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Baseline Cognition, Behavior, and Motor Skills in Children with New-Onset, Idiopathic Epilepsy

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Title: Baseline Cognition, Behavior, and Motor Skills in Children with New-Onset, Idiopathic Epilepsy
Language: English
Authors: Bhise, Vikram V., Burack, Gail D., Mandelbaum, David E.
Source: Developmental Medicine & Child Neurology. Jan 2010 52(1):22-26.
Availability: Wiley-Blackwell. 350 Main Street, Malden, MA 02148. Tel: 800-835-6770; Tel: 781-388-8598; Fax: 781-388-8232; e-mail: cs-journals@wiley.com; Web site: http://www.wiley.com/WileyCDA/
Peer Reviewed: Y
Physical Description: PDF
Page Count: 5
Publication Date: 2010
Document Type: Journal Articles
Reports - Research
Descriptors: Epilepsy, Seizures, Memory, Cognitive Development, Psychomotor Skills, Child Behavior, Genetics, Measures (Individuals), Intelligence Quotient, Scores, Classification, Attention, Vocabulary, Auditory Stimuli, Learning Processes, Visual Stimuli, Cognitive Processes
DOI: 10.1111/j.1469-8749.2009.03404.x
ISSN: 0012-1622
Abstract: Aim: Epilepsy is associated with difficulties in cognition and behavior in children. These problems have been attributed to genetics, ongoing seizures, psychosocial issues, underlying abnormality of the brain, and/or antiepileptic drugs. In a previous study, we found baseline cognitive differences between children with partial versus generalized and convulsive versus non-convulsive seizures. Measures in that study focused primarily on IQ scores. In the present study, we assessed baseline function with respect to new learning, attention, and memory, thus providing a more comprehensive profile than our previous study. Method: We examined 57 children (42 females, 15 males), aged 6 to 17 years (mean 10y 1mo, SD 2y 9mo), with new-onset, idiopathic epilepsy, using tests of cognitive function reflective of new learning, memory, and attention. Seizures were classified as generalized convulsive (n=5), generalized non-convulsive (n=18), or focal (n=34). Focal seizures were divided into unilateral versus bilateral independent foci, and presence versus absence of secondary generalization. Results: Attention was a particular area of weakness across all groups. The Vocabulary score of an intelligence screen was higher for the focal seizure groups (p=0.012), primarily because of a difference between the unilateral focal and the primary generalized groups (p less than 0.047). Children with generalized, non-convulsive seizures performed significantly worse than the focal group on a measure of short-term auditory memory (p=0.019). All groups performed poorly on a test of visual-motor speed. Interpretation: These findings suggest intrinsic abnormalities in children with new-onset, idiopathic epilepsy at baseline.
Abstractor: As Provided
Entry Date: 2010
Accession Number: EJ872185
Database: ERIC
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  Data: Baseline Cognition, Behavior, and Motor Skills in Children with New-Onset, Idiopathic Epilepsy
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  Data: <searchLink fieldCode="SO" term="%22Developmental+Medicine+%26+Child+Neurology%22"><i>Developmental Medicine & Child Neurology</i></searchLink>. Jan 2010 52(1):22-26.
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  Data: Wiley-Blackwell. 350 Main Street, Malden, MA 02148. Tel: 800-835-6770; Tel: 781-388-8598; Fax: 781-388-8232; e-mail: cs-journals@wiley.com; Web site: http://www.wiley.com/WileyCDA/
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  Data: 10.1111/j.1469-8749.2009.03404.x
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  Data: 0012-1622
– Name: Abstract
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  Data: Aim: Epilepsy is associated with difficulties in cognition and behavior in children. These problems have been attributed to genetics, ongoing seizures, psychosocial issues, underlying abnormality of the brain, and/or antiepileptic drugs. In a previous study, we found baseline cognitive differences between children with partial versus generalized and convulsive versus non-convulsive seizures. Measures in that study focused primarily on IQ scores. In the present study, we assessed baseline function with respect to new learning, attention, and memory, thus providing a more comprehensive profile than our previous study. Method: We examined 57 children (42 females, 15 males), aged 6 to 17 years (mean 10y 1mo, SD 2y 9mo), with new-onset, idiopathic epilepsy, using tests of cognitive function reflective of new learning, memory, and attention. Seizures were classified as generalized convulsive (n=5), generalized non-convulsive (n=18), or focal (n=34). Focal seizures were divided into unilateral versus bilateral independent foci, and presence versus absence of secondary generalization. Results: Attention was a particular area of weakness across all groups. The Vocabulary score of an intelligence screen was higher for the focal seizure groups (p=0.012), primarily because of a difference between the unilateral focal and the primary generalized groups (p less than 0.047). Children with generalized, non-convulsive seizures performed significantly worse than the focal group on a measure of short-term auditory memory (p=0.019). All groups performed poorly on a test of visual-motor speed. Interpretation: These findings suggest intrinsic abnormalities in children with new-onset, idiopathic epilepsy at baseline.
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