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Citalopram Treatment of Pediatric Recurrent Abdominal Pain and Comorbid Internalizing Disorders: An Exploratory Study

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Title: Citalopram Treatment of Pediatric Recurrent Abdominal Pain and Comorbid Internalizing Disorders: An Exploratory Study
Language: English
Authors: Campo, John V., Perel, James, Lucas, Amanda, Bridge, Jeff, Ehmann, Mary, Kalas, Catherine, Monk, Kelly, Axelson, David, Birmaher, Boris, Ryan, Neal, Di Lorenzo, Carlo, Brent, David A.
Source: Journal of the American Academy of Child and Adolescent Psychiatry. -1242 Oct 2004 43(10):1234-1234.
Availability: Lippincott Williams & Wilkins, P.O. Box 1620, Hagerstown, MD 21741. Tel: 800-638-3030 (Toll Free); Fax: 301-223-2400.
Peer Reviewed: Y
Page Count: 9
Publication Date: 2004
Document Type: Journal Articles
Education Level: Elementary Secondary Education
Descriptors: Psychiatry, Pediatrics, Pain, Depression (Psychology), Anxiety, Drug Therapy, Chronic Illness, Children, Adolescents, Psychological Patterns
ISSN: 0890-8567
Abstract: Objective: To assess the potential efficacy, tolerability, and safety of citalopram in the treatment of functional pediatric recurrent abdominal pain and comorbid internalizing disorders. Method: Twenty-five clinically referred children and adolescents with recurrent abdominal pain aged 7 to 18 years, inclusive, participated in a 12-week, flexible-dose, open-label trial of citalopram. Primary outcome measure was the Clinical Global Impression Scale-Improvement, with responders defined by ratings of 1 (very much improved) or 2 (much improved). Secondary measures included self- and parent reports of abdominal pain, anxiety, depression, other somatic symptoms, and functional impairment. Side effects were assessed using a standardized checklist. Data were analyzed using an intent-to-treat format and the last observation carried forward procedure. Results: Twenty-one subjects (84%) were classified as responders (Clinical Global Impression Scale-Improvement score [less than or equal to]2). Citalopram was generally well tolerated. Four subjects withdrew prematurely, one due to reported visual side effects. Ratings of abdominal pain, anxiety, depression, other somatic symptoms, and functional impairment all improved significantly over the course of the study compared with baseline. Conclusions: Citalopram is a promising treatment for functional pediatric recurrent abdominal pain and deserves additional study with a randomized, placebo-controlled clinical trial. J. Am. Acad. Child Adolesc. Psychiatry, 2004;43(10):1234-1242. Key Words: abdominal pain, anxiety, depression, comorbidity, serotonin.
Abstractor: Author
Entry Date: 2005
Accession Number: EJ696589
Database: ERIC
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  Data: Objective: To assess the potential efficacy, tolerability, and safety of citalopram in the treatment of functional pediatric recurrent abdominal pain and comorbid internalizing disorders. Method: Twenty-five clinically referred children and adolescents with recurrent abdominal pain aged 7 to 18 years, inclusive, participated in a 12-week, flexible-dose, open-label trial of citalopram. Primary outcome measure was the Clinical Global Impression Scale-Improvement, with responders defined by ratings of 1 (very much improved) or 2 (much improved). Secondary measures included self- and parent reports of abdominal pain, anxiety, depression, other somatic symptoms, and functional impairment. Side effects were assessed using a standardized checklist. Data were analyzed using an intent-to-treat format and the last observation carried forward procedure. Results: Twenty-one subjects (84%) were classified as responders (Clinical Global Impression Scale-Improvement score [less than or equal to]2). Citalopram was generally well tolerated. Four subjects withdrew prematurely, one due to reported visual side effects. Ratings of abdominal pain, anxiety, depression, other somatic symptoms, and functional impairment all improved significantly over the course of the study compared with baseline. Conclusions: Citalopram is a promising treatment for functional pediatric recurrent abdominal pain and deserves additional study with a randomized, placebo-controlled clinical trial. J. Am. Acad. Child Adolesc. Psychiatry, 2004;43(10):1234-1242. Key Words: abdominal pain, anxiety, depression, comorbidity, serotonin.
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      – SubjectFull: Pain
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