Esclerosis múltiple: enfermedad neurológica de alto impacto social.
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| Title: | Esclerosis múltiple: enfermedad neurológica de alto impacto social. |
|---|---|
| Alternate Title: | Multiple sclerosis: neurological disease with high social impact. Back to the old treatment. |
| Authors: | Guadarrama-Ortiz, Parménides1, Guerra, Ximena Regalado2, Castillo-Rangel, Carlos3,4, Ángeles-Castellanos, Manuel2 |
| Source: | Revista de la Facultad de Medicina de la UNAM. nov/dic2014, Vol. 57 Issue 6, p5-10. 6p. |
| Subjects: | MULTIPLE sclerosis treatment, METHYLPREDNISOLONE, MULTIPLE sclerosis, NEURODEGENERATION, MYELINATION, MAGNETIC resonance imaging, PATIENTS, PREVENTION, THERAPEUTICS |
| Abstract (English): | Multiple sclerosis (MS) is a chronic inflammatory and im- mune-degenerative disease that affects young people and has a high social impact due to direct and indirect costs. Objective: Regulate neurodegenerative process through a suitable modulation of inflammatory factors by using meth- ylprednisolone and evaluation with Magnetic Resonance studies. Patients and methods: Female patients between the 1st and 5th decade of life, with diagnosis of Multiple Sclerosis, were included in the study if they met the criteria of McDonal 2010 (specially space and time monitoring) methylprednisolone boluses were administered regularly, even when the patient had no relapses, and the patients were then evaluated with Magnetic Resonance per annum, with a follow-up of up to 15 years. Results: There is a marked decrease of lesion in function of time and the bolus administration of methylprednisolone, and lesions disappeared entirely after 3 to 10 years of administration. Conclusions: The regular bolus administration of methylprednisolone attenuates the inflammatory process and the damage to the blood brain barrier and thus contributes in preventing neurodegeneration and is coadyuvant in remyelination. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | La esclerosis múltiple (EM) es una enfermedad inmune-inflamatoria y crónico-degenerativa, que afecta a personas jóvenes y tiene un alto impacto social por los costos directos e indirectos. Objetivo: Regular el proceso neurodegenerativo a través de una adecuada modulación de los factores inflamatorios mediante el uso de metilprednisolona y la evaluación con estudios de resonancia magnética. Pacientes y métodos: Pacientes mujeres que se encuentran entre la 1ª y 5ª década de la vida, con diagnóstico de EM, que se incluyeron por cumplir con los criterios diagnósticos de McDonald 2010 (sobre todo la diseminación en tiempo y espacio). Se les administraron bolos de metilprednisolona de manera regular, aun cuando no presentaran recaídas y se evaluaron con estudios de resonancia magnética (RM) anual, con un seguimiento de hasta 15 años. Resultados: Se observa una marcada disminución de las lesiones en función del tiempo y la administración de los bolos de metilprednisolona, y entre los 3 y 10 años las lesiones desaparecen en su totalidad. Conclusiones: La administración de bolos de metilprednisolona de manera regular atenúa el proceso inflamatorio y el daño a la barrera hematoencefálica, y por lo tanto, coadyuva en la remielinización y previene la neurodegeneración. [ABSTRACT FROM AUTHOR] |
| Copyright of Revista de la Facultad de Medicina de la UNAM is the property of UNAM, Facultad de Medicina and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
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| Header | DbId: lth DbLabel: MedicLatina An: 100786066 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Esclerosis múltiple: enfermedad neurológica de alto impacto social. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Multiple sclerosis: neurological disease with high social impact. Back to the old treatment. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Guadarrama-Ortiz%2C+Parménides%22">Guadarrama-Ortiz, Parménides</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Guerra%2C+Ximena+Regalado%22">Guerra, Ximena Regalado</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Castillo-Rangel%2C+Carlos%22">Castillo-Rangel, Carlos</searchLink><relatesTo>3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Ángeles-Castellanos%2C+Manuel%22">Ángeles-Castellanos, Manuel</searchLink><relatesTo>2</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Revista+de+la+Facultad+de+Medicina+de+la+UNAM%22">Revista de la Facultad de Medicina de la UNAM</searchLink>. nov/dic2014, Vol. 57 Issue 6, p5-10. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22MULTIPLE+sclerosis+treatment%22">MULTIPLE sclerosis treatment</searchLink><br /><searchLink fieldCode="DE" term="%22METHYLPREDNISOLONE%22">METHYLPREDNISOLONE</searchLink><br /><searchLink fieldCode="DE" term="%22MULTIPLE+sclerosis%22">MULTIPLE sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22NEURODEGENERATION%22">NEURODEGENERATION</searchLink><br /><searchLink fieldCode="DE" term="%22MYELINATION%22">MYELINATION</searchLink><br /><searchLink fieldCode="DE" term="%22MAGNETIC+resonance+imaging%22">MAGNETIC resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22PATIENTS%22">PATIENTS</searchLink><br /><searchLink fieldCode="DE" term="%22PREVENTION%22">PREVENTION</searchLink><br /><searchLink fieldCode="DE" term="%22THERAPEUTICS%22">THERAPEUTICS</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Multiple sclerosis (MS) is a chronic inflammatory and im- mune-degenerative disease that affects young people and has a high social impact due to direct and indirect costs. Objective: Regulate neurodegenerative process through a suitable modulation of inflammatory factors by using meth- ylprednisolone and evaluation with Magnetic Resonance studies. Patients and methods: Female patients between the 1st and 5th decade of life, with diagnosis of Multiple Sclerosis, were included in the study if they met the criteria of McDonal 2010 (specially space and time monitoring) methylprednisolone boluses were administered regularly, even when the patient had no relapses, and the patients were then evaluated with Magnetic Resonance per annum, with a follow-up of up to 15 years. Results: There is a marked decrease of lesion in function of time and the bolus administration of methylprednisolone, and lesions disappeared entirely after 3 to 10 years of administration. Conclusions: The regular bolus administration of methylprednisolone attenuates the inflammatory process and the damage to the blood brain barrier and thus contributes in preventing neurodegeneration and is coadyuvant in remyelination. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: La esclerosis múltiple (EM) es una enfermedad inmune-inflamatoria y crónico-degenerativa, que afecta a personas jóvenes y tiene un alto impacto social por los costos directos e indirectos. Objetivo: Regular el proceso neurodegenerativo a través de una adecuada modulación de los factores inflamatorios mediante el uso de metilprednisolona y la evaluación con estudios de resonancia magnética. Pacientes y métodos: Pacientes mujeres que se encuentran entre la 1ª y 5ª década de la vida, con diagnóstico de EM, que se incluyeron por cumplir con los criterios diagnósticos de McDonald 2010 (sobre todo la diseminación en tiempo y espacio). Se les administraron bolos de metilprednisolona de manera regular, aun cuando no presentaran recaídas y se evaluaron con estudios de resonancia magnética (RM) anual, con un seguimiento de hasta 15 años. Resultados: Se observa una marcada disminución de las lesiones en función del tiempo y la administración de los bolos de metilprednisolona, y entre los 3 y 10 años las lesiones desaparecen en su totalidad. Conclusiones: La administración de bolos de metilprednisolona de manera regular atenúa el proceso inflamatorio y el daño a la barrera hematoencefálica, y por lo tanto, coadyuva en la remielinización y previene la neurodegeneración. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Revista de la Facultad de Medicina de la UNAM is the property of UNAM, Facultad de Medicina and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 6 StartPage: 5 Subjects: – SubjectFull: MULTIPLE sclerosis treatment Type: general – SubjectFull: METHYLPREDNISOLONE Type: general – SubjectFull: MULTIPLE sclerosis Type: general – SubjectFull: NEURODEGENERATION Type: general – SubjectFull: MYELINATION Type: general – SubjectFull: MAGNETIC resonance imaging Type: general – SubjectFull: PATIENTS Type: general – SubjectFull: PREVENTION Type: general – SubjectFull: THERAPEUTICS Type: general Titles: – TitleFull: Esclerosis múltiple: enfermedad neurológica de alto impacto social. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Guadarrama-Ortiz, Parménides – PersonEntity: Name: NameFull: Guerra, Ximena Regalado – PersonEntity: Name: NameFull: Castillo-Rangel, Carlos – PersonEntity: Name: NameFull: Ángeles-Castellanos, Manuel IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: nov/dic2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 00261742 Numbering: – Type: volume Value: 57 – Type: issue Value: 6 Titles: – TitleFull: Revista de la Facultad de Medicina de la UNAM Type: main |
| ResultId | 1 |
