Vergence Deficits in Patients with Cerebellar Lesions
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| Title: | Vergence Deficits in Patients with Cerebellar Lesions |
|---|---|
| Language: | English |
| Authors: | Sander, T., Sprenger, A., Neumann, G. |
| Source: | Brain. Jan 2009 132(1):103-115. |
| Availability: | Oxford University Press. Great Clarendon Street, Oxford, OX2 6DP, UK. Tel: +44-1865-353907; Fax: +44-1865-353485; e-mail: jnls.cust.serv@oxfordjournals.org; Web site: http://brain.oxfordjournals.org/ |
| Peer Reviewed: | Y |
| Physical Description: | |
| Page Count: | 13 |
| Publication Date: | 2009 |
| Document Type: | Journal Articles Reports - Research |
| Descriptors: | Animals, Eye Movements, Patients, Human Body, Brain, Neurological Impairments, Control Groups, Cognitive Processes |
| DOI: | 10.1093/brain/awn306 |
| ISSN: | 0006-8950 |
| Abstract: | The cerebellum is part of the cortico-ponto-cerebellar circuit for conjugate eye movements. Recent animal data suggest an additional role of the cerebellum for the control of binocular alignment and disconjugate, i.e. vergence eye movements. The latter is separated into two different components: fast vergence (to step targets) and slow vergence (to ramp and sinusoidal targets). The aim of this study was to investigate whether circumscribed cerebellar lesions affect these dynamic vergence eye movements. Disconjugate fast and slow vergence, conjugate smooth pursuit and saccades were binocularly recorded by a scleral search coil system in 20 patients with acute cerebellar lesions (all ischemic strokes except for one) and 20 age-matched healthy controls. Patients showed impairment of slow vergence while fast vergence was unaffected. Slow vergence gain to sinusoidal targets was significantly reduced, both in convergence and divergence direction. Divergence but not convergence velocity to ramp targets was reduced. Conjugate smooth pursuit eye movements to sinusoidal and to step-ramp targets were impaired. Patients had saccadic hypometria. All defects were particularly expressed in patients with vermis lesions. In contrast to recent animal data fast vergence was not impaired in any of our patient subgroups. We conclude that (i) the human cerebellum, in particular the vermis, is involved in the processing of dynamic vergence eye movements and (ii) cerebellar lesions elicit dissociable effects on fast and slow vergence. |
| Abstractor: | As Provided |
| Entry Date: | 2009 |
| Accession Number: | EJ839795 |
| Database: | ERIC |
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| Items | – Name: Title Label: Title Group: Ti Data: Vergence Deficits in Patients with Cerebellar Lesions – Name: Language Label: Language Group: Lang Data: English – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sander%2C+T%2E%22">Sander, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Sprenger%2C+A%2E%22">Sprenger, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Neumann%2C+G%2E%22">Neumann, G.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="SO" term="%22Brain%22"><i>Brain</i></searchLink>. Jan 2009 132(1):103-115. – Name: Avail Label: Availability Group: Avail Data: Oxford University Press. Great Clarendon Street, Oxford, OX2 6DP, UK. Tel: +44-1865-353907; Fax: +44-1865-353485; e-mail: jnls.cust.serv@oxfordjournals.org; Web site: http://brain.oxfordjournals.org/ – Name: PeerReviewed Label: Peer Reviewed Group: SrcInfo Data: Y – Name: PhysDesc Label: Physical Description Group: PhysDesc Data: PDF – Name: Pages Label: Page Count Group: Src Data: 13 – Name: DatePubCY Label: Publication Date Group: Date Data: 2009 – Name: TypeDocument Label: Document Type Group: TypDoc Data: Journal Articles<br />Reports - Research – Name: Subject Label: Descriptors Group: Su Data: <searchLink fieldCode="DE" term="%22Animals%22">Animals</searchLink><br /><searchLink fieldCode="DE" term="%22Eye+Movements%22">Eye Movements</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink><br /><searchLink fieldCode="DE" term="%22Human+Body%22">Human Body</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Neurological+Impairments%22">Neurological Impairments</searchLink><br /><searchLink fieldCode="DE" term="%22Control+Groups%22">Control Groups</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+Processes%22">Cognitive Processes</searchLink> – Name: DOI Label: DOI Group: ID Data: 10.1093/brain/awn306 – Name: ISSN Label: ISSN Group: ISSN Data: 0006-8950 – Name: Abstract Label: Abstract Group: Ab Data: The cerebellum is part of the cortico-ponto-cerebellar circuit for conjugate eye movements. Recent animal data suggest an additional role of the cerebellum for the control of binocular alignment and disconjugate, i.e. vergence eye movements. The latter is separated into two different components: fast vergence (to step targets) and slow vergence (to ramp and sinusoidal targets). The aim of this study was to investigate whether circumscribed cerebellar lesions affect these dynamic vergence eye movements. Disconjugate fast and slow vergence, conjugate smooth pursuit and saccades were binocularly recorded by a scleral search coil system in 20 patients with acute cerebellar lesions (all ischemic strokes except for one) and 20 age-matched healthy controls. Patients showed impairment of slow vergence while fast vergence was unaffected. Slow vergence gain to sinusoidal targets was significantly reduced, both in convergence and divergence direction. Divergence but not convergence velocity to ramp targets was reduced. Conjugate smooth pursuit eye movements to sinusoidal and to step-ramp targets were impaired. Patients had saccadic hypometria. All defects were particularly expressed in patients with vermis lesions. In contrast to recent animal data fast vergence was not impaired in any of our patient subgroups. We conclude that (i) the human cerebellum, in particular the vermis, is involved in the processing of dynamic vergence eye movements and (ii) cerebellar lesions elicit dissociable effects on fast and slow vergence. – Name: AbstractInfo Label: Abstractor Group: Ab Data: As Provided – Name: DateEntry Label: Entry Date Group: Date Data: 2009 – Name: AN Label: Accession Number Group: ID Data: EJ839795 |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=eric&AN=EJ839795 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1093/brain/awn306 Languages: – Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 103 Subjects: – SubjectFull: Animals Type: general – SubjectFull: Eye Movements Type: general – SubjectFull: Patients Type: general – SubjectFull: Human Body Type: general – SubjectFull: Brain Type: general – SubjectFull: Neurological Impairments Type: general – SubjectFull: Control Groups Type: general – SubjectFull: Cognitive Processes Type: general Titles: – TitleFull: Vergence Deficits in Patients with Cerebellar Lesions Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sander, T. – PersonEntity: Name: NameFull: Sprenger, A. – PersonEntity: Name: NameFull: Neumann, G. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 0006-8950 Numbering: – Type: volume Value: 132 – Type: issue Value: 1 Titles: – TitleFull: Brain Type: main |
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