Associative, Bidirectional Changes in Neural Signaling Utilizing NMDA Receptor- and Endocannabinoid-Dependent Mechanisms
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| Title: | Associative, Bidirectional Changes in Neural Signaling Utilizing NMDA Receptor- and Endocannabinoid-Dependent Mechanisms |
|---|---|
| Language: | English |
| Authors: | Li, Qin, Burrell, Brian D. |
| Source: | Learning & Memory. Sep 2011 18(9):545-553. |
| Availability: | Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/ |
| Peer Reviewed: | Y |
| Physical Description: | |
| Page Count: | 9 |
| Publication Date: | 2011 |
| Document Type: | Journal Articles Reports - Research |
| Descriptors: | Intervals, Neurological Organization, Brain Hemisphere Functions, Animals, Cytology, Physiology, Neurology |
| DOI: | 10.1101/lm.2252511 |
| ISSN: | 1072-0502 |
| Abstract: | Persistent, bidirectional changes in synaptic signaling (that is, potentiation and depression of the synapse) can be induced by the precise timing of individual pre- and postsynaptic action potentials. However, far less attention has been paid to the ability of paired trains of action potentials to elicit persistent potentiation or depression. We examined plasticity following the pairing of spike trains in the touch mechanosensory neuron (T cell) and S interneuron (S cell) in the medicinal leech. Long-term potentiation (LTP) of T to S signaling was elicited when the T-cell spike train preceded the S-cell train. An interval 0 to +1 sec between the T- and S-cell spike trains was required to elicit long-term potentiation (LTP), and this potentiation was NMDA receptor (NMDAR)-dependent. Long-term depression (LTD) was elicited when S-cell activity preceded T-cell activity and the interval between the two spike trains was -0.2 sec to -10 sec. This surprisingly broad temporal window involved two distinct cellular mechanisms; an NMDAR-mediated LTD (NMDAR-LTD) when the pairing interval was relatively brief (less than -1 sec) and an endocannabinoid-mediated LTD (eCB-LTD) when longer pairing intervals were used (-1 to -10 sec). This eCB-LTD also required activation of a presynaptic transient receptor potential vanilloid (TRPV)-like receptor, presynaptic Ca[subscript 2+] release from intracellular stores and activation of voltage-gated Ca[subscript 2+] channels (VGCCs). These findings demonstrate that the pairing of spike trains elicits timing-dependent forms of LTP and LTD that are supported by a complex set of cellular mechanisms involving NMDARs and endocannabinoid activation of TRPV-like receptors. |
| Abstractor: | As Provided |
| Entry Date: | 2011 |
| Accession Number: | EJ937221 |
| Database: | ERIC |
| FullText | Text: Availability: 0 |
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| Header | DbId: eric DbLabel: ERIC An: EJ937221 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Associative, Bidirectional Changes in Neural Signaling Utilizing NMDA Receptor- and Endocannabinoid-Dependent Mechanisms – Name: Language Label: Language Group: Lang Data: English – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Li%2C+Qin%22">Li, Qin</searchLink><br /><searchLink fieldCode="AR" term="%22Burrell%2C+Brian+D%2E%22">Burrell, Brian D.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="SO" term="%22Learning+%26+Memory%22"><i>Learning & Memory</i></searchLink>. Sep 2011 18(9):545-553. – Name: Avail Label: Availability Group: Avail Data: Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/ – Name: PeerReviewed Label: Peer Reviewed Group: SrcInfo Data: Y – Name: PhysDesc Label: Physical Description Group: PhysDesc Data: PDF – Name: Pages Label: Page Count Group: Src Data: 9 – Name: DatePubCY Label: Publication Date Group: Date Data: 2011 – Name: TypeDocument Label: Document Type Group: TypDoc Data: Journal Articles<br />Reports - Research – Name: Subject Label: Descriptors Group: Su Data: <searchLink fieldCode="DE" term="%22Intervals%22">Intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Neurological+Organization%22">Neurological Organization</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+Hemisphere+Functions%22">Brain Hemisphere Functions</searchLink><br /><searchLink fieldCode="DE" term="%22Animals%22">Animals</searchLink><br /><searchLink fieldCode="DE" term="%22Cytology%22">Cytology</searchLink><br /><searchLink fieldCode="DE" term="%22Physiology%22">Physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Neurology%22">Neurology</searchLink> – Name: DOI Label: DOI Group: ID Data: 10.1101/lm.2252511 – Name: ISSN Label: ISSN Group: ISSN Data: 1072-0502 – Name: Abstract Label: Abstract Group: Ab Data: Persistent, bidirectional changes in synaptic signaling (that is, potentiation and depression of the synapse) can be induced by the precise timing of individual pre- and postsynaptic action potentials. However, far less attention has been paid to the ability of paired trains of action potentials to elicit persistent potentiation or depression. We examined plasticity following the pairing of spike trains in the touch mechanosensory neuron (T cell) and S interneuron (S cell) in the medicinal leech. Long-term potentiation (LTP) of T to S signaling was elicited when the T-cell spike train preceded the S-cell train. An interval 0 to +1 sec between the T- and S-cell spike trains was required to elicit long-term potentiation (LTP), and this potentiation was NMDA receptor (NMDAR)-dependent. Long-term depression (LTD) was elicited when S-cell activity preceded T-cell activity and the interval between the two spike trains was -0.2 sec to -10 sec. This surprisingly broad temporal window involved two distinct cellular mechanisms; an NMDAR-mediated LTD (NMDAR-LTD) when the pairing interval was relatively brief (less than -1 sec) and an endocannabinoid-mediated LTD (eCB-LTD) when longer pairing intervals were used (-1 to -10 sec). This eCB-LTD also required activation of a presynaptic transient receptor potential vanilloid (TRPV)-like receptor, presynaptic Ca[subscript 2+] release from intracellular stores and activation of voltage-gated Ca[subscript 2+] channels (VGCCs). These findings demonstrate that the pairing of spike trains elicits timing-dependent forms of LTP and LTD that are supported by a complex set of cellular mechanisms involving NMDARs and endocannabinoid activation of TRPV-like receptors. – Name: AbstractInfo Label: Abstractor Group: Ab Data: As Provided – Name: DateEntry Label: Entry Date Group: Date Data: 2011 – Name: AN Label: Accession Number Group: ID Data: EJ937221 |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=eric&AN=EJ937221 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1101/lm.2252511 Languages: – Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 545 Subjects: – SubjectFull: Intervals Type: general – SubjectFull: Neurological Organization Type: general – SubjectFull: Brain Hemisphere Functions Type: general – SubjectFull: Animals Type: general – SubjectFull: Cytology Type: general – SubjectFull: Physiology Type: general – SubjectFull: Neurology Type: general Titles: – TitleFull: Associative, Bidirectional Changes in Neural Signaling Utilizing NMDA Receptor- and Endocannabinoid-Dependent Mechanisms Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Li, Qin – PersonEntity: Name: NameFull: Burrell, Brian D. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 1072-0502 Numbering: – Type: volume Value: 18 – Type: issue Value: 9 Titles: – TitleFull: Learning & Memory Type: main |
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