Longitudinal Effects of Prenatal Alcohol Exposure on Visual Neurodevelopment over Infancy
Saved in:
| Title: | Longitudinal Effects of Prenatal Alcohol Exposure on Visual Neurodevelopment over Infancy |
|---|---|
| Language: | English |
| Authors: | Emma T. Margolis (ORCID |
| Source: | Developmental Psychology. 2024 60(9):1673-1698. |
| Availability: | American Psychological Association. Journals Department, 750 First Street NE, Washington, DC 20002. Tel: 800-374-2721; Tel: 202-336-5510; Fax: 202-336-5502; e-mail: order@apa.org; Web site: http://www.apa.org |
| Peer Reviewed: | Y |
| Page Count: | 26 |
| Publication Date: | 2024 |
| Document Type: | Journal Articles Reports - Research |
| Descriptors: | Prenatal Influences, Drinking, Alcohol Abuse, Pregnancy, Infants, Child Development, Neurology, Brain, Foreign Countries, Mothers, Individual Characteristics, Neurodevelopmental Disorders, Risk |
| Geographic Terms: | South Africa |
| DOI: | 10.1037/dev0001727 |
| ISSN: | 0012-1649 1939-0599 |
| Abstract: | Prenatal alcohol exposure (PAE) affects neurodevelopment in over 59 million individuals globally. Prior studies using dichotomous categorization of alcohol use and comorbid substance exposures provide limited knowledge of how prenatal alcohol specifically impacts early human neurodevelopment. In this longitudinal-cohort study from Cape Town, South Africa, PAE is measured continuously--characterizing timing, dose, and drinking patterns (i.e., binge drinking). High-density electroencephalography (EEG) during a visual-evoked potential (VEP) task was collected from infants aged 8 to 52 weeks with prenatal exposure exclusively to alcohol and matched on sociodemographic factors to infants with no substance exposure in utero. First trimester alcohol exposure related to altered timing of the P1 VEP component over the first 6 months postnatally, and first trimester binge drinking exposure altered timing of the P1 VEP components such that increased exposure was associated with longer VEP latencies while increasing age was related to shorter VEP latencies (n = 108). These results suggest alcohol exposure in the first trimester may alter visual neurodevelopmental timing in early infancy. Exploratory individual-difference analysis across infants with and without PAE tested the relation between VEP latencies and myelination for a subsample of infants with usable-magnetic resonance imaging (MRI) T1w and T2w scans collected at the same time point as EEG (n = 47). Decreased MRI T1w/T2w ratios (an indicator of myelin) in the primary visual cortex (n = 47) were linked to longer P1 VEP latencies. Results from these two sets of analyses suggest that prenatal alcohol and postnatal myelination may both separately impact VEP latency over infancy. |
| Abstractor: | As Provided |
| Entry Date: | 2026 |
| Accession Number: | EJ1499888 |
| Database: | ERIC |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: eric DbLabel: ERIC An: EJ1499888 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Longitudinal Effects of Prenatal Alcohol Exposure on Visual Neurodevelopment over Infancy – Name: Language Label: Language Group: Lang Data: English – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Emma+T%2E+Margolis%22">Emma T. Margolis</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0002-2036-8078">0000-0002-2036-8078</externalLink>)<br /><searchLink fieldCode="AR" term="%22Lauren+Davel%22">Lauren Davel</searchLink><br /><searchLink fieldCode="AR" term="%22Niall+J%2E+Bourke%22">Niall J. Bourke</searchLink><br /><searchLink fieldCode="AR" term="%22Cara+Bosco%22">Cara Bosco</searchLink><br /><searchLink fieldCode="AR" term="%22Michal+R%2E+Zieff%22">Michal R. Zieff</searchLink><br /><searchLink fieldCode="AR" term="%22Alexa+D%2E+Monachino%22">Alexa D. Monachino</searchLink><br /><searchLink fieldCode="AR" term="%22Thandeka+Mazubane%22">Thandeka Mazubane</searchLink><br /><searchLink fieldCode="AR" term="%22Simone+R%2E+Williams%22">Simone R. Williams</searchLink><br /><searchLink fieldCode="AR" term="%22Marlie+Miles%22">Marlie Miles</searchLink><br /><searchLink fieldCode="AR" term="%22Chloë+A%2E+Jacobs%22">Chloë A. Jacobs</searchLink><br /><searchLink fieldCode="AR" term="%22Sadeeka+Williams%22">Sadeeka Williams</searchLink><br /><searchLink fieldCode="AR" term="%22Layla+Bradford%22">Layla Bradford</searchLink><br /><searchLink fieldCode="AR" term="%22Candice+Knipe%22">Candice Knipe</searchLink><br /><searchLink fieldCode="AR" term="%22Zamazimba+Madi%22">Zamazimba Madi</searchLink><br /><searchLink fieldCode="AR" term="%22Bokang+Methola%22">Bokang Methola</searchLink><br /><searchLink fieldCode="AR" term="%22Tembeka+Mhlakwaphalwa%22">Tembeka Mhlakwaphalwa</searchLink><br /><searchLink fieldCode="AR" term="%22Nwabisa+Mlandu%22">Nwabisa Mlandu</searchLink><br /><searchLink fieldCode="AR" term="%22Khanyisa+Nkubungu%22">Khanyisa Nkubungu</searchLink><br /><searchLink fieldCode="AR" term="%22Zayaan+Goolam+Nabi%22">Zayaan Goolam Nabi</searchLink><br /><searchLink fieldCode="AR" term="%22Tracy+Pan%22">Tracy Pan</searchLink><br /><searchLink fieldCode="AR" term="%22Reese+Samuels%22">Reese Samuels</searchLink><br /><searchLink fieldCode="AR" term="%22Nicolò+Pini%22">Nicolò Pini</searchLink><br /><searchLink fieldCode="AR" term="%22Vanja+Klepac-Ceraj%22">Vanja Klepac-Ceraj</searchLink><br /><searchLink fieldCode="AR" term="%22William+P%2E+Fifer%22">William P. Fifer</searchLink><br /><searchLink fieldCode="AR" term="%22Daniel+C%2E+Alexander%22">Daniel C. Alexander</searchLink><br /><searchLink fieldCode="AR" term="%22Derek+K%2E+Jones%22">Derek K. Jones</searchLink><br /><searchLink fieldCode="AR" term="%22Steve+C%2E+R%2E+Williams%22">Steve C. R. Williams</searchLink><br /><searchLink fieldCode="AR" term="%22Dima+Amso%22">Dima Amso</searchLink><br /><searchLink fieldCode="AR" term="%22Kirsten+A%2E+Donald%22">Kirsten A. Donald</searchLink><br /><searchLink fieldCode="AR" term="%22Laurel+J%2E+Gabard-Durnam%22">Laurel J. Gabard-Durnam</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="SO" term="%22Developmental+Psychology%22"><i>Developmental Psychology</i></searchLink>. 2024 60(9):1673-1698. – Name: Avail Label: Availability Group: Avail Data: American Psychological Association. Journals Department, 750 First Street NE, Washington, DC 20002. Tel: 800-374-2721; Tel: 202-336-5510; Fax: 202-336-5502; e-mail: order@apa.org; Web site: http://www.apa.org – Name: PeerReviewed Label: Peer Reviewed Group: SrcInfo Data: Y – Name: Pages Label: Page Count Group: Src Data: 26 – Name: DatePubCY Label: Publication Date Group: Date Data: 2024 – Name: TypeDocument Label: Document Type Group: TypDoc Data: Journal Articles<br />Reports - Research – Name: Subject Label: Descriptors Group: Su Data: <searchLink fieldCode="DE" term="%22Prenatal+Influences%22">Prenatal Influences</searchLink><br /><searchLink fieldCode="DE" term="%22Drinking%22">Drinking</searchLink><br /><searchLink fieldCode="DE" term="%22Alcohol+Abuse%22">Alcohol Abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnancy%22">Pregnancy</searchLink><br /><searchLink fieldCode="DE" term="%22Infants%22">Infants</searchLink><br /><searchLink fieldCode="DE" term="%22Child+Development%22">Child Development</searchLink><br /><searchLink fieldCode="DE" term="%22Neurology%22">Neurology</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Foreign+Countries%22">Foreign Countries</searchLink><br /><searchLink fieldCode="DE" term="%22Mothers%22">Mothers</searchLink><br /><searchLink fieldCode="DE" term="%22Individual+Characteristics%22">Individual Characteristics</searchLink><br /><searchLink fieldCode="DE" term="%22Neurodevelopmental+Disorders%22">Neurodevelopmental Disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Risk%22">Risk</searchLink> – Name: Subject Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22South+Africa%22">South Africa</searchLink> – Name: DOI Label: DOI Group: ID Data: 10.1037/dev0001727 – Name: ISSN Label: ISSN Group: ISSN Data: 0012-1649<br />1939-0599 – Name: Abstract Label: Abstract Group: Ab Data: Prenatal alcohol exposure (PAE) affects neurodevelopment in over 59 million individuals globally. Prior studies using dichotomous categorization of alcohol use and comorbid substance exposures provide limited knowledge of how prenatal alcohol specifically impacts early human neurodevelopment. In this longitudinal-cohort study from Cape Town, South Africa, PAE is measured continuously--characterizing timing, dose, and drinking patterns (i.e., binge drinking). High-density electroencephalography (EEG) during a visual-evoked potential (VEP) task was collected from infants aged 8 to 52 weeks with prenatal exposure exclusively to alcohol and matched on sociodemographic factors to infants with no substance exposure in utero. First trimester alcohol exposure related to altered timing of the P1 VEP component over the first 6 months postnatally, and first trimester binge drinking exposure altered timing of the P1 VEP components such that increased exposure was associated with longer VEP latencies while increasing age was related to shorter VEP latencies (n = 108). These results suggest alcohol exposure in the first trimester may alter visual neurodevelopmental timing in early infancy. Exploratory individual-difference analysis across infants with and without PAE tested the relation between VEP latencies and myelination for a subsample of infants with usable-magnetic resonance imaging (MRI) T1w and T2w scans collected at the same time point as EEG (n = 47). Decreased MRI T1w/T2w ratios (an indicator of myelin) in the primary visual cortex (n = 47) were linked to longer P1 VEP latencies. Results from these two sets of analyses suggest that prenatal alcohol and postnatal myelination may both separately impact VEP latency over infancy. – Name: AbstractInfo Label: Abstractor Group: Ab Data: As Provided – Name: DateEntry Label: Entry Date Group: Date Data: 2026 – Name: AN Label: Accession Number Group: ID Data: EJ1499888 |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=eric&AN=EJ1499888 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1037/dev0001727 Languages: – Text: English PhysicalDescription: Pagination: PageCount: 26 StartPage: 1673 Subjects: – SubjectFull: Prenatal Influences Type: general – SubjectFull: Drinking Type: general – SubjectFull: Alcohol Abuse Type: general – SubjectFull: Pregnancy Type: general – SubjectFull: Infants Type: general – SubjectFull: Child Development Type: general – SubjectFull: Neurology Type: general – SubjectFull: Brain Type: general – SubjectFull: Foreign Countries Type: general – SubjectFull: Mothers Type: general – SubjectFull: Individual Characteristics Type: general – SubjectFull: Neurodevelopmental Disorders Type: general – SubjectFull: Risk Type: general – SubjectFull: South Africa Type: general Titles: – TitleFull: Longitudinal Effects of Prenatal Alcohol Exposure on Visual Neurodevelopment over Infancy Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Emma T. Margolis – PersonEntity: Name: NameFull: Lauren Davel – PersonEntity: Name: NameFull: Niall J. Bourke – PersonEntity: Name: NameFull: Cara Bosco – PersonEntity: Name: NameFull: Michal R. Zieff – PersonEntity: Name: NameFull: Alexa D. Monachino – PersonEntity: Name: NameFull: Thandeka Mazubane – PersonEntity: Name: NameFull: Simone R. Williams – PersonEntity: Name: NameFull: Marlie Miles – PersonEntity: Name: NameFull: Chloë A. Jacobs – PersonEntity: Name: NameFull: Sadeeka Williams – PersonEntity: Name: NameFull: Layla Bradford – PersonEntity: Name: NameFull: Candice Knipe – PersonEntity: Name: NameFull: Zamazimba Madi – PersonEntity: Name: NameFull: Bokang Methola – PersonEntity: Name: NameFull: Tembeka Mhlakwaphalwa – PersonEntity: Name: NameFull: Nwabisa Mlandu – PersonEntity: Name: NameFull: Khanyisa Nkubungu – PersonEntity: Name: NameFull: Zayaan Goolam Nabi – PersonEntity: Name: NameFull: Tracy Pan – PersonEntity: Name: NameFull: Reese Samuels – PersonEntity: Name: NameFull: Nicolò Pini – PersonEntity: Name: NameFull: Vanja Klepac-Ceraj – PersonEntity: Name: NameFull: William P. Fifer – PersonEntity: Name: NameFull: Daniel C. Alexander – PersonEntity: Name: NameFull: Derek K. Jones – PersonEntity: Name: NameFull: Steve C. R. Williams – PersonEntity: Name: NameFull: Dima Amso – PersonEntity: Name: NameFull: Kirsten A. Donald – PersonEntity: Name: NameFull: Laurel J. Gabard-Durnam IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 0012-1649 – Type: issn-electronic Value: 1939-0599 Numbering: – Type: volume Value: 60 – Type: issue Value: 9 Titles: – TitleFull: Developmental Psychology Type: main |
| ResultId | 1 |
