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Comparison of the efficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphine-induced pruritus.

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Title: Comparison of the efficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphine-induced pruritus.
Authors: Cruz-Ferretti, U.1 drferretti@hotmail.com, Llanes-Garza, H. A.1, López-Cabrera, N. G.1, Espinosa-Galindo, A. M.1, Palacios-Ríos, D.1, Cano-García, M. A.1, Estrada-Solís, Y. N.1
Source: Medicina Universitaria. jul-sep2014, Vol. 16 Issue 64, p107-111. 5p.
Subjects: ONDANSETRON, NALBUPHINE, ITCHING, MORPHINE, ANALGESIA, PHYSIOLOGY, THERAPEUTICS
Abstract: Objective: To compare the efficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphine-induced pruritus, in patients at the "Dr. José Eleuterio González" University Hospital from September 2012 to August 2013. Material and methods: A controlled, prospective, randomized study of 28 patients (14 per group) receiving neuraxial morphine analgesia was conducted, which was registered and approved by the Ethics Committee of the Institution and patients agreed to participate in the study under informed consent. The results were segmented and contrasted (according to drug) by hypothesis testing; the association was determined by X² with a 95% confidence interval (CI). Results: Pruritus was effectively resolved in both groups and no significant difference was found in the rest of the variables. An increase in the visual analogue scale (EVA) was observed at 6 and 12 hours for the ondansetron group, which was statistically significant (p≤0.05), however both groups had an EVA of less than 3. Conclusions: When comparing the efficacy and safety of ondansetron 4 mg vs. nalbuphine 4 mg for the treatment of neuraxial morphine induced pruritus, the only significant difference found was the mean EVA at 6 and 12 hours, favoring the ondansetron group. However, both groups scored less than 3 on the EVA. Therefore, we consider that both treatments are effective and safe in the treatment of pruritus caused by neuraxial morphine. [ABSTRACT FROM AUTHOR]
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Abstract:Objective: To compare the efficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphine-induced pruritus, in patients at the "Dr. José Eleuterio González" University Hospital from September 2012 to August 2013. Material and methods: A controlled, prospective, randomized study of 28 patients (14 per group) receiving neuraxial morphine analgesia was conducted, which was registered and approved by the Ethics Committee of the Institution and patients agreed to participate in the study under informed consent. The results were segmented and contrasted (according to drug) by hypothesis testing; the association was determined by X² with a 95% confidence interval (CI). Results: Pruritus was effectively resolved in both groups and no significant difference was found in the rest of the variables. An increase in the visual analogue scale (EVA) was observed at 6 and 12 hours for the ondansetron group, which was statistically significant (p≤0.05), however both groups had an EVA of less than 3. Conclusions: When comparing the efficacy and safety of ondansetron 4 mg vs. nalbuphine 4 mg for the treatment of neuraxial morphine induced pruritus, the only significant difference found was the mean EVA at 6 and 12 hours, favoring the ondansetron group. However, both groups scored less than 3 on the EVA. Therefore, we consider that both treatments are effective and safe in the treatment of pruritus caused by neuraxial morphine. [ABSTRACT FROM AUTHOR]
ISSN:16655796