Sarcopenia: aspectos clínico-terapéuticos.
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| Title: | Sarcopenia: aspectos clínico-terapéuticos. |
|---|---|
| Alternate Title: | Sarcopenia: clinical-therapeutical aspects. |
| Authors: | Crushirira Reina, Orlando Rosendo1 drorlandosk8@hotmail.com, Bastidas Rueda, Gary David2, Yépez Guachamín, Priscila Estefania3, Vilatuña Llumiquinga, Katherine Alejandra4, Agualongo Cubi, Paúl Alex5, Lema Sanango, Gabriela Marisol1, Llerena Freire, Luis Francisco6, Patricio Javier, Pérez Miranda7, Montero Ortiz, Favio Alberto1 |
| Source: | Archivos Venezolanos de Farmacología y Terapéutica. 2019, Vol. 38 Issue 1, p72-76. 5p. |
| Abstract (English): | Aging is a series of morphological, functional and psychological changes that cause the time on living beings, one of the physiological aspects that major change suffers the older patient is body mass variation. Among the various clinical syndrome related to body composition, sarcopenia is characterized by the gradual and generalized loss of skeletal muscle mass and strength, whose description goes back to approximately the 70's. The pathological mechanisms involved emphasize the degree of exercise, nutritional status, hormonal changes, increase in age-related cytokines that act on mechanisms such as oxidative stress, muscle protein turnover, loss of alpha motor neurons, apoptosis, among others; which will depend on the primary or secondary etiology of sarcopenia. For its diagnosis, 3 criteria have been used in a conventional manner that include mass, strength and muscular performance, whose measurement techniques vary according to the purpose for which they are used (research or clinical practice) and whose combination of criteria also varies according to the organization to be analyzed, this has led to important epidemiological variations worldwide. The therapeutic approach is based on improving the quality of life of the person through the combination of adequate nutrition, a regular exercise program and there is poor benefit evidence generated by protein nutritional supplements and drugs, currently in preliminary trials, as inhibitors of the angiotensinconverting enzyme, statins, vitamin D and hormonal agents. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | El envejecimiento consiste en una serie de modificaciones morfológicas, funcionales y psicológicas que origina el paso del tiempo sobre los seres vivos, uno de los aspectos fisiológicos que mayor cambio sufre el paciente adulto mayor es la variación de la masa corporal. Entre los diversos síndrome clínicos relacionados con la composición corporal, la sarcopenia se caracteriza por la pérdida gradual y generalizada de la masa y fuerza muscular esquelética, cuya descripción se remonta aproximadamente a la década de los 70. Los mecanismos fisiopatológicos involucrados destacan el grado de ejercicio físico, el estado nutricional, cambios hormonales, aumento de citoquinas relacionados con la edad que actúan sobre mecanismos como el estrés oxidativo, recambio de las proteínas musculares, pérdida de motoneuronas alfa, apoptosis, entre otros; los cuales dependerán de la etiología primaria o secundaria de la sarcopenia. Para su diagnóstico se han utilizado de manera convencional 3 criterios que abarcan masa, fuerza y rendimiento muscular, cuyas técnicas de medición varían de acuerdo al fin para el cual se empleen (investigación o práctica clínica) y cuya combinación de criterios también varía según la organización que se analice, esto ha llevado a importante variaciones epidemiológicas a nivel mundial. El abordaje terapéutico se basa en mejorar la calidad de vida de la persona mediante la combinación de una nutrición adecuada, un programa de ejercicio regular y existe pocas evidencias del beneficio que generan los suplementos nutricionales proteicos y fármacos, actualmente en ensayos preliminares, como inhibidores de la enzima convertidora de angiotensina, estatinas, vitamina D y agentes hormonales. [ABSTRACT FROM AUTHOR] |
| Copyright of Archivos Venezolanos de Farmacología y Terapéutica is the property of Archivos Venezolanos de Farmacologia y Terapeutica and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 137697614 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Sarcopenia: aspectos clínico-terapéuticos. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Sarcopenia: clinical-therapeutical aspects. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Crushirira+Reina%2C+Orlando+Rosendo%22">Crushirira Reina, Orlando Rosendo</searchLink><relatesTo>1</relatesTo><i> drorlandosk8@hotmail.com</i><br /><searchLink fieldCode="AR" term="%22Bastidas+Rueda%2C+Gary+David%22">Bastidas Rueda, Gary David</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Yépez+Guachamín%2C+Priscila+Estefania%22">Yépez Guachamín, Priscila Estefania</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Vilatuña+Llumiquinga%2C+Katherine+Alejandra%22">Vilatuña Llumiquinga, Katherine Alejandra</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Agualongo+Cubi%2C+Paúl+Alex%22">Agualongo Cubi, Paúl Alex</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Lema+Sanango%2C+Gabriela+Marisol%22">Lema Sanango, Gabriela Marisol</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Llerena+Freire%2C+Luis+Francisco%22">Llerena Freire, Luis Francisco</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Patricio+Javier%2C+Pérez+Miranda%22">Patricio Javier, Pérez Miranda</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Montero+Ortiz%2C+Favio+Alberto%22">Montero Ortiz, Favio Alberto</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Archivos+Venezolanos+de+Farmacología+y+Terapéutica%22">Archivos Venezolanos de Farmacología y Terapéutica</searchLink>. 2019, Vol. 38 Issue 1, p72-76. 5p. – Name: Abstract Label: Abstract (English) Group: Ab Data: Aging is a series of morphological, functional and psychological changes that cause the time on living beings, one of the physiological aspects that major change suffers the older patient is body mass variation. Among the various clinical syndrome related to body composition, sarcopenia is characterized by the gradual and generalized loss of skeletal muscle mass and strength, whose description goes back to approximately the 70's. The pathological mechanisms involved emphasize the degree of exercise, nutritional status, hormonal changes, increase in age-related cytokines that act on mechanisms such as oxidative stress, muscle protein turnover, loss of alpha motor neurons, apoptosis, among others; which will depend on the primary or secondary etiology of sarcopenia. For its diagnosis, 3 criteria have been used in a conventional manner that include mass, strength and muscular performance, whose measurement techniques vary according to the purpose for which they are used (research or clinical practice) and whose combination of criteria also varies according to the organization to be analyzed, this has led to important epidemiological variations worldwide. The therapeutic approach is based on improving the quality of life of the person through the combination of adequate nutrition, a regular exercise program and there is poor benefit evidence generated by protein nutritional supplements and drugs, currently in preliminary trials, as inhibitors of the angiotensinconverting enzyme, statins, vitamin D and hormonal agents. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: El envejecimiento consiste en una serie de modificaciones morfológicas, funcionales y psicológicas que origina el paso del tiempo sobre los seres vivos, uno de los aspectos fisiológicos que mayor cambio sufre el paciente adulto mayor es la variación de la masa corporal. Entre los diversos síndrome clínicos relacionados con la composición corporal, la sarcopenia se caracteriza por la pérdida gradual y generalizada de la masa y fuerza muscular esquelética, cuya descripción se remonta aproximadamente a la década de los 70. Los mecanismos fisiopatológicos involucrados destacan el grado de ejercicio físico, el estado nutricional, cambios hormonales, aumento de citoquinas relacionados con la edad que actúan sobre mecanismos como el estrés oxidativo, recambio de las proteínas musculares, pérdida de motoneuronas alfa, apoptosis, entre otros; los cuales dependerán de la etiología primaria o secundaria de la sarcopenia. Para su diagnóstico se han utilizado de manera convencional 3 criterios que abarcan masa, fuerza y rendimiento muscular, cuyas técnicas de medición varían de acuerdo al fin para el cual se empleen (investigación o práctica clínica) y cuya combinación de criterios también varía según la organización que se analice, esto ha llevado a importante variaciones epidemiológicas a nivel mundial. El abordaje terapéutico se basa en mejorar la calidad de vida de la persona mediante la combinación de una nutrición adecuada, un programa de ejercicio regular y existe pocas evidencias del beneficio que generan los suplementos nutricionales proteicos y fármacos, actualmente en ensayos preliminares, como inhibidores de la enzima convertidora de angiotensina, estatinas, vitamina D y agentes hormonales. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Archivos Venezolanos de Farmacología y Terapéutica is the property of Archivos Venezolanos de Farmacologia y Terapeutica and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 5 StartPage: 72 Titles: – TitleFull: Sarcopenia: aspectos clínico-terapéuticos. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Crushirira Reina, Orlando Rosendo – PersonEntity: Name: NameFull: Bastidas Rueda, Gary David – PersonEntity: Name: NameFull: Yépez Guachamín, Priscila Estefania – PersonEntity: Name: NameFull: Vilatuña Llumiquinga, Katherine Alejandra – PersonEntity: Name: NameFull: Agualongo Cubi, Paúl Alex – PersonEntity: Name: NameFull: Lema Sanango, Gabriela Marisol – PersonEntity: Name: NameFull: Llerena Freire, Luis Francisco – PersonEntity: Name: NameFull: Patricio Javier, Pérez Miranda – PersonEntity: Name: NameFull: Montero Ortiz, Favio Alberto IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2019 Type: published Y: 2019 Identifiers: – Type: issn-print Value: 07980264 Numbering: – Type: volume Value: 38 – Type: issue Value: 1 Titles: – TitleFull: Archivos Venezolanos de Farmacología y Terapéutica Type: main |
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