View in EDS

Response Inhibition Is Associated with White Matter Microstructure in Children

Saved in:
Bibliographic Details
Title: Response Inhibition Is Associated with White Matter Microstructure in Children
Language: English
Authors: Madsen, Kathrine Skak, Baare, William F. C., Vestergaard, Martin
Source: Neuropsychologia. Mar 2010 48(4):854-862.
Availability: Elsevier. 6277 Sea Harbor Drive, Orlando, FL 32887-4800. Tel: 877-839-7126; Tel: 407-345-4020; Fax: 407-363-1354; e-mail: usjcs@elsevier.com; Web site: http://www.elsevier.com
Peer Reviewed: Y
Physical Description: PDF
Page Count: 9
Publication Date: 2010
Document Type: Journal Articles
Reports - Research
Descriptors: Responses, Inhibition, Children, Brain, Cognitive Processes, Neurological Organization, Cognitive Development
DOI: 10.1016/j.neuropsychologia.2009.11.001
ISSN: 0028-3932
Abstract: Cognitive control of thoughts, actions and emotions is important for normal behaviour and the development of such control continues throughout childhood and adolescence. Several lines of evidence suggest that response inhibition is primarily mediated by a right-lateralized network involving inferior frontal gyrus (IFG), presupplementary motor cortex (preSMA), and subthalamic nucleus. Though the brain's fibre tracts are known to develop during childhood, little is known about how fibre tract development within this network relates to developing behavioural control. Here we examined the relationship between response inhibition, as measured with the stop-signal task, and indices of regional white matter microstructure in typically-developing children. We hypothesized that better response inhibition performance would be associated with higher fractional anisotropy (FA) in fibre tracts within right IFG and preSMA after controlling for age. Mean FA and diffusivity values were extracted from right and left IFG and preSMA. As hypothesized, faster response inhibition was significantly associated with higher FA and lower perpendicular diffusivity in both the right IFG and the right preSMA, possibly reflecting faster speed of neural conduction within more densely packed or better myelinated fibre tracts. Moreover, both of these effects remained significant after controlling for age and whole brain estimates of these DTI parameters. Interestingly, right IFG and preSMA FA contributed additively to the prediction of performance variability. Observed associations may be related to variation in phase of maturation, to activity-dependent alterations in the network subserving response inhibition, or to stable individual differences in underlying neural system connectivity. (Contains 5 tables and 6 figures.)
Abstractor: As Provided
Entry Date: 2010
Accession Number: EJ877574
Database: ERIC
FullText Text:
  Availability: 0
Header DbId: eric
DbLabel: ERIC
An: EJ877574
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Response Inhibition Is Associated with White Matter Microstructure in Children
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Madsen%2C+Kathrine+Skak%22">Madsen, Kathrine Skak</searchLink><br /><searchLink fieldCode="AR" term="%22Baare%2C+William+F%2E+C%2E%22">Baare, William F. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Vestergaard%2C+Martin%22">Vestergaard, Martin</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="SO" term="%22Neuropsychologia%22"><i>Neuropsychologia</i></searchLink>. Mar 2010 48(4):854-862.
– Name: Avail
  Label: Availability
  Group: Avail
  Data: Elsevier. 6277 Sea Harbor Drive, Orlando, FL 32887-4800. Tel: 877-839-7126; Tel: 407-345-4020; Fax: 407-363-1354; e-mail: usjcs@elsevier.com; Web site: http://www.elsevier.com
– Name: PeerReviewed
  Label: Peer Reviewed
  Group: SrcInfo
  Data: Y
– Name: PhysDesc
  Label: Physical Description
  Group: PhysDesc
  Data: PDF
– Name: Pages
  Label: Page Count
  Group: Src
  Data: 9
– Name: DatePubCY
  Label: Publication Date
  Group: Date
  Data: 2010
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: Journal Articles<br />Reports - Research
– Name: Subject
  Label: Descriptors
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Responses%22">Responses</searchLink><br /><searchLink fieldCode="DE" term="%22Inhibition%22">Inhibition</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+Processes%22">Cognitive Processes</searchLink><br /><searchLink fieldCode="DE" term="%22Neurological+Organization%22">Neurological Organization</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+Development%22">Cognitive Development</searchLink>
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1016/j.neuropsychologia.2009.11.001
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 0028-3932
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Cognitive control of thoughts, actions and emotions is important for normal behaviour and the development of such control continues throughout childhood and adolescence. Several lines of evidence suggest that response inhibition is primarily mediated by a right-lateralized network involving inferior frontal gyrus (IFG), presupplementary motor cortex (preSMA), and subthalamic nucleus. Though the brain's fibre tracts are known to develop during childhood, little is known about how fibre tract development within this network relates to developing behavioural control. Here we examined the relationship between response inhibition, as measured with the stop-signal task, and indices of regional white matter microstructure in typically-developing children. We hypothesized that better response inhibition performance would be associated with higher fractional anisotropy (FA) in fibre tracts within right IFG and preSMA after controlling for age. Mean FA and diffusivity values were extracted from right and left IFG and preSMA. As hypothesized, faster response inhibition was significantly associated with higher FA and lower perpendicular diffusivity in both the right IFG and the right preSMA, possibly reflecting faster speed of neural conduction within more densely packed or better myelinated fibre tracts. Moreover, both of these effects remained significant after controlling for age and whole brain estimates of these DTI parameters. Interestingly, right IFG and preSMA FA contributed additively to the prediction of performance variability. Observed associations may be related to variation in phase of maturation, to activity-dependent alterations in the network subserving response inhibition, or to stable individual differences in underlying neural system connectivity. (Contains 5 tables and 6 figures.)
– Name: AbstractInfo
  Label: Abstractor
  Group: Ab
  Data: As Provided
– Name: DateEntry
  Label: Entry Date
  Group: Date
  Data: 2010
– Name: AN
  Label: Accession Number
  Group: ID
  Data: EJ877574
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=eric&AN=EJ877574
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.neuropsychologia.2009.11.001
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 854
    Subjects:
      – SubjectFull: Responses
        Type: general
      – SubjectFull: Inhibition
        Type: general
      – SubjectFull: Children
        Type: general
      – SubjectFull: Brain
        Type: general
      – SubjectFull: Cognitive Processes
        Type: general
      – SubjectFull: Neurological Organization
        Type: general
      – SubjectFull: Cognitive Development
        Type: general
    Titles:
      – TitleFull: Response Inhibition Is Associated with White Matter Microstructure in Children
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Madsen, Kathrine Skak
      – PersonEntity:
          Name:
            NameFull: Baare, William F. C.
      – PersonEntity:
          Name:
            NameFull: Vestergaard, Martin
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Type: published
              Y: 2010
          Identifiers:
            – Type: issn-print
              Value: 0028-3932
          Numbering:
            – Type: volume
              Value: 48
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Neuropsychologia
              Type: main
ResultId 1