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Role of Dentate Gyrus in Aligning Internal Spatial Map to External Landmark

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Title: Role of Dentate Gyrus in Aligning Internal Spatial Map to External Landmark
Language: English
Authors: Lee, Jong Won, Kim, Woon Ryoung, Sun, Woong
Source: Learning & Memory. Sep 2009 16(9):530-536.
Availability: Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Peer Reviewed: Y
Physical Description: PDF
Page Count: 7
Publication Date: 2009
Document Type: Journal Articles
Reports - Research
Descriptors: Animals, Memory, Spatial Ability, Brain Hemisphere Functions, Role, Physiology, Cytology, Cues, Task Analysis, Prediction, Visual Stimuli, Cognitive Mapping, Sensory Integration
DOI: 10.1101/lm.1483709
ISSN: 1072-0502
Abstract: Humans and animals form internal representations of external space based on their own body movement (dead reckoning) as well as external landmarks. It is poorly understood, however, how different types of information are integrated to form a unified representation of external space. To examine the role of dentate gyrus (DG) in this process, we conducted physiological and behavioral experiments using Bax knockout (Bax-KO) mice in which newly generated granule cells continue to accumulate disrupting neural circuitry specifically in the DG. Unlike in wild-type (WT) littermates, spatial firing of hippocampal neurons was completely dissociated from a distinct visual cue and instead, tended to stay constant relative to the recording room in Bax-KO mice. Behaviorally, whereas spatial learning was intact in conventional spatial reference memory tasks, Bax-KO mice were impaired in finding a target location based on visual landmarks when target locations predicted by dead reckoning and visual landmarks were made incongruent. These results provide converging evidence for the role of DG in binding animal's internal spatial map with the sensory information on external landmarks in building a distinct spatial representation for each environment.
Abstractor: As Provided
Entry Date: 2009
Accession Number: EJ855935
Database: ERIC
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  Data: Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
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  Data: Humans and animals form internal representations of external space based on their own body movement (dead reckoning) as well as external landmarks. It is poorly understood, however, how different types of information are integrated to form a unified representation of external space. To examine the role of dentate gyrus (DG) in this process, we conducted physiological and behavioral experiments using Bax knockout (Bax-KO) mice in which newly generated granule cells continue to accumulate disrupting neural circuitry specifically in the DG. Unlike in wild-type (WT) littermates, spatial firing of hippocampal neurons was completely dissociated from a distinct visual cue and instead, tended to stay constant relative to the recording room in Bax-KO mice. Behaviorally, whereas spatial learning was intact in conventional spatial reference memory tasks, Bax-KO mice were impaired in finding a target location based on visual landmarks when target locations predicted by dead reckoning and visual landmarks were made incongruent. These results provide converging evidence for the role of DG in binding animal's internal spatial map with the sensory information on external landmarks in building a distinct spatial representation for each environment.
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      – TitleFull: Role of Dentate Gyrus in Aligning Internal Spatial Map to External Landmark
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