Bibliographic Details
| Title: |
Demostración y caracterización in silico del fenómeno de resonancia estocástica en sinapsis nociceptivas del tipo NMDA del asta dorsal medular. |
| Alternate Title: |
In silico demonstration and characterization of the stochastic resonance phenomena in a NMDA type nociceptive synapsis of the spinal dorsal horn. |
| Authors: |
Henríquez, Yohani1, Eblen-Zajjur, Antonio1 aeblen@uc.edu.ve |
| Source: |
Archivos de Neurociencias. oct-dic2014, Vol. 19 Issue 4, p182-189. 8p. 1 Black and White Photograph, 3 Charts, 6 Graphs. |
| Subjects: |
NOCICEPTORS, STOCHASTIC resonance, METHYL aspartate receptors, ELECTRIC stimulation, NEURAL transmission, NEURONS, NOISE |
| Abstract (English): |
Aim: nociceptive primary afferents establish synapses in the spinal dorsal horn (SDH) expressing mainly glutamatergic strongly excitatory NMDA type ionotropic channels. SDH postsynaptic neurons generate discharges inmersed in different noise levels which is classically considerated a signal transmission adverse factor. Material and method: in the present study, the effects of different noise levels (NL) was evaluated on a experimentally described model of NMDA type synapse between nociceptive SDH neurons. Pre and postsinaptic number of spikes, interspike intervals (ISI) and the post/presynaptic spike quotient were studied with a neuronal network simulator (Neurosim: Network v 1.2a.). The NL was progresssively increased (0 to ±5mV) in both spontaneous activity and evoked by a electrical stimulus (pulse ±29nA). Results: It was found a proportional increase of synaptic efficiency with NL with a logaríthmic function: Post/Pre Spike Quotient = 3,38+0,26NL- 0,029NL² (r=+0,67; P<0,05), the ISI for presynaptic: ISI = 14,33- 1,33NL+0,06NL² but also postsynaptic: ISI= 6,66- 0,85NL+0,06NL² showed a proportional decrease with NL (r=-0,72 and r=-0,79; respectively P<0,05). Conclusion: these results strongly suggest, for the first time, that the NL increases the synaptic efficiency in the model of NMDA type synapse between nociceptive SDH neurons, this phenomenon of interest in nociception, named stochastic resonance, was described first in others places of the central nervous system. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
Objetivo: los aferentes primarios nociceptivos establecen sinapsis en el asta dorsal medular (ADM) expresando predominantemente canales glutamatérgicos ionotrópicos del tipo NMDA intensamente excitatorios. Las neuronas posinápticas del ADM generan descargas inmersas en diferentes niveles de ruido, el cual, clásicamente es considerado como factor que afecta la señal transmitida. Material y métodos: en el presente estudio se evaluó el efecto de diferentes niveles de ruido en sinapsis NMDA de neuronas nociceptivas del ADM sobre el número de espigas e intervalo interespiga (IIE), mediante el simulador de redes neuronales neurosim: network v 1. 2 a. usando un modelo sináptico NMDA ajustado a las descripciones experimentales del asta dorsal medular se incrementó el nivel de ruido (NR) progresivamente de 0 a ±5mV en actividad espontánea como estimulada con un pulso de ±29nA. Se evaluó el número de descargas pre, posinápticas, cociente y los IIE para cada NR pre o posináptico. Resultados: existe un incremento de la eficiencia sináptica proporcional al NR siguiendo una función logarítmica: cociente de descargas pos/pre = 3,38+0,26NR-0,029NR² (r=+0,67; P<0,05). Los IIE tanto pre: IIE = 14,33-1,33NR+0,06NR² como posinápticos: IIE= 6,66-0,85NR+0,06NR² mostraron una reducción proporcional al NR (r=-0,72 y r=-0,79; respectivamente P<0,05). Conclusiones: estos resultados sugieren que el incremento del NR en el modelo de sinapsis tipo NMDA del ADM incrementa la eficiencia sináptica este fenómeno, de interés en nocicepción, se denomina resonancia estocástica, ha sido descrito en otras partes del sistema nervioso central. [ABSTRACT FROM AUTHOR] |
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| Database: |
MedicLatina |
