hong Lui&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Dora+Jue+Pan%22&quot;&gt;Dora Jue Pan&lt;/searchLink&gt; (ORCID &lt;externalLink term=&quot;http://orcid.org/0000-0001-9764-6454&quot;&gt;0000-0001-9764-6454&lt;/externalLink&gt;)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Urs+Maurer%22&quot;&gt;Urs Maurer&lt;/searchLink&gt; (ORCID &lt;externalLink term=&quot;http://orcid.org/0000-0002-4156-8597&quot;&gt;0000-0002-4156-8597&lt;/externalLink&gt;)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kwong-Wai+Choy%22&quot;&gt;Kwong-Wai Choy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Silvia+Paracchini%22&quot;&gt;Silvia Paracchini&lt;/searchLink&gt; (ORCID &lt;externalLink term=&quot;http://orcid.org/0000-0001-9934-8602&quot;&gt;0000-0001-9934-8602&lt;/externalLink&gt;)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Catherine+McBride%22&quot;&gt;Catherine McBride&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hon-Cheong+So%22&quot;&gt;Hon-Cheong So&lt;/searchLink&gt; (ORCID &lt;externalLink term=&quot;http://orcid.org/0000-0002-7102-833X&quot;&gt;0000-0002-7102-833X&lt;/externalLink&gt;)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;SO&quot; term=&quot;%22npj+Science+of+Learning%22&quot;&gt;&lt;i&gt;npj Science of Learning&lt;/i&gt;&lt;/searchLink&gt;. 2024 9.
– Name: Avail
  Label: Availability
  Group: Avail
  Data: Nature Portfolio. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://www.nature.com/npjscilearn/
– Name: PeerReviewed
  Label: Peer Reviewed
  Group: SrcInfo
  Data: Y
– Name: Pages
  Label: Page Count
  Group: Src
  Data: 18
– Name: DatePubCY
  Label: Publication Date
  Group: Date
  Data: 2024
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: Journal Articles&lt;br /&gt;Reports - Research
– Name: Subject
  Label: Descriptors
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Genetics%22&quot;&gt;Genetics&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Phenomenology%22&quot;&gt;Phenomenology&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Chinese%22&quot;&gt;Chinese&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Foreign+Countries%22&quot;&gt;Foreign Countries&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Children%22&quot;&gt;Children&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Dyslexia%22&quot;&gt;Dyslexia&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Language+Impairments%22&quot;&gt;Language Impairments&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22English+Language+Learners%22&quot;&gt;English Language Learners&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22English+%28Second+Language%29%22&quot;&gt;English (Second Language)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Bilingualism%22&quot;&gt;Bilingualism&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Correlation%22&quot;&gt;Correlation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Biological+Influences%22&quot;&gt;Biological Influences&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Reading+Skills%22&quot;&gt;Reading Skills&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Neuropsychology%22&quot;&gt;Neuropsychology&lt;/searchLink&gt;
– Name: Subject
  Label: Geographic Terms
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Hong+Kong%22&quot;&gt;Hong Kong&lt;/searchLink&gt;
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1038/s41539-024-00229-7
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 2056-7936
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Dyslexia and developmental language disorders are important learning difficulties. However, their genetic basis remains poorly understood, and most genetic studies were performed on Europeans. There is a lack of genome-wide association studies (GWAS) on literacy phenotypes of Chinese as a native language and English as a second language (ESL) in a Chinese population. In this study, we conducted GWAS on 34 reading/language-related phenotypes in Hong Kong Chinese bilingual children (including both twins and singletons; total N = 1046). We performed association tests at the single-variant, gene, and pathway levels. In addition, we tested genetic overlap of these phenotypes with other neuropsychiatric disorders, as well as cognitive performance (CP) and educational attainment (EA) using polygenic risk score (PRS) analysis. Totally 5 independent loci (LD-clumped at r[superscript 2] = 0.01; MAF &gt; 0.05) reached genome-wide significance (p &lt; 5e-08; filtered by imputation quality metric Rsq&gt;0.3 and having at least 2 correlated SNPs (r[superscript 2] &gt; 0.5) with p &lt; 1e-3). The loci were associated with a range of language/literacy traits such as Chinese vocabulary, character and word reading, and rapid digit naming, as well as English lexical decision. Several SNPs from these loci mapped to genes that were reported to be associated with EA and other neuropsychiatric phenotypes, such as &quot;MANEA&quot; and &quot;PLXNC1.&quot; In PRS analysis, EA and CP showed the most consistent and significant polygenic overlap with a variety of language traits, especially English literacy skills. To summarize, this study revealed the genetic basis of Chinese and English abilities in a group of Chinese bilingual children. Further studies are warranted to replicate the findings.
– Name: AbstractInfo
  Label: Abstractor
  Group: Ab
  Data: As Provided
– Name: DateEntry
  Label: Entry Date
  Group: Date
  Data: 2024
– Name: AN
  Label: Accession Number
  Group: ID
  Data: EJ1431854
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=eric&AN=EJ1431854
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41539-024-00229-7
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 18
    Subjects:
      – SubjectFull: Genetics
        Type: general
      – SubjectFull: Phenomenology
        Type: general
      – SubjectFull: Chinese
        Type: general
      – SubjectFull: Foreign Countries
        Type: general
      – SubjectFull: Children
        Type: general
      – SubjectFull: Dyslexia
        Type: general
      – SubjectFull: Language Impairments
        Type: general
      – SubjectFull: English Language Learners
        Type: general
      – SubjectFull: English (Second Language)
        Type: general
      – SubjectFull: Bilingualism
        Type: general
      – SubjectFull: Correlation
        Type: general
      – SubjectFull: Biological Influences
        Type: general
      – SubjectFull: Reading Skills
        Type: general
      – SubjectFull: Neuropsychology
        Type: general
      – SubjectFull: Hong Kong
        Type: general
    Titles:
      – TitleFull: A Genome-Wide Association Study of Chinese and English Language Phenotypes in Hong Kong Chinese Children
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Yu-Ping Lin
      – PersonEntity:
          Name:
            NameFull: Yujia Shi
      – PersonEntity:
          Name:
            NameFull: Ruoyu Zhang
      – PersonEntity:
          Name:
            NameFull: Xiao Xue
      – PersonEntity:
          Name:
            NameFull: Shitao Rao
      – PersonEntity:
          Name:
            NameFull: Liangying Yin
      – PersonEntity:
          Name:
            NameFull: Kelvin Fai Hong Lui
      – PersonEntity:
          Name:
            NameFull: Dora Jue Pan
      – PersonEntity:
          Name:
            NameFull: Urs Maurer
      – PersonEntity:
          Name:
            NameFull: Kwong-Wai Choy
      – PersonEntity:
          Name:
            NameFull: Silvia Paracchini
      – PersonEntity:
          Name:
            NameFull: Catherine McBride
      – PersonEntity:
          Name:
            NameFull: Hon-Cheong So
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-electronic
              Value: 2056-7936
          Numbering:
            – Type: volume
              Value: 9
          Titles:
            – TitleFull: npj Science of Learning
              Type: main
ResultId 1