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Factores asociados a la compensación de la función renal tras la nefrectomía para donación.

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Title: Factores asociados a la compensación de la función renal tras la nefrectomía para donación.
Alternate Title: Factors associated with renal function compensation after donor nephrectomy.
Authors: Burballa, Carla1, Crespo, Marta1, Redondo-Pachón, Dolores1, Pérez-Sáez, María José1, Arias-Cabrales, Carlos1, Mir, Marisa1, Francés, Albert2, Fumadób, Lluís2, Cecchini, Lluís2, Pascual, Julio2
Source: Nefrologia. 2018, Vol. 38 Issue 5, p528-534. 7p.
Abstract (English): Introduction: Kidney transplant donors lose 50% of their renal mass after nephrectomy. The remaining kidney compensates for this loss and it is estimated that 70% of the baseline renal function prior to donation is recovered. Factors associated with post-donation renal compensation are not well understood. Methods: Retrospective study of 66 consecutive kidney donors (mean age 48.8 years, 74.2% women). We analysed the potential factors associated with the compensatory mechanisms of the remaining kidney by comparing donors according to their renal compensation rate (RCR) (Group A, infra-compensation [< 70%]; Group B, normal compensation [> 70%]). Results: We compared Group A (n = 38) and group B (n = 28). Predictors for RCR > 70% were higher baseline creatinine (A vs B: 0.73 ± 0.14 vs 0.82 ± 0.11; P = .03) and a lower baseline glomerular filtration rate (GFR), estimated both by MDRD-4 (A vs B: 97.7 ± 18.8 vs 78.6 ± 9.6 ml/min; P < .001) and CKD-EPI (A vs B: 101.7 ± 15 vs. 88.3±11.7 ml/min; P ≤ .001). Age, gender, smoking, hypertension and GFR measured by Tc-DTPA did not show any correlation with the RCR. The multivariate analysis confirmed baseline estimated glomerular filtration rate (eGFR) to be a predictor of compensation: the higher the baseline eGFR, the lower the likelihood of > 70% compensation (MDRD-4, OR = 0.94 [95% CI 0.8--0.9], P = .01). The compensation rate decreased by 0.4% (P < .001) and 0.3% (P = .006) for every ml/min increase in baseline eGFR estimated by MDRD-4 and CKD-EPI, respectively. Conclusions: One year after living donor nephrectomy, the remaining kidney partially compensates baseline renal function. In our experience, baseline eGFR is inversely proportional to the one-year renal compensation rate. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción: Los donantes renales pierden la mitad de su masa renal tras la nefrectomía. Se estima que el riñón remanente compensa idóneamente un 70% de la función renal previa a la donación. Los factores asociados con el grado de compensación posdonación no están bien establecidos. Métodos: Análisis retrospectivo de 66 donantes renales consecutivos. Edad media 48,8 años; 74,2% mujeres. Se estudiaron los potenciales factores asociados con la compensación del riñón remanente comparando donantes según su tasa de compensación renal (TCR) (grupo A, infra-compensación [< 70%]; grupo B compensación normal [> 70%]). Resultados: Comparamos los grupos A (n = 38) y B (n = 28). Los factores predictores de una TCR > 70% fueron una mayor creatinina basal (A vs. B 0,73 ± 0,14 vs. 0,82 ± 0,11; p = 0,03) y menor filtrado glomerular (FG), tanto estimado mediante MDRD-4 (A vs. B 97,7 ± 18,8 vs. 78,6 ± 9,6 ml/min; p < 0,001) como por CKD-EPI (A vs. B 101,7 ± 15 vs. 88,3 ± 11,7 ml/min; p ≤ 0,001). La edad, el sexo, el tabaquismo, la hipertensión o el FG medido con Tcm-DTPA no mostraron asociación con la TCR. El análisis multivariante confirmó el FGe como predictor de compensación: a mayor FG basal menor probabilidad de compensar > 70% (MDRD-4, odds ratio [OR] = 0,94 [IC 95%: 0,8-0,9], p = 0,01). La tasa de compensación era 0,4% (p < 0,001) y 0,3% (p = 0,006), menor por cada ml/min de FG basal más, por MDRD-4 y CKD-EPI respectivamente. Conclusiones: Un año después de la donación renal el riñón remanente compensa parcialmente la función renal basal. En nuestra experiencia el FGe basal se asocia de forma inversamente proporcional a la tasa de compensación renal al año. [ABSTRACT FROM AUTHOR]
Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Factores asociados a la compensaci&#243;n de la funci&#243;n renal tras la nefrectom&#237;a para donaci&#243;n.
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  Data: Factors associated with renal function compensation after donor nephrectomy.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Burballa%2C+Carla%22&quot;&gt;Burballa, Carla&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Crespo%2C+Marta%22&quot;&gt;Crespo, Marta&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Redondo-Pach&#243;n%2C+Dolores%22&quot;&gt;Redondo-Pach&#243;n, Dolores&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22P&#233;rez-S&#225;ez%2C+Mar&#237;a+Jos&#233;%22&quot;&gt;P&#233;rez-S&#225;ez, Mar&#237;a Jos&#233;&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Arias-Cabrales%2C+Carlos%22&quot;&gt;Arias-Cabrales, Carlos&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mir%2C+Marisa%22&quot;&gt;Mir, Marisa&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Franc&#233;s%2C+Albert%22&quot;&gt;Franc&#233;s, Albert&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fumad&#243;b%2C+Llu&#237;s%22&quot;&gt;Fumad&#243;b, Llu&#237;s&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cecchini%2C+Llu&#237;s%22&quot;&gt;Cecchini, Llu&#237;s&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pascual%2C+Julio%22&quot;&gt;Pascual, Julio&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Nefrologia%22&quot;&gt;Nefrologia&lt;/searchLink&gt;. 2018, Vol. 38 Issue 5, p528-534. 7p.
– Name: Abstract
  Label: Abstract (English)
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  Data: Introduction: Kidney transplant donors lose 50% of their renal mass after nephrectomy. The remaining kidney compensates for this loss and it is estimated that 70% of the baseline renal function prior to donation is recovered. Factors associated with post-donation renal compensation are not well understood. Methods: Retrospective study of 66 consecutive kidney donors (mean age 48.8 years, 74.2% women). We analysed the potential factors associated with the compensatory mechanisms of the remaining kidney by comparing donors according to their renal compensation rate (RCR) (Group A, infra-compensation [&lt; 70%]; Group B, normal compensation [&gt; 70%]). Results: We compared Group A (n = 38) and group B (n = 28). Predictors for RCR &gt; 70% were higher baseline creatinine (A vs B: 0.73 &#177; 0.14 vs 0.82 &#177; 0.11; P = .03) and a lower baseline glomerular filtration rate (GFR), estimated both by MDRD-4 (A vs B: 97.7 &#177; 18.8 vs 78.6 &#177; 9.6 ml/min; P &lt; .001) and CKD-EPI (A vs B: 101.7 &#177; 15 vs. 88.3&#177;11.7 ml/min; P ≤ .001). Age, gender, smoking, hypertension and GFR measured by Tc-DTPA did not show any correlation with the RCR. The multivariate analysis confirmed baseline estimated glomerular filtration rate (eGFR) to be a predictor of compensation: the higher the baseline eGFR, the lower the likelihood of &gt; 70% compensation (MDRD-4, OR = 0.94 [95% CI 0.8--0.9], P = .01). The compensation rate decreased by 0.4% (P &lt; .001) and 0.3% (P = .006) for every ml/min increase in baseline eGFR estimated by MDRD-4 and CKD-EPI, respectively. Conclusions: One year after living donor nephrectomy, the remaining kidney partially compensates baseline renal function. In our experience, baseline eGFR is inversely proportional to the one-year renal compensation rate. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Introducci&#243;n: Los donantes renales pierden la mitad de su masa renal tras la nefrectom&#237;a. Se estima que el ri&#241;&#243;n remanente compensa id&#243;neamente un 70% de la funci&#243;n renal previa a la donaci&#243;n. Los factores asociados con el grado de compensaci&#243;n posdonaci&#243;n no est&#225;n bien establecidos. M&#233;todos: An&#225;lisis retrospectivo de 66 donantes renales consecutivos. Edad media 48,8 a&#241;os; 74,2% mujeres. Se estudiaron los potenciales factores asociados con la compensaci&#243;n del ri&#241;&#243;n remanente comparando donantes seg&#250;n su tasa de compensaci&#243;n renal (TCR) (grupo A, infra-compensaci&#243;n [&lt; 70%]; grupo B compensaci&#243;n normal [&gt; 70%]). Resultados: Comparamos los grupos A (n = 38) y B (n = 28). Los factores predictores de una TCR &gt; 70% fueron una mayor creatinina basal (A vs. B 0,73 &#177; 0,14 vs. 0,82 &#177; 0,11; p = 0,03) y menor filtrado glomerular (FG), tanto estimado mediante MDRD-4 (A vs. B 97,7 &#177; 18,8 vs. 78,6 &#177; 9,6 ml/min; p &lt; 0,001) como por CKD-EPI (A vs. B 101,7 &#177; 15 vs. 88,3 &#177; 11,7 ml/min; p ≤ 0,001). La edad, el sexo, el tabaquismo, la hipertensi&#243;n o el FG medido con Tcm-DTPA no mostraron asociaci&#243;n con la TCR. El an&#225;lisis multivariante confirm&#243; el FGe como predictor de compensaci&#243;n: a mayor FG basal menor probabilidad de compensar &gt; 70% (MDRD-4, odds ratio [OR] = 0,94 [IC 95%: 0,8-0,9], p = 0,01). La tasa de compensaci&#243;n era 0,4% (p &lt; 0,001) y 0,3% (p = 0,006), menor por cada ml/min de FG basal m&#225;s, por MDRD-4 y CKD-EPI respectivamente. Conclusiones: Un a&#241;o despu&#233;s de la donaci&#243;n renal el ri&#241;&#243;n remanente compensa parcialmente la funci&#243;n renal basal. En nuestra experiencia el FGe basal se asocia de forma inversamente proporcional a la tasa de compensaci&#243;n renal al a&#241;o. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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