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Functional Voice Restoration after Laryngeal Transplantation: A Multidisciplinary Protocol and Longitudinal Outcomes

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Title: Functional Voice Restoration after Laryngeal Transplantation: A Multidisciplinary Protocol and Longitudinal Outcomes
Language: English
Authors: Bin Zeng, Hailing Gu (ORCID 0000-0002-1860-3841), Zheng Jiang (ORCID 0000-0001-7160-4512), Mailudan Ainiwaer, Yitao Zheng, Jimin Yang, Jia Ren, Fei Chen (ORCID 0000-0003-2152-368X)
Source: International Journal of Language & Communication Disorders. 2026 61(3).
Availability: Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us
Peer Reviewed: Y
Page Count: 9
Publication Date: 2026
Document Type: Journal Articles
Reports - Research
Descriptors: Human Body, Surgery, Voice Disorders, Speech Therapy, Rehabilitation Programs, Rehabilitation, Protocol Analysis, Neurological Organization, Individualized Instruction
DOI: 10.1111/1460-6984.70228
ISSN: 1368-2822
1460-6984
Abstract: Introduction: Laryngeal transplantation offers the potential for patients to regain vocal function, yet standardised voice rehabilitation protocols are lacking. We share the experience of our team in the regular follow-up of voice function evaluation and address this gap by establishing a multidisciplinary pathway for functional recovery. Methods: Four male transplant recipients (3 laryngeal cancers, 1 hypopharyngeal cancer) underwent protocolized assessments at 1/3/6/8 months post-op: subjective assessment (GRBAS scale) and objective evaluation (multiparametric acoustic analysis and electronic laryngoscopy). Personalized rehabilitation was delivered weekly by a licensed speech therapist. Protocol evolution occurred: Patients 1-2 received conventional training; Patients 3-4 received intensive neuromuscular reinnervation strategies. Results: The voice of the four patients showed a gradual decrease in the degree of hoarseness, a gradual alleviation of breathiness, and a gradual decrease in asthenia score, with the overall condition improving. The MPT was about 1.8 s at 1 month after surgery which kept increasing in all patients. The 3rd patient, who performed the best among the 4 patients, had an MPT of more than 10 s at 8 months after surgery. Laryngeal mucosa sensory function was gradually established in patients starting 3 months after operation, and compensatory vibration of ventricular band appeared at 8 months after operation with the assistance of voice training. Conclusions: This study anchored to neuromuscular reinnervation milestones demonstrates that standardised evaluations coupled with individualized training progressively restore vocal function. Our protocolized framework guides evidence-based rehabilitation for institutions pursuing laryngeal transplantation.
Abstractor: As Provided
Entry Date: 2026
Accession Number: EJ1506836
Database: ERIC
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  Data: Functional Voice Restoration after Laryngeal Transplantation: A Multidisciplinary Protocol and Longitudinal Outcomes
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  Data: <searchLink fieldCode="AR" term="%22Bin+Zeng%22">Bin Zeng</searchLink><br /><searchLink fieldCode="AR" term="%22Hailing+Gu%22">Hailing Gu</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0002-1860-3841">0000-0002-1860-3841</externalLink>)<br /><searchLink fieldCode="AR" term="%22Zheng+Jiang%22">Zheng Jiang</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0001-7160-4512">0000-0001-7160-4512</externalLink>)<br /><searchLink fieldCode="AR" term="%22Mailudan+Ainiwaer%22">Mailudan Ainiwaer</searchLink><br /><searchLink fieldCode="AR" term="%22Yitao+Zheng%22">Yitao Zheng</searchLink><br /><searchLink fieldCode="AR" term="%22Jimin+Yang%22">Jimin Yang</searchLink><br /><searchLink fieldCode="AR" term="%22Jia+Ren%22">Jia Ren</searchLink><br /><searchLink fieldCode="AR" term="%22Fei+Chen%22">Fei Chen</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0003-2152-368X">0000-0003-2152-368X</externalLink>)
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  Data: <searchLink fieldCode="SO" term="%22International+Journal+of+Language+%26+Communication+Disorders%22"><i>International Journal of Language & Communication Disorders</i></searchLink>. 2026 61(3).
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  Data: Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us
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  Data: 2026
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  Data: Journal Articles<br />Reports - Research
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  Data: <searchLink fieldCode="DE" term="%22Human+Body%22">Human Body</searchLink><br /><searchLink fieldCode="DE" term="%22Surgery%22">Surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Voice+Disorders%22">Voice Disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Speech+Therapy%22">Speech Therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Rehabilitation+Programs%22">Rehabilitation Programs</searchLink><br /><searchLink fieldCode="DE" term="%22Rehabilitation%22">Rehabilitation</searchLink><br /><searchLink fieldCode="DE" term="%22Protocol+Analysis%22">Protocol Analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Neurological+Organization%22">Neurological Organization</searchLink><br /><searchLink fieldCode="DE" term="%22Individualized+Instruction%22">Individualized Instruction</searchLink>
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  Data: 10.1111/1460-6984.70228
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  Data: 1368-2822<br />1460-6984
– Name: Abstract
  Label: Abstract
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  Data: Introduction: Laryngeal transplantation offers the potential for patients to regain vocal function, yet standardised voice rehabilitation protocols are lacking. We share the experience of our team in the regular follow-up of voice function evaluation and address this gap by establishing a multidisciplinary pathway for functional recovery. Methods: Four male transplant recipients (3 laryngeal cancers, 1 hypopharyngeal cancer) underwent protocolized assessments at 1/3/6/8 months post-op: subjective assessment (GRBAS scale) and objective evaluation (multiparametric acoustic analysis and electronic laryngoscopy). Personalized rehabilitation was delivered weekly by a licensed speech therapist. Protocol evolution occurred: Patients 1-2 received conventional training; Patients 3-4 received intensive neuromuscular reinnervation strategies. Results: The voice of the four patients showed a gradual decrease in the degree of hoarseness, a gradual alleviation of breathiness, and a gradual decrease in asthenia score, with the overall condition improving. The MPT was about 1.8 s at 1 month after surgery which kept increasing in all patients. The 3rd patient, who performed the best among the 4 patients, had an MPT of more than 10 s at 8 months after surgery. Laryngeal mucosa sensory function was gradually established in patients starting 3 months after operation, and compensatory vibration of ventricular band appeared at 8 months after operation with the assistance of voice training. Conclusions: This study anchored to neuromuscular reinnervation milestones demonstrates that standardised evaluations coupled with individualized training progressively restore vocal function. Our protocolized framework guides evidence-based rehabilitation for institutions pursuing laryngeal transplantation.
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      – SubjectFull: Surgery
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