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Mild Intellectual Disability Associated with a Progeny of Father-Daughter Incest: Genetic and Environmental Considerations

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Bibliographic Details
Title: Mild Intellectual Disability Associated with a Progeny of Father-Daughter Incest: Genetic and Environmental Considerations
Language: English
Authors: Ansermet, Francois, Lespinasse, James, Gimelli, Stefania
Source: Journal of Child Sexual Abuse. 2010 19(3):337-344.
Availability: Routledge. Available from: Taylor & Francis, Ltd. 325 Chestnut Street Suite 800, Philadelphia, PA 19106. Tel: 800-354-1420; Fax: 215-625-2940; Web site: http://www.tandf.co.uk/journals
Peer Reviewed: Y
Physical Description: PDF
Page Count: 8
Publication Date: 2010
Document Type: Journal Articles
Reports - Research
Descriptors: Sexual Abuse, Daughters, Mild Mental Retardation, Genetics, Fathers, Environmental Influences, Case Studies, Adults, Family Environment, Etiology
DOI: 10.1080/10538711003788991
ISSN: 1053-8712
Abstract: We report the case of a 34-year-old female resulting from a father-daughter sexual abuse and presenting a phenotype of mild intellectual disability with minor dysmorphic features. Karyotyping showed a normal 46, XX constitution. Array-based comparative genomic hybridization (array-CGH) revealed a heterozygote 320kb 6p22.3 microdeletion in the proband, encompassing only one known gene, and therefore unlikely to be the cause of the phenotype. However, the role of other genetic factors, such as a recessive condition, could not be ruled out as a putative cause for the phenotype. On the other hand, the role played by a heavily detrimental familial situation on the development and outcome, and possibly leading or contributing to a mild intellectual disability, should be taken into account. (Contains 1 figure.)
Abstractor: As Provided
Number of References: 17
Entry Date: 2010
Accession Number: EJ885021
Database: ERIC
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Abstract:We report the case of a 34-year-old female resulting from a father-daughter sexual abuse and presenting a phenotype of mild intellectual disability with minor dysmorphic features. Karyotyping showed a normal 46, XX constitution. Array-based comparative genomic hybridization (array-CGH) revealed a heterozygote 320kb 6p22.3 microdeletion in the proband, encompassing only one known gene, and therefore unlikely to be the cause of the phenotype. However, the role of other genetic factors, such as a recessive condition, could not be ruled out as a putative cause for the phenotype. On the other hand, the role played by a heavily detrimental familial situation on the development and outcome, and possibly leading or contributing to a mild intellectual disability, should be taken into account. (Contains 1 figure.)
ISSN:1053-8712
DOI:10.1080/10538711003788991