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Mast cell activation disease associated with autoimmune thyroid disease: case report and review of literature.

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Title: Mast cell activation disease associated with autoimmune thyroid disease: case report and review of literature.
Authors: Rojas, Joselyn1,2 rojas.joselyn@gmail.com, Calvo Delgado, María José1, Chávez, Carmen1, Chávez-Castillo, Mervin1, Mejía, Lidia1, Salazar, Juan1, Olivar, Luis1, Graterol-Rivas, Modesto3, Wilches-Duran, Sandra3, Contreras-Velásquez, Julio3, Graterol-Silva, Rosemily3, Bermúdez, Valmore1
Source: Archivos Venezolanos de Farmacología y Terapéutica. 2016, Vol. 35 Issue 4, p92-99. 8p.
Subjects: MAST cells, THYROID diseases, CELL proliferation, ANGIONEUROTIC edema, HYPOTENSION
Abstract: Mast Cell Activation Disease (MCAD) is characterized by abnormal proliferation of mastocytes, where clinical manifestations arise from the excess release of these cells' mediators. This case report concerns a 34-year old male patient who seeks medical attention after 5 months presenting recurring episodes of intense facial flushing with local edema, erythema, and increased volume of the ears and lips, without signs of angioedema. Other symptoms included burning oropharyngeal pain, vascular-type headache and hypotension. These crises occurred predominantly during nighttime and lasted 20-60 minutes, and were often associated with prolonged exposure to sunlight, high temperatures and psychological stress; constituting a clinical picture compatible with MCAD, supported by laboratory findings. Treatment began with ebastine, deflazacort, montelukast, ranitidine and omega-3 fatty acids, without clinical improvement, leading to substitution of this regimen with sodium chromoglycate and initiation of an immunomodulatory diet. This plan achieved satisfactory symptomatic resolution, confirming the diagnosis and highlighting the importance of adequate pharmacologic intervention. During a control consultation, the patient reported nocturnal episodes of tachycardia, palpitations and anxiety unrelated to the flushing crises, which prompted thyroid evaluation, revealing autoimmune thyroid disease with subclinical hyperthyroidism, which was managed with methimazol without complications. [ABSTRACT FROM AUTHOR]
Copyright of Archivos Venezolanos de Farmacología y Terapéutica is the property of Archivos Venezolanos de Farmacologia y Terapeutica and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Mast cell activation disease associated with autoimmune thyroid disease: case report and review of literature.
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  Data: <searchLink fieldCode="AR" term="%22Rojas%2C+Joselyn%22">Rojas, Joselyn</searchLink><relatesTo>1,2</relatesTo><i> rojas.joselyn@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Calvo+Delgado%2C+María+José%22">Calvo Delgado, María José</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Chávez%2C+Carmen%22">Chávez, Carmen</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Chávez-Castillo%2C+Mervin%22">Chávez-Castillo, Mervin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Mejía%2C+Lidia%22">Mejía, Lidia</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Salazar%2C+Juan%22">Salazar, Juan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Olivar%2C+Luis%22">Olivar, Luis</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Graterol-Rivas%2C+Modesto%22">Graterol-Rivas, Modesto</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Wilches-Duran%2C+Sandra%22">Wilches-Duran, Sandra</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Contreras-Velásquez%2C+Julio%22">Contreras-Velásquez, Julio</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Graterol-Silva%2C+Rosemily%22">Graterol-Silva, Rosemily</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Bermúdez%2C+Valmore%22">Bermúdez, Valmore</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="DE" term="%22MAST+cells%22">MAST cells</searchLink><br /><searchLink fieldCode="DE" term="%22THYROID+diseases%22">THYROID diseases</searchLink><br /><searchLink fieldCode="DE" term="%22CELL+proliferation%22">CELL proliferation</searchLink><br /><searchLink fieldCode="DE" term="%22ANGIONEUROTIC+edema%22">ANGIONEUROTIC edema</searchLink><br /><searchLink fieldCode="DE" term="%22HYPOTENSION%22">HYPOTENSION</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Mast Cell Activation Disease (MCAD) is characterized by abnormal proliferation of mastocytes, where clinical manifestations arise from the excess release of these cells' mediators. This case report concerns a 34-year old male patient who seeks medical attention after 5 months presenting recurring episodes of intense facial flushing with local edema, erythema, and increased volume of the ears and lips, without signs of angioedema. Other symptoms included burning oropharyngeal pain, vascular-type headache and hypotension. These crises occurred predominantly during nighttime and lasted 20-60 minutes, and were often associated with prolonged exposure to sunlight, high temperatures and psychological stress; constituting a clinical picture compatible with MCAD, supported by laboratory findings. Treatment began with ebastine, deflazacort, montelukast, ranitidine and omega-3 fatty acids, without clinical improvement, leading to substitution of this regimen with sodium chromoglycate and initiation of an immunomodulatory diet. This plan achieved satisfactory symptomatic resolution, confirming the diagnosis and highlighting the importance of adequate pharmacologic intervention. During a control consultation, the patient reported nocturnal episodes of tachycardia, palpitations and anxiety unrelated to the flushing crises, which prompted thyroid evaluation, revealing autoimmune thyroid disease with subclinical hyperthyroidism, which was managed with methimazol without complications. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Archivos Venezolanos de Farmacología y Terapéutica is the property of Archivos Venezolanos de Farmacologia y Terapeutica and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 92
    Subjects:
      – SubjectFull: MAST cells
        Type: general
      – SubjectFull: THYROID diseases
        Type: general
      – SubjectFull: CELL proliferation
        Type: general
      – SubjectFull: ANGIONEUROTIC edema
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      – SubjectFull: HYPOTENSION
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              Text: 2016
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