MDRD o CKD-EPI en la estimación del filtrado glomerular del donante renal vivo.
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| Title: | MDRD o CKD-EPI en la estimación del filtrado glomerular del donante renal vivo. |
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| Alternate Title: | MDRD or CKD-EPI for glomerular filtration rate estimation in living kidney donors. |
| Authors: | Burballa, Carla1, Crespo, Marta1, Redondo-Pachón, Dolores1, Pérez-Sáez, María José1, Mir, Marisa1, Arias-Cabrales, Carlos1, Francés, Albert2, Fumadó, Lluis2, Cecchini, Lluis2, Pascual, Julio1 |
| Source: | Nefrologia. 2018, Vol. 38 Issue 2, p207-212. 6p. |
| Abstract (English): | Introduction: The evaluation of the measured Glomerular Filtration Rate (mGFR) or estimated Glomerular Filtration Rate (eGFR) is key in the proper assessment of the renal function of potential kidney donors. We aim to study the correlation between glomerular filtration rate estimation equations and the measured methods for determining renal function. Material and methods: We analysed the relationship between baseline GFR values measured by Tc-99m-DTPA (diethylene-triamine-pentaacetate) and those estimated by the four-variable Modification of Diet in Renal Disease (MDRD4) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in a series of living donors at our institution. Results: We included 64 donors (70.6% females; mean age 48.3 ± 11 years). Baseline creatinine was 0.8 ± 0.1 mg/dl and it was 1.1 ± 0.2 mg/dl one year after donation. The equations underestimated GFR when measured by Tc99m-DTPA (MDRD4-9.4 ± 25 ml/min, P<.05, and CKD-EPI-4.4 ± 21 ml/min). The correlation between estimation equations and the measured method was superior for CKD-EPI (r=.41; P<.004) than for MDRD4 (r=.27; P<.05). eGFR decreased to 59.6 ± 11 (MDRD4) and 66.2 ± 14 ml/min (CKD-EPI) one year after donation. This means a mean eGFR reduction of 28.2 ± 16.7 ml/min (MDRD4) and 27.31 ± 14.4 ml/min (CKD-EPI) at one year. Conclusions: In our experience, CKD-EPI is the equation that better correlates with mGFR-Tc99m-DTPA when assessing renal function for donor screening purposes. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Introducción: El estudio del filtrado glomerular medido (FGm) o del estimado (FGe) es el eje de la evaluación adecuada de la función renal en la valoración de un potencial donante vivo renal. Nos planteamos estudiar la correlación entre las fórmulas de estimación del FG y los métodos de medición para determinar la función renal. Material y métodos: Analizamos la relación entre los valores basales de FGm con Tc-99m-DTPA (dietilenolene-triamino-pentaacetato) y aquellos estimados mediante las fórmulas Modifi- cation Diet Renal Disease de 4 variables (MDRD4) y Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) en una serie de donantes vivos de nuestra institución. Resultados: Incluimos a 64 donantes (70,6% mujeres; con una edad media de 48,3 ± 11 añnos). La creatinina basal fue 0,8 ± 0,1 y 1,1 ± 0,2 mg/dl un añno posdonación. Las ecuaciones infraestiman el FG medido por Tc99m-DTPA (MDRD4 -9,4 ± 25 ml/min y p < 0,05; CKD-EPI -4,4 ± 21 ml/min). La correlación entre las fórmulas estimativas y el método medido fue superior para CKD-EPI (r = 0,41; p = 0,004) que para MDRD4 (r = 0,27; p = 0,05). El FGe se redujo a 59,6 ± 11 (MDRD4) y a 66,2 ± 14 ml/min (CKD-EPI) al año posdonación. Esto supone una reducción media del FGe de 28,2 ± 16,7 ml/min (MDRD4) y de 27,31 ± 14,4 ml/min (CKD-EPI) al año. Conclusión: En nuestra experiencia, CKD-EPI es la fórmula que mejor se correlaciona con el FGm-Tc99m-DTPA en la evaluación de la función renal para el cribado de donantes. [ABSTRACT FROM AUTHOR] |
| Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: MDRD o CKD-EPI en la estimación del filtrado glomerular del donante renal vivo. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: MDRD or CKD-EPI for glomerular filtration rate estimation in living kidney donors. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Burballa%2C+Carla%22">Burballa, Carla</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Crespo%2C+Marta%22">Crespo, Marta</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Redondo-Pachón%2C+Dolores%22">Redondo-Pachón, Dolores</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Pérez-Sáez%2C+María+José%22">Pérez-Sáez, María José</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Mir%2C+Marisa%22">Mir, Marisa</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Arias-Cabrales%2C+Carlos%22">Arias-Cabrales, Carlos</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Francés%2C+Albert%22">Francés, Albert</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Fumadó%2C+Lluis%22">Fumadó, Lluis</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Cecchini%2C+Lluis%22">Cecchini, Lluis</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Pascual%2C+Julio%22">Pascual, Julio</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nefrologia%22">Nefrologia</searchLink>. 2018, Vol. 38 Issue 2, p207-212. 6p. – Name: Abstract Label: Abstract (English) Group: Ab Data: Introduction: The evaluation of the measured Glomerular Filtration Rate (mGFR) or estimated Glomerular Filtration Rate (eGFR) is key in the proper assessment of the renal function of potential kidney donors. We aim to study the correlation between glomerular filtration rate estimation equations and the measured methods for determining renal function. Material and methods: We analysed the relationship between baseline GFR values measured by Tc-99m-DTPA (diethylene-triamine-pentaacetate) and those estimated by the four-variable Modification of Diet in Renal Disease (MDRD4) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in a series of living donors at our institution. Results: We included 64 donors (70.6% females; mean age 48.3 ± 11 years). Baseline creatinine was 0.8 ± 0.1 mg/dl and it was 1.1 ± 0.2 mg/dl one year after donation. The equations underestimated GFR when measured by Tc99m-DTPA (MDRD4-9.4 ± 25 ml/min, P<.05, and CKD-EPI-4.4 ± 21 ml/min). The correlation between estimation equations and the measured method was superior for CKD-EPI (r=.41; P<.004) than for MDRD4 (r=.27; P<.05). eGFR decreased to 59.6 ± 11 (MDRD4) and 66.2 ± 14 ml/min (CKD-EPI) one year after donation. This means a mean eGFR reduction of 28.2 ± 16.7 ml/min (MDRD4) and 27.31 ± 14.4 ml/min (CKD-EPI) at one year. Conclusions: In our experience, CKD-EPI is the equation that better correlates with mGFR-Tc99m-DTPA when assessing renal function for donor screening purposes. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Introducción: El estudio del filtrado glomerular medido (FGm) o del estimado (FGe) es el eje de la evaluación adecuada de la función renal en la valoración de un potencial donante vivo renal. Nos planteamos estudiar la correlación entre las fórmulas de estimación del FG y los métodos de medición para determinar la función renal. Material y métodos: Analizamos la relación entre los valores basales de FGm con Tc-99m-DTPA (dietilenolene-triamino-pentaacetato) y aquellos estimados mediante las fórmulas Modifi- cation Diet Renal Disease de 4 variables (MDRD4) y Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) en una serie de donantes vivos de nuestra institución. Resultados: Incluimos a 64 donantes (70,6% mujeres; con una edad media de 48,3 ± 11 añnos). La creatinina basal fue 0,8 ± 0,1 y 1,1 ± 0,2 mg/dl un añno posdonación. Las ecuaciones infraestiman el FG medido por Tc99m-DTPA (MDRD4 -9,4 ± 25 ml/min y p < 0,05; CKD-EPI -4,4 ± 21 ml/min). La correlación entre las fórmulas estimativas y el método medido fue superior para CKD-EPI (r = 0,41; p = 0,004) que para MDRD4 (r = 0,27; p = 0,05). El FGe se redujo a 59,6 ± 11 (MDRD4) y a 66,2 ± 14 ml/min (CKD-EPI) al año posdonación. Esto supone una reducción media del FGe de 28,2 ± 16,7 ml/min (MDRD4) y de 27,31 ± 14,4 ml/min (CKD-EPI) al año. Conclusión: En nuestra experiencia, CKD-EPI es la fórmula que mejor se correlaciona con el FGm-Tc99m-DTPA en la evaluación de la función renal para el cribado de donantes. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.nefro.2017.02.007 Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 6 StartPage: 207 Titles: – TitleFull: MDRD o CKD-EPI en la estimación del filtrado glomerular del donante renal vivo. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Burballa, Carla – PersonEntity: Name: NameFull: Crespo, Marta – PersonEntity: Name: NameFull: Redondo-Pachón, Dolores – PersonEntity: Name: NameFull: Pérez-Sáez, María José – PersonEntity: Name: NameFull: Mir, Marisa – PersonEntity: Name: NameFull: Arias-Cabrales, Carlos – PersonEntity: Name: NameFull: Francés, Albert – PersonEntity: Name: NameFull: Fumadó, Lluis – PersonEntity: Name: NameFull: Cecchini, Lluis – PersonEntity: Name: NameFull: Pascual, Julio IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 2018 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 02116995 Numbering: – Type: volume Value: 38 – Type: issue Value: 2 Titles: – TitleFull: Nefrologia Type: main |
| ResultId | 1 |
