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Septohippocampal Acetylcholine: Involved in but Not Necessary for Learning and Memory?

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Title: Septohippocampal Acetylcholine: Involved in but Not Necessary for Learning and Memory?
Language: English
Authors: Parent, Marise B., Baxter, Mark G.
Source: Learning & Memory. Jan 2004 11(1):9-20.
Availability: Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Peer Reviewed: Y
Physical Description: PDF
Page Count: 12
Publication Date: 2004
Document Type: Information Analyses
Journal Articles
Descriptors: Memory, Learning, Biochemistry, Neurology, Brain, Neurological Organization, Correlation
ISSN: 1072-0502
Abstract: The neurotransmitter acetylcholine (ACh) has been accorded an important role in supporting learning and memory processes in the hippocampus. Cholinergic activity in the hippocampus is correlated with memory, and restoration of ACh in the hippocampus after disruption of the septohippocampal pathway is sufficient to rescue memory. However, selective ablation of cholinergic septohippocampal projections is largely without effect on hippocampal-dependent learning and memory processes. We consider the evidence underlying each of these statements, and the contradictions they pose for understanding the functional role of hippocampal ACh in memory. We suggest that although hippocampal ACh is involved in memory in the intact brain, it is not necessary for many aspects of hippocampal memory function.
Abstractor: Author
Number of References: 244
Entry Date: 2007
Access URL: https://www.learnmem.org/cgi/content/abstract/11/1/9
Accession Number: EJ767779
Database: ERIC
FullText Text:
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  Data: Septohippocampal Acetylcholine: Involved in but Not Necessary for Learning and Memory?
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  Data: Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
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  Data: The neurotransmitter acetylcholine (ACh) has been accorded an important role in supporting learning and memory processes in the hippocampus. Cholinergic activity in the hippocampus is correlated with memory, and restoration of ACh in the hippocampus after disruption of the septohippocampal pathway is sufficient to rescue memory. However, selective ablation of cholinergic septohippocampal projections is largely without effect on hippocampal-dependent learning and memory processes. We consider the evidence underlying each of these statements, and the contradictions they pose for understanding the functional role of hippocampal ACh in memory. We suggest that although hippocampal ACh is involved in memory in the intact brain, it is not necessary for many aspects of hippocampal memory function.
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