A Comparative Study of Ketofol and Thiopental Sodium in Patients undergoing Dilation and Curettage by General Anesthesia.

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Bibliographic Details
Title:	A Comparative Study of Ketofol and Thiopental Sodium in Patients undergoing Dilation and Curettage by General Anesthesia.
Alternate Title:	Un estudio comparativo de Ketofol y sodio tiopental en pacientes sometidos a dilatación y curetaje por anestesia general.
Authors:	Yousefian, Mahzad¹, Farzipour, Shahla² Hasty6482@yahoo.com, Noroozi, Vadood³, Salmanfar, Tayebe
Source:	Revista Latinoamericana de Hipertensión. 2018, Vol. 13 Issue 6, p515-519. 5p.
Subjects:	GENERAL anesthesia, DILATATION & curettage, CESAREAN section, QUALITY of life, RANDOMIZED controlled trials
Abstract (English):	Considering that the combined drug, Ketofol has been used and its efficacy observed in patients, we have aimed to compare the effects of ketofol and thiopental sodium on patients who are undergoing dilatation and curettage. This study was conducted as a randomized controlled clinical trial. In this study, 150 patients undergoing dilatation and curettage after classification were randomly selected and enrolled. The first group received ketofol, while thiopental sodium was administered to the second group. Any change in hemodynamics or respiratory distress, including the occurrence of apnea or hypotension, desaturation and the need for respiratory support were recorded in both groups. Finally, after the completion of the surgery and transfer to the recovery room, the recovery rate of each group was recorded, and once they were conscious and alert, were questioned about their satisfaction. All of the patient information was entered into the SPSS v18 software, and the data were analyzed. This study was conducted on 150 patients undergoing curettage; the mean ages in the first and second groups were 31.82 ± 9.18 and 33.64 ± 11.39 years, respectively. Ninety two percent of patients in the ketofol group and 100% of the patients in the thiopental sodium group experienced apnea and needed respiratory support. About 25.3% of patients in the ketofol group and 44% of patients in the thiopental group required a re-dose of the drug for the anesthetic process. The duration of recovery in the ketofol group was lower than the other group. About 2.7% of the patients in the ketofol group and 12% of the patients in the thiopental group had hallucinations and delusions at the end of the operation Six patients in the thiopental group also had hiccups. The results of the present study showed that ketofol is a better drug than thiopental because of the duration of anesthesia, reducing the need for medication, the incidence of apnea, and the complications of anesthesia. [ABSTRACT FROM AUTHOR]
Abstract (Spanish):	Teniendo en cuenta que el fármaco combinado, Ketofol se ha utilizado y su eficacia se ha observado en pacientes, el objetivo fue comparar los efectos del ketofol y el sodio tiopental en pacientes que están en proceso de dilatación y legrado. Este estudio se realizó como un ensayo clínico aleatorizado controlado. En este estudio, 150 pacientes sometidos a dilatación y legrado después de la clasificación fueron seleccionados al azar y se inscribieron. El primer grupo recibió ketofol, mientras que el tiopental sódico se administró al segundo grupo. Cualquier cambio en la hemodinámica o dificultad respiratoria, incluida la aparición de apnea o hipotensión, la desaturación y la necesidad de asistencia respiratoria se registraron en ambos grupos. Finalmente, después de la finalización de la cirugía y el traslado a la sala de recuperación, se registró la tasa de recuperación de cada grupo, y una vez que estuvieron conscientes y alertas, se les preguntó acerca de su satisfacción. Toda la información del paciente se ingresó en el software SPSS v18 y los datos se analizaron. Este estudio se realizó en 150 pacientes sometidos a curetaje; Las edades medias en el primer y segundo grupo fueron 31.82 ± 9.18 y 33.64 ± 11.39 años, respectivamente. Noventa y dos por ciento de los pacientes en el grupo de ketofol y el 100% de los pacientes en el grupo de sodio tiopental experimentaron apnea y necesitaron asistencia respiratoria. Alrededor del 25,3% de los pacientes en el grupo de ketofol y el 44% de los pacientes en el grupo de tiopental requirieron una nueva dosis del fármaco para el proceso anestésico. La duración de la recuperación en el grupo de ketofol fue menor que en el otro grupo. Alrededor del 2,7% de los pacientes en el grupo de ketofol y el 12% de los pacientes en el grupo de tiopental tuvieron alucinaciones y delirios al final de la operación Seis pacientes en el grupo de tiopental también tuvieron hipo. Los resultados del presente estudio mostraron que el ketofol es un fármaco mejor que el tiopental debido a la duración de la anestesia, lo que reduce la necesidad de medicación, la incidencia de apnea y las complicaciones de la anestesia. [ABSTRACT FROM AUTHOR]
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Database:	MedicLatina

Description
Abstract:	Considering that the combined drug, Ketofol has been used and its efficacy observed in patients, we have aimed to compare the effects of ketofol and thiopental sodium on patients who are undergoing dilatation and curettage. This study was conducted as a randomized controlled clinical trial. In this study, 150 patients undergoing dilatation and curettage after classification were randomly selected and enrolled. The first group received ketofol, while thiopental sodium was administered to the second group. Any change in hemodynamics or respiratory distress, including the occurrence of apnea or hypotension, desaturation and the need for respiratory support were recorded in both groups. Finally, after the completion of the surgery and transfer to the recovery room, the recovery rate of each group was recorded, and once they were conscious and alert, were questioned about their satisfaction. All of the patient information was entered into the SPSS v18 software, and the data were analyzed. This study was conducted on 150 patients undergoing curettage; the mean ages in the first and second groups were 31.82 ± 9.18 and 33.64 ± 11.39 years, respectively. Ninety two percent of patients in the ketofol group and 100% of the patients in the thiopental sodium group experienced apnea and needed respiratory support. About 25.3% of patients in the ketofol group and 44% of patients in the thiopental group required a re-dose of the drug for the anesthetic process. The duration of recovery in the ketofol group was lower than the other group. About 2.7% of the patients in the ketofol group and 12% of the patients in the thiopental group had hallucinations and delusions at the end of the operation Six patients in the thiopental group also had hiccups. The results of the present study showed that ketofol is a better drug than thiopental because of the duration of anesthesia, reducing the need for medication, the incidence of apnea, and the complications of anesthesia. [ABSTRACT FROM AUTHOR]
ISSN:	18564550