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The Impact of the COVID-19 Pandemic on Alcohol Use Disorder Symptoms: Testing Interactions with Polygenic Risk

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Bibliographic Details
Title: The Impact of the COVID-19 Pandemic on Alcohol Use Disorder Symptoms: Testing Interactions with Polygenic Risk
Language: English
Authors: Kaitlin E. Bountress, Daniel Bustamante, Mohammad Ahangari, Fazil Aliev, Steven H. Aggen, Eva Lancaster, The Spit for Science Working Group, Roseann E. Peterson, Jasmin Vassileva, Danielle M. Dick, Ananda B. Amstadter
Source: Journal of American College Health. 2025 73(4):1532-1537.
Availability: Taylor & Francis. Available from: Taylor & Francis, Ltd. 530 Walnut Street Suite 850, Philadelphia, PA 19106. Tel: 800-354-1420; Tel: 215-625-8900; Fax: 215-207-0050; Web site: http://www.tandf.co.uk/journals
Peer Reviewed: Y
Page Count: 6
Publication Date: 2025
Sponsoring Agency: National Institute on Alcohol Abuse and Alcoholism (NIAAA) (DHHS/NIH)
National Center for Research Resources (NCRR) (DHHS/NIH)
National Center for Advancing Translational Sciences (NCATS) (DHHS/NIH), Clinical and Translational Science Awards (CTSA) Program
Contract Number: P20AA017828
R37AA011408
Document Type: Journal Articles
Reports - Research
Education Level: Higher Education
Postsecondary Education
Descriptors: COVID-19, Pandemics, Alcohol Abuse, Symptoms (Individual Disorders), Substance Abuse, Longitudinal Studies, Genetics, Prediction, College Students, Hunger, Housing, At Risk Persons, Correlation, Measures (Individuals)
Geographic Terms: Virginia
DOI: 10.1080/07448481.2024.2308255
ISSN: 0744-8481
1940-3208
Abstract: Objective: The purpose of this study was to test whether COVID impact interacts with genetic risk (polygenic risk score/PRS) to predict alcohol use disorder (AUD) symptoms. Method: Participants were n = 455 college students (79.6% female, 51% European Ancestry/EA, 24% African Ancestry/AFR, 25% Americas Ancestry/AMER) from a longitudinal study during the initial stage (March-May 2020) of the pandemic. Path models allowed for the examination of PRS and previously identified COVID-19 impact constructs. Results: There was a main effect of the AUD PRS on AUD symptoms within the EA group ([beta]: 0.165, p < 0.01). Additionally, food/housing insecurity was predictive in the AMER group ([beta]: 0.295, p < 0.05), and greater increases in substance use were associated with AUD symptoms for EA ([beta]: 0.459, p < 0.001) and AMER groups ([beta]: 0.468, p < 0.001). Conclusions: Greater food/housing instability and increases in substance use, as well higher scores on PRS are associated with more AUD symptoms for some ancestral groups within this college sample.
Abstractor: As Provided
Entry Date: 2025
Accession Number: EJ1473389
Database: ERIC
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Abstract:Objective: The purpose of this study was to test whether COVID impact interacts with genetic risk (polygenic risk score/PRS) to predict alcohol use disorder (AUD) symptoms. Method: Participants were n = 455 college students (79.6% female, 51% European Ancestry/EA, 24% African Ancestry/AFR, 25% Americas Ancestry/AMER) from a longitudinal study during the initial stage (March-May 2020) of the pandemic. Path models allowed for the examination of PRS and previously identified COVID-19 impact constructs. Results: There was a main effect of the AUD PRS on AUD symptoms within the EA group ([beta]: 0.165, p < 0.01). Additionally, food/housing insecurity was predictive in the AMER group ([beta]: 0.295, p < 0.05), and greater increases in substance use were associated with AUD symptoms for EA ([beta]: 0.459, p < 0.001) and AMER groups ([beta]: 0.468, p < 0.001). Conclusions: Greater food/housing instability and increases in substance use, as well higher scores on PRS are associated with more AUD symptoms for some ancestral groups within this college sample.
ISSN:0744-8481
1940-3208
DOI:10.1080/07448481.2024.2308255