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A Multidisciplinary Team-Based Classroom Exercise for Small Molecule Drug Discovery

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Title: A Multidisciplinary Team-Based Classroom Exercise for Small Molecule Drug Discovery
Language: English
Authors: Charlotte A. Dodson (ORCID 0000-0002-8403-726X), Stephen E. Flower (ORCID 0000-0003-2659-3118), Mark Thomas
Source: Journal of Chemical Education. 2023 100(9):3320-3332.
Availability: Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Peer Reviewed: Y
Page Count: 13
Publication Date: 2023
Document Type: Journal Articles
Reports - Descriptive
Education Level: Higher Education
Postsecondary Education
Descriptors: Drug Therapy, Pharmacy, Teamwork, Interdisciplinary Approach, Graduate Students, Workshops, Scientific Research, Molecular Structure, Decision Making, Data Analysis, Industry, Undergraduate Students, Organic Chemistry, Biochemistry, Problem Solving, Computer Software, Teaching Methods, Computer Simulation
ISSN: 0021-9584
1938-1328
Abstract: Industrial drug discovery teams encompass scientists from multiple specialties and require participants to communicate effectively across disciplinary boundaries. In this paper, we present an undergraduate or graduate classroom simulation of this environment. Over a series of five workshops, student teams of mixed scientific backgrounds perform five iterations of the chemistry cycle of small molecule drug discovery. Students analyze physicochemical, structural, and (fictional) assay data and use these to design new compounds for testing. Simulated assay results are returned to students who use the information in the design of subsequent compounds. After workshop 5, each team selects a single lead compound, supported by a potential synthetic route, a portfolio of assay data, and logical scientific decision-making. Our exercise provides students with opportunities for hands-on student-responsive data handing, team-building, and technical knowledge acquisition--all within an industrially relevant scientific scenario.
Abstractor: As Provided
Entry Date: 2024
Accession Number: EJ1444492
Database: ERIC
FullText Text:
  Availability: 0
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  Data: A Multidisciplinary Team-Based Classroom Exercise for Small Molecule Drug Discovery
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  Data: <searchLink fieldCode="AR" term="%22Charlotte+A%2E+Dodson%22">Charlotte A. Dodson</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0002-8403-726X">0000-0002-8403-726X</externalLink>)<br /><searchLink fieldCode="AR" term="%22Stephen+E%2E+Flower%22">Stephen E. Flower</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0003-2659-3118">0000-0003-2659-3118</externalLink>)<br /><searchLink fieldCode="AR" term="%22Mark+Thomas%22">Mark Thomas</searchLink>
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  Data: <searchLink fieldCode="SO" term="%22Journal+of+Chemical+Education%22"><i>Journal of Chemical Education</i></searchLink>. 2023 100(9):3320-3332.
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  Data: Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
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  Data: 13
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  Data: Industrial drug discovery teams encompass scientists from multiple specialties and require participants to communicate effectively across disciplinary boundaries. In this paper, we present an undergraduate or graduate classroom simulation of this environment. Over a series of five workshops, student teams of mixed scientific backgrounds perform five iterations of the chemistry cycle of small molecule drug discovery. Students analyze physicochemical, structural, and (fictional) assay data and use these to design new compounds for testing. Simulated assay results are returned to students who use the information in the design of subsequent compounds. After workshop 5, each team selects a single lead compound, supported by a potential synthetic route, a portfolio of assay data, and logical scientific decision-making. Our exercise provides students with opportunities for hands-on student-responsive data handing, team-building, and technical knowledge acquisition--all within an industrially relevant scientific scenario.
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  Data: 2024
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  Data: EJ1444492
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    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 13
        StartPage: 3320
    Subjects:
      – SubjectFull: Drug Therapy
        Type: general
      – SubjectFull: Pharmacy
        Type: general
      – SubjectFull: Teamwork
        Type: general
      – SubjectFull: Interdisciplinary Approach
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      – SubjectFull: Graduate Students
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      – SubjectFull: Workshops
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      – SubjectFull: Scientific Research
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      – SubjectFull: Molecular Structure
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      – SubjectFull: Decision Making
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      – SubjectFull: Data Analysis
        Type: general
      – SubjectFull: Industry
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      – SubjectFull: Undergraduate Students
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      – SubjectFull: Organic Chemistry
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      – SubjectFull: Biochemistry
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      – SubjectFull: Problem Solving
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      – SubjectFull: Computer Software
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      – SubjectFull: Teaching Methods
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      – SubjectFull: Computer Simulation
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    Titles:
      – TitleFull: A Multidisciplinary Team-Based Classroom Exercise for Small Molecule Drug Discovery
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              Y: 2023
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