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Back to Africa: Tracing Dyslexia Genes in East Africa

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Title: Back to Africa: Tracing Dyslexia Genes in East Africa
Language: English
Authors: Grigorenko, Elena L., Naples, Adam, Chang, Joseph, Romano, Christina, Ngorosho, Damaris, Kungulilo, Selemani, Jukes, Matthew, Bundy, Donald
Source: Reading and Writing: An Interdisciplinary Journal. Feb 2007 20(1-2):27-49.
Availability: Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com
Peer Reviewed: Y
Page Count: 23
Publication Date: 2007
Document Type: Journal Articles
Reports - Descriptive
Descriptors: Foreign Countries, African Languages, Siblings, Rural Areas, Reading Difficulties, Genetics, Reading Tests, Reading Research
Geographic Terms: Africa, Tanzania
DOI: 10.1007/s11145-006-9017-y
ISSN: 0922-4777
Abstract: A sample of Swahili-speaking probands with reading difficulties was identified from a large representative sample of 1,500 school children in the rural areas of Tanzania. Families of these probands (n = 88) were invited to participate in the study. The proband and his/her siblings received a battery of reading-related tasks and performance on these tasks was recorded and treated as phenotypic data. Molecular-genetic analyses were carried out with 47 highly polymorphic markers spanning three previously identified regions of interest harboring susceptibility loci for reading difficulties: 2p, 6p, and 15q (DYX1-DYX3). The analyses revealed the involvement of these regions in the development of reading difficulties in Swahili. The linkage signals are especially pronounced for time (compared with error) indicators of reading difficulties. These findings are easily interpretable because in transparent languages such as Swahili deficits in reading are more related to the rate/speed of reading and reading-related processes than to the number of errors made. In short, the study incrementally advances the field by adding an understudied language and an understudied population to the variety of languages and populations in the field of molecular-genetic studies of reading difficulties.
Abstractor: Author
Entry Date: 2007
Accession Number: EJ757947
Database: ERIC
FullText Links:
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  Data: Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com
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  Data: 10.1007/s11145-006-9017-y
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  Data: A sample of Swahili-speaking probands with reading difficulties was identified from a large representative sample of 1,500 school children in the rural areas of Tanzania. Families of these probands (n = 88) were invited to participate in the study. The proband and his/her siblings received a battery of reading-related tasks and performance on these tasks was recorded and treated as phenotypic data. Molecular-genetic analyses were carried out with 47 highly polymorphic markers spanning three previously identified regions of interest harboring susceptibility loci for reading difficulties: 2p, 6p, and 15q (DYX1-DYX3). The analyses revealed the involvement of these regions in the development of reading difficulties in Swahili. The linkage signals are especially pronounced for time (compared with error) indicators of reading difficulties. These findings are easily interpretable because in transparent languages such as Swahili deficits in reading are more related to the rate/speed of reading and reading-related processes than to the number of errors made. In short, the study incrementally advances the field by adding an understudied language and an understudied population to the variety of languages and populations in the field of molecular-genetic studies of reading difficulties.
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        Type: general
      – SubjectFull: African Languages
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      – SubjectFull: Siblings
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      – SubjectFull: Rural Areas
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      – SubjectFull: Reading Difficulties
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