ASSOCIATION BETWEEN BONE MARROW EDEMA AND STRUCTURAL PROGRESSION IN THE SAME QUADRANT IN AXIAL SPONDYLOARTHRITIS - 5-YEAR DATA FROM THE DESIR COHORT.
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| Title: | ASSOCIATION BETWEEN BONE MARROW EDEMA AND STRUCTURAL PROGRESSION IN THE SAME QUADRANT IN AXIAL SPONDYLOARTHRITIS - 5-YEAR DATA FROM THE DESIR COHORT. |
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| Authors: | Manica, Santiago Andres Rodrigues1,2, Sepriano, Alexandre2,3, Ramiro, Sofia2,3,4, Landewé, Robert5, Claudepierre, Pascal6, Moltó, Anna7, M., Dougados7, van Lunteren, Miranda3, van der Heijde, Désirée3 |
| Source: | Acta Reumatológica Portuguesa. 2019 Special Issue, p26-27. 2p. |
| Subjects: | EDEMA, BONE marrow diseases, DISEASE progression, SPONDYLOARTHROPATHIES, MEDICAL radiography complications, INFLAMMATION |
| Abstract: | Background: The overall presence of inflammation in the MRI-SIJ is associated with overall 5-year radiographic damage in patients with axSpA1. But we do not know if a bone marrow edema (BME) lesion leads to a structural lesion at the same place (i.e. in the same quadrant). Objective: To investigate the association between BME and structural progression in the same quadrant of the SIJ, over time. Methods: Patients from the DESIR cohort (early axSpA according to the rheumatologist) with =2 consecutive MRI-SIJ (out of baseline, 2 and 5 years), were included. Each image was independently scored by 3 trained central readers blinded to chronological order. BME was considered present in a time point if detected in =1/6 slices in each of the 8 quadrants. The prevalence of BME (yes/no) and structural lesions (sclerosis, erosions, fatty lesions and ankylosis; all yes/no) defined, per quadrant, by the agreement of =2 out of 3 readers, was described at BL and at 5 years. The longitudinal association between BME and each of the structural lesions in the same quadrant was tested in timelagged multilevel Generalized Estimating Equation (GEE) models with autoregression, taking individual reader data into account, and adjusting for clinical va - riables selected a priori on clinical grounds (age, gender, disease activity and treatment). Results: In total, 197 patients were included (age 34 (SD 9) years, 48% male and 61% HLA-B27 positive). While BME and fatty lesions were evenly distributed across quadrants, erosions and sclerosis occurred preferably in the iliac side (i.e. Q1 and Q4) (Table 1). The prevalence of BME decreased over time (baseline range: 11%-16%; 5-year range: 7%-14%), while erosions (baseline range: 2%-23%; 5-year range: 3%-28%) and especially fatty lesions (baseline range: 4%-14%; 5-year range: 9%-21%) increased. Ankylosis and sclerosis were rare in this early axSpA cohort. In the multivariable models, BME was longitudinally associated with sclerosis (OR:1.7 (95% CI: 1.0;3.2)), erosions (2.0 (1.5;2.5)) and fatty lesions (1.7 (1.1;2.5)). The possible association with ankylosis could not be tested due to too low number of lesions. Conclusion: We here demonstrate that in early axSpA- patients inflammation in one SIJ quadrant leads to structural damage in the same quadrant. This finding reinforces the pathophysiological implications of inflammation in axSpA. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Reumatológica Portuguesa is the property of Sociedade Portuguesa de Reumatologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: ASSOCIATION BETWEEN BONE MARROW EDEMA AND STRUCTURAL PROGRESSION IN THE SAME QUADRANT IN AXIAL SPONDYLOARTHRITIS - 5-YEAR DATA FROM THE DESIR COHORT. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Manica%2C+Santiago+Andres+Rodrigues%22">Manica, Santiago Andres Rodrigues</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Sepriano%2C+Alexandre%22">Sepriano, Alexandre</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Ramiro%2C+Sofia%22">Ramiro, Sofia</searchLink><relatesTo>2,3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Landewé%2C+Robert%22">Landewé, Robert</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Claudepierre%2C+Pascal%22">Claudepierre, Pascal</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Moltó%2C+Anna%22">Moltó, Anna</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22M%2E%2C+Dougados%22">M., Dougados</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22van+Lunteren%2C+Miranda%22">van Lunteren, Miranda</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22van+der+Heijde%2C+Désirée%22">van der Heijde, Désirée</searchLink><relatesTo>3</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Reumatológica+Portuguesa%22">Acta Reumatológica Portuguesa</searchLink>. 2019 Special Issue, p26-27. 2p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22EDEMA%22">EDEMA</searchLink><br /><searchLink fieldCode="DE" term="%22BONE+marrow+diseases%22">BONE marrow diseases</searchLink><br /><searchLink fieldCode="DE" term="%22DISEASE+progression%22">DISEASE progression</searchLink><br /><searchLink fieldCode="DE" term="%22SPONDYLOARTHROPATHIES%22">SPONDYLOARTHROPATHIES</searchLink><br /><searchLink fieldCode="DE" term="%22MEDICAL+radiography+complications%22">MEDICAL radiography complications</searchLink><br /><searchLink fieldCode="DE" term="%22INFLAMMATION%22">INFLAMMATION</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: The overall presence of inflammation in the MRI-SIJ is associated with overall 5-year radiographic damage in patients with axSpA1. But we do not know if a bone marrow edema (BME) lesion leads to a structural lesion at the same place (i.e. in the same quadrant). Objective: To investigate the association between BME and structural progression in the same quadrant of the SIJ, over time. Methods: Patients from the DESIR cohort (early axSpA according to the rheumatologist) with =2 consecutive MRI-SIJ (out of baseline, 2 and 5 years), were included. Each image was independently scored by 3 trained central readers blinded to chronological order. BME was considered present in a time point if detected in =1/6 slices in each of the 8 quadrants. The prevalence of BME (yes/no) and structural lesions (sclerosis, erosions, fatty lesions and ankylosis; all yes/no) defined, per quadrant, by the agreement of =2 out of 3 readers, was described at BL and at 5 years. The longitudinal association between BME and each of the structural lesions in the same quadrant was tested in timelagged multilevel Generalized Estimating Equation (GEE) models with autoregression, taking individual reader data into account, and adjusting for clinical va - riables selected a priori on clinical grounds (age, gender, disease activity and treatment). Results: In total, 197 patients were included (age 34 (SD 9) years, 48% male and 61% HLA-B27 positive). While BME and fatty lesions were evenly distributed across quadrants, erosions and sclerosis occurred preferably in the iliac side (i.e. Q1 and Q4) (Table 1). The prevalence of BME decreased over time (baseline range: 11%-16%; 5-year range: 7%-14%), while erosions (baseline range: 2%-23%; 5-year range: 3%-28%) and especially fatty lesions (baseline range: 4%-14%; 5-year range: 9%-21%) increased. Ankylosis and sclerosis were rare in this early axSpA cohort. In the multivariable models, BME was longitudinally associated with sclerosis (OR:1.7 (95% CI: 1.0;3.2)), erosions (2.0 (1.5;2.5)) and fatty lesions (1.7 (1.1;2.5)). The possible association with ankylosis could not be tested due to too low number of lesions. Conclusion: We here demonstrate that in early axSpA- patients inflammation in one SIJ quadrant leads to structural damage in the same quadrant. This finding reinforces the pathophysiological implications of inflammation in axSpA. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Reumatológica Portuguesa is the property of Sociedade Portuguesa de Reumatologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 2 StartPage: 26 Subjects: – SubjectFull: EDEMA Type: general – SubjectFull: BONE marrow diseases Type: general – SubjectFull: DISEASE progression Type: general – SubjectFull: SPONDYLOARTHROPATHIES Type: general – SubjectFull: MEDICAL radiography complications Type: general – SubjectFull: INFLAMMATION Type: general Titles: – TitleFull: ASSOCIATION BETWEEN BONE MARROW EDEMA AND STRUCTURAL PROGRESSION IN THE SAME QUADRANT IN AXIAL SPONDYLOARTHRITIS - 5-YEAR DATA FROM THE DESIR COHORT. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Manica, Santiago Andres Rodrigues – PersonEntity: Name: NameFull: Sepriano, Alexandre – PersonEntity: Name: NameFull: Ramiro, Sofia – PersonEntity: Name: NameFull: Landewé, Robert – PersonEntity: Name: NameFull: Claudepierre, Pascal – PersonEntity: Name: NameFull: Moltó, Anna – PersonEntity: Name: NameFull: M., Dougados – PersonEntity: Name: NameFull: van Lunteren, Miranda – PersonEntity: Name: NameFull: van der Heijde, Désirée IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 04 Text: 2019 Special Issue Type: published Y: 2019 Identifiers: – Type: issn-print Value: 0303464X Titles: – TitleFull: Acta Reumatológica Portuguesa Type: main |
| ResultId | 1 |
