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Venlafaxine titration dosage in depressive in-patients. A series of cases.

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Title: Venlafaxine titration dosage in depressive in-patients. A series of cases.
Authors: Durán, A., Bernardo, M., Gascón, J., Prieto, R., Alberni, J., Buisán, E.
Source: Actas Espanolas de Psiquiatria. jan2003, Vol. 31 Issue 1, p31-34. 4p.
Subjects: VENLAFAXINE, MENTAL depression, INPATIENT care, ANTIDEPRESSANTS, VOLUMETRIC analysis, THERAPEUTICS, CLINICAL medicine
Abstract (English): This series of patients was gathered to assess the use of last and slow titration dosage of venlafaxine in in-patients with major depression and to evaluate tile action onset. An observational open study was performed in 3 centers in 18 in-patients. Nine patients were included in fast titration dosage group (ET) and 9 in slow titration dosage group (ST). As results, it was found that the ET group showed faster improvement than the ST group in the Hamilton scale for depression (HAM-D) score. This improvement was sustained to the final visit, with a lower score in the ET group (6.75) than the ST group (10.67). The Montgomery and Asberg depression rating scale (MADRS) scores up to the 15th visit were similar; however, the score was lower in the ST group on the 20th visit Improvement was sustained to the final visit, the FT group score being lower (6.50) than the ST group score (14). The Clinical Global Impression scale (CGI) improvement and CGI-severity scores were similar to the above mentioned results. The most common events in both groups were considered mild. The data of these patients show faster response to antidepressant therapy with faster titration dosage, with maintenance of the molecule's tolerability profile. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Esta serie de pacientes se ha recogido para evaluar el uso en escalada rápida y lenta de venlafaxina en el tratamiento de la depresión en pacientes hospitaiizados y valorar en qué momento empieza la respuesta al tratamiento. Se realiza con diseño de un estudio abierto, observacional, realizado en tres centros hospitalarios de Barcelona. De los 18 pacientes incluidos, nueve son del grupo de escalada rápida (ER) y nueve de escalada lenta (EL). Se obtiene que el grupo ER muestra una mejoría más rápida que el grupo EL en la escala de Hamilton para la depresión (HAM-D). Dicha mejoría se ha mantenido hasta la visita final, con puntuaciones más tjajas el grupo de ER (6,75) que el grupo de EL (10,67). En la escala de Montgomery y Asberg para la depresión (MADRS) las puntuaciones para ambos grupos han sido similares hasta la visita 15, mientras que en la visita 20 la puntuación ha sido más baja en ei grupo EL. Se ha mantenido la mejoría en la visita final, siendo el grupo de ER el que ha puntuado más bajo (6,50 frente a 14 del grupo de EL). Esto mismo se ha observado en la valoración de gravedad y mejoría en la escala de Impresión Clínica Global (CGI). En cuanto a la tolerancia, las reacciones adversas con venlafaxina en ambos grupos han sido en general leves. Los datos de esta serie de pacientes muestran una respuesta más rápida cuando se aumenta la dosis más rápidamente, manteniéndose el perfil de tolerancia de la molécula. [ABSTRACT FROM AUTHOR]
Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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PubType: Academic Journal
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  Data: Venlafaxine titration dosage in depressive in-patients. A series of cases.
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  Data: <searchLink fieldCode="AR" term="%22Durán%2C+A%2E%22">Durán, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Bernardo%2C+M%2E%22">Bernardo, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Gascón%2C+J%2E%22">Gascón, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Prieto%2C+R%2E%22">Prieto, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Alberni%2C+J%2E%22">Alberni, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Buisán%2C+E%2E%22">Buisán, E.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Actas+Espanolas+de+Psiquiatria%22">Actas Espanolas de Psiquiatria</searchLink>. jan2003, Vol. 31 Issue 1, p31-34. 4p.
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  Data: <searchLink fieldCode="DE" term="%22VENLAFAXINE%22">VENLAFAXINE</searchLink><br /><searchLink fieldCode="DE" term="%22MENTAL+depression%22">MENTAL depression</searchLink><br /><searchLink fieldCode="DE" term="%22INPATIENT+care%22">INPATIENT care</searchLink><br /><searchLink fieldCode="DE" term="%22ANTIDEPRESSANTS%22">ANTIDEPRESSANTS</searchLink><br /><searchLink fieldCode="DE" term="%22VOLUMETRIC+analysis%22">VOLUMETRIC analysis</searchLink><br /><searchLink fieldCode="DE" term="%22THERAPEUTICS%22">THERAPEUTICS</searchLink><br /><searchLink fieldCode="DE" term="%22CLINICAL+medicine%22">CLINICAL medicine</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: This series of patients was gathered to assess the use of last and slow titration dosage of venlafaxine in in-patients with major depression and to evaluate tile action onset. An observational open study was performed in 3 centers in 18 in-patients. Nine patients were included in fast titration dosage group (ET) and 9 in slow titration dosage group (ST). As results, it was found that the ET group showed faster improvement than the ST group in the Hamilton scale for depression (HAM-D) score. This improvement was sustained to the final visit, with a lower score in the ET group (6.75) than the ST group (10.67). The Montgomery and Asberg depression rating scale (MADRS) scores up to the 15th visit were similar; however, the score was lower in the ST group on the 20th visit Improvement was sustained to the final visit, the FT group score being lower (6.50) than the ST group score (14). The Clinical Global Impression scale (CGI) improvement and CGI-severity scores were similar to the above mentioned results. The most common events in both groups were considered mild. The data of these patients show faster response to antidepressant therapy with faster titration dosage, with maintenance of the molecule's tolerability profile. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Esta serie de pacientes se ha recogido para evaluar el uso en escalada rápida y lenta de venlafaxina en el tratamiento de la depresión en pacientes hospitaiizados y valorar en qué momento empieza la respuesta al tratamiento. Se realiza con diseño de un estudio abierto, observacional, realizado en tres centros hospitalarios de Barcelona. De los 18 pacientes incluidos, nueve son del grupo de escalada rápida (ER) y nueve de escalada lenta (EL). Se obtiene que el grupo ER muestra una mejoría más rápida que el grupo EL en la escala de Hamilton para la depresión (HAM-D). Dicha mejoría se ha mantenido hasta la visita final, con puntuaciones más tjajas el grupo de ER (6,75) que el grupo de EL (10,67). En la escala de Montgomery y Asberg para la depresión (MADRS) las puntuaciones para ambos grupos han sido similares hasta la visita 15, mientras que en la visita 20 la puntuación ha sido más baja en ei grupo EL. Se ha mantenido la mejoría en la visita final, siendo el grupo de ER el que ha puntuado más bajo (6,50 frente a 14 del grupo de EL). Esto mismo se ha observado en la valoración de gravedad y mejoría en la escala de Impresión Clínica Global (CGI). En cuanto a la tolerancia, las reacciones adversas con venlafaxina en ambos grupos han sido en general leves. Los datos de esta serie de pacientes muestran una respuesta más rápida cuando se aumenta la dosis más rápidamente, manteniéndose el perfil de tolerancia de la molécula. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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    Languages:
      – Code: eng
        Text: English
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        PageCount: 4
        StartPage: 31
    Subjects:
      – SubjectFull: VENLAFAXINE
        Type: general
      – SubjectFull: MENTAL depression
        Type: general
      – SubjectFull: INPATIENT care
        Type: general
      – SubjectFull: ANTIDEPRESSANTS
        Type: general
      – SubjectFull: VOLUMETRIC analysis
        Type: general
      – SubjectFull: THERAPEUTICS
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      – SubjectFull: CLINICAL medicine
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      – TitleFull: Venlafaxine titration dosage in depressive in-patients. A series of cases.
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              Text: jan2003
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