Estudio histopatológico en tejido cardiaco de roedores infectados con Trypanosoma cruzi, capturados en barrios suburbanos, Mérida, México.
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| Title: | Estudio histopatológico en tejido cardiaco de roedores infectados con Trypanosoma cruzi, capturados en barrios suburbanos, Mérida, México. |
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| Alternate Title: | Histopathological study in cardiac tissue of rodents infected with Trypanosoma cruzi, captured in suburbs, Merida, Mexico. |
| Authors: | Ucan-Euan, Fernando1, Hernández-Betancourt, Silvia1, Arjona-Torres, Madeleine2, Panti-May, Alonso3, Torres-Castro, Marco4 antonio.torres@correo.uady.mx |
| Source: | Biomédica: Revista del Instituto Nacional de Salud. 2019 Supplement, Vol. 39, p1-31. 31p. |
| Abstract (English): | Introduction: Trypanosoma cruzi is the causal agent of the American Trypanosomiasis, an endemic disease in Mexico. The commensal rodents Mus musculus and Rattus rattus are reservoirs of this parasite, which invades cardiac fibers and develops parasite nests and various lesions. Histopathological studies in naturally infected rodents are scarce. Objective: To describe the types and frequencies of microscopic lesions in cardiac tissue of M. musculus and R. rattus infected with T. cruzi, captured in Merida, Mexico. Materials and methods: The rodents were captured in suburban environments of Merida. Cardiac tissue was extracted and processed by the paraffin inclusion technique, hematoxylin and eosin-stained. The observation was made with a conventional microscope and all the lesions and the affection degree were identified. Results: Eight tissues of M. musculus and seven of R. rattus were studied. Parasite nests were found in 46,6% (7/15); specifically: 37,5% (3/8) in M. musculus and 57,1% (4/7) in R. rattus. The inflammatory infiltrate was the most frequent lesion (100%). Other lesions were: degeneration of cardiac fibers (53,3%, 8/15), congestion of blood vessels (40%, 6/15) and necrosis (33,3%, 5/15). Discussion: The observed lesions are described in experimental animal models and in humans with American Trypanosomiasis. The inflammatory infiltrate is identified as the most significant lesion in humans and reservoirs in the chronic stage of the disease. Conclusion: The described lesions are associated with T. cruzi infection, which confirms that the rodents studied are reservoirs of this parasite. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Introducción. Trypanosoma cruzi es agente causal de la tripanosomiasis americana, enfermedad endémica en México. Los roedores Mus musculus y Rattus rattus son reservorios del parásito, el cual invade fibras cardiacas y desarrolla nidos parasitarios y diversas lesiones. Los estudios histopatológicos en roedores naturalmente infectados son escasos. Objetivo. Describir tipos y frecuencias de lesiones microscópicas en tejido cardiaco de M. musculus y R. rattus infectados con T. cruzi, capturados en Mérida, México. Materiales y métodos. Los roedores se capturaron en barrios suburbanos de Mérida. Se extrajo tejido cardiaco y se procesó por la técnica de inclusión en parafina, teñidos con hematoxilina y eosina. La observación se realizó con un microscópico convencional y se identificaron todas las lesiones y su grado de afección. Resultados. Se trabajaron ocho tejidos de M. musculus y siete de R. rattus. Se encontraron nidos parasitarios en un 46,6% (7/15); específicamente: 37,5% (3/8) en M. musculus y 57,1% (4/7) en R. rattus. Los infiltrados inflamatorios fueron la lesión más frecuente (100%). Otras lesiones fueron: degeneración de fibras cardiacas (53,3%, 8/15), congestión de vasos sanguíneos (40%, 6/15) y necrosis (33,3%, 5/15). Discusión. Las lesiones identificadas están descritas en modelos animales experimentales y en humanos con Tripanosomiasis Americana. Los infiltrados inflamatorios están descritos como la lesión más significativa en humanos y reservorios en la etapa crónica de la enfermedad. Conclusión. Las lesiones identificadas están asociadas con la infección con T. cruzi, lo cual confirma que los roedores estudiados son reservorios de este parásito. [ABSTRACT FROM AUTHOR] |
| Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: Estudio histopatológico en tejido cardiaco de roedores infectados con Trypanosoma cruzi, capturados en barrios suburbanos, Mérida, México. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Histopathological study in cardiac tissue of rodents infected with Trypanosoma cruzi, captured in suburbs, Merida, Mexico. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ucan-Euan%2C+Fernando%22">Ucan-Euan, Fernando</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hernández-Betancourt%2C+Silvia%22">Hernández-Betancourt, Silvia</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Arjona-Torres%2C+Madeleine%22">Arjona-Torres, Madeleine</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Panti-May%2C+Alonso%22">Panti-May, Alonso</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Torres-Castro%2C+Marco%22">Torres-Castro, Marco</searchLink><relatesTo>4</relatesTo><i> antonio.torres@correo.uady.mx</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biomédica%3A+Revista+del+Instituto+Nacional+de+Salud%22">Biomédica: Revista del Instituto Nacional de Salud</searchLink>. 2019 Supplement, Vol. 39, p1-31. 31p. – Name: Abstract Label: Abstract (English) Group: Ab Data: Introduction: Trypanosoma cruzi is the causal agent of the American Trypanosomiasis, an endemic disease in Mexico. The commensal rodents Mus musculus and Rattus rattus are reservoirs of this parasite, which invades cardiac fibers and develops parasite nests and various lesions. Histopathological studies in naturally infected rodents are scarce. Objective: To describe the types and frequencies of microscopic lesions in cardiac tissue of M. musculus and R. rattus infected with T. cruzi, captured in Merida, Mexico. Materials and methods: The rodents were captured in suburban environments of Merida. Cardiac tissue was extracted and processed by the paraffin inclusion technique, hematoxylin and eosin-stained. The observation was made with a conventional microscope and all the lesions and the affection degree were identified. Results: Eight tissues of M. musculus and seven of R. rattus were studied. Parasite nests were found in 46,6% (7/15); specifically: 37,5% (3/8) in M. musculus and 57,1% (4/7) in R. rattus. The inflammatory infiltrate was the most frequent lesion (100%). Other lesions were: degeneration of cardiac fibers (53,3%, 8/15), congestion of blood vessels (40%, 6/15) and necrosis (33,3%, 5/15). Discussion: The observed lesions are described in experimental animal models and in humans with American Trypanosomiasis. The inflammatory infiltrate is identified as the most significant lesion in humans and reservoirs in the chronic stage of the disease. Conclusion: The described lesions are associated with T. cruzi infection, which confirms that the rodents studied are reservoirs of this parasite. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Introducción. Trypanosoma cruzi es agente causal de la tripanosomiasis americana, enfermedad endémica en México. Los roedores Mus musculus y Rattus rattus son reservorios del parásito, el cual invade fibras cardiacas y desarrolla nidos parasitarios y diversas lesiones. Los estudios histopatológicos en roedores naturalmente infectados son escasos. Objetivo. Describir tipos y frecuencias de lesiones microscópicas en tejido cardiaco de M. musculus y R. rattus infectados con T. cruzi, capturados en Mérida, México. Materiales y métodos. Los roedores se capturaron en barrios suburbanos de Mérida. Se extrajo tejido cardiaco y se procesó por la técnica de inclusión en parafina, teñidos con hematoxilina y eosina. La observación se realizó con un microscópico convencional y se identificaron todas las lesiones y su grado de afección. Resultados. Se trabajaron ocho tejidos de M. musculus y siete de R. rattus. Se encontraron nidos parasitarios en un 46,6% (7/15); específicamente: 37,5% (3/8) en M. musculus y 57,1% (4/7) en R. rattus. Los infiltrados inflamatorios fueron la lesión más frecuente (100%). Otras lesiones fueron: degeneración de fibras cardiacas (53,3%, 8/15), congestión de vasos sanguíneos (40%, 6/15) y necrosis (33,3%, 5/15). Discusión. Las lesiones identificadas están descritas en modelos animales experimentales y en humanos con Tripanosomiasis Americana. Los infiltrados inflamatorios están descritos como la lesión más significativa en humanos y reservorios en la etapa crónica de la enfermedad. Conclusión. Las lesiones identificadas están asociadas con la infección con T. cruzi, lo cual confirma que los roedores estudiados son reservorios de este parásito. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 31 StartPage: 1 Titles: – TitleFull: Estudio histopatológico en tejido cardiaco de roedores infectados con Trypanosoma cruzi, capturados en barrios suburbanos, Mérida, México. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ucan-Euan, Fernando – PersonEntity: Name: NameFull: Hernández-Betancourt, Silvia – PersonEntity: Name: NameFull: Arjona-Torres, Madeleine – PersonEntity: Name: NameFull: Panti-May, Alonso – PersonEntity: Name: NameFull: Torres-Castro, Marco IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 08 Text: 2019 Supplement Type: published Y: 2019 Identifiers: – Type: issn-print Value: 01204157 Numbering: – Type: volume Value: 39 Titles: – TitleFull: Biomédica: Revista del Instituto Nacional de Salud Type: main |
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