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Expresión de marcadores inmunohistoquímicos en patología quirúrgica del cáncer de mama en el norte de México.

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Title: Expresión de marcadores inmunohistoquímicos en patología quirúrgica del cáncer de mama en el norte de México.
Alternate Title: Characterization of immunohistochemical markers in surgical pathology of breast cancer in the north of Mexico.
Authors: Edith Pastén-Zapata, Adriana1, González-Habib, Roberto2, Alberto Hernández-Salazar, Jorge3, Cecilia Gómez-Torres, Perla1
Source: Ginecología y Obstetricia de México. nov2019, Vol. 87 Issue 11, p734-739. 6p.
Subjects: IMMUNOHISTOCHEMISTRY, SURGICAL pathology, BREAST cancer, CEREBRAL dominance, PREGNANCY
Abstract (English): OBJECTIVE: To describe the expression of immunohistochemical markers in breast cancer surgical pieces in women in a hospital in the north of Mexico. MATERIALS AND METHODS: A descriptive and cross-sectional study; we inspect clinical records of women diagnosed with breast cancer who underwent surgery and immunohistochemical study at a private hospital in Monterrey, from 2013 to 2018. Inclusion criteria: Women of any age; with a diagnosis of breast cancer; surgically operated at the private hospital; with complete immunohistochemical markers. Exclusion criteria: men with breast cancer; incomplete immunohistochemical study; incomplete clinical history. The variables studied we included age, laterality, histological type, molecular subtype, histological grade, clinical stage, number of gestations and body mass index. In the statistical analysis, for the qualitative variables the c2 test was used, to correlate quantitative variables the Spearman's Rho coefficient test was used and to see prediction and behavior of qualitative polytomous variables, multinominal logistic regression was performed. RESULTS: 136 files were analyzed; the average age at diagnosis of breast cancer was 54 years (± 25 and 87); In 12 patients the diagnosis was established before the age of 40. The most prevalent histological type was infiltrating ductal adenocarcinoma (94.9%), the most frequent molecular subtype was luminal A (66.9%). The molecular subtypes were correlated with stage IA, except HER-2 which did so with IIA. CONCLUSION: The luminal tumor type A was the most frequent and with the best prognosis and luminal B had an intermediate survival. A high percentage of patients were positive for estrogen and progesterone receptors and lower for HER2/neu. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): OBJETIVO: Describir la expresión de marcadores inmunohistoquímicos en las piezas quirúrgicas de cáncer de mama de un grupo de mujeres atendidas en un hospital del norte de México. MATERIALES Y MÉTODOS: Estudio descriptivo y transversal que analiza los expedientes de pacientes con diagnóstico de cáncer de mama e intervenidas quirúrgicamente, con estudio inmunohistoquímico en un hospital privado de Monterrey (2013-2018). Criterios de inclusión: mujeres de cualquier edad, con diagnóstico de cáncer de mama, operadas en el hospital donde se practicó la prueba de inmunohistoquímica. Criterios de exclusión: historia clínica y estudio inmunohistoquímico incompletos. Variables de estudio: edad, lateralidad, tipo y grado histológico, subtipo molecular, estadio clínico, embarazos e índice de masa corporal. Para el análisis de las variables cualitativas se utilizó c2, coeficiente de Rho de Spearman para correlacionar variables cuantitativas y para predicción y comportamiento de variables cualitativas politómicas logística multinominal. RESULTADOS: Se analizaron 136 expedientes; la edad promedio al diagnóstico de cáncer de mama fue 54 años (± 25 y 87); en 12 pacientes el diagnóstico se estableció antes de los 40 años. El tipo histológico más prevalente fue el adenocarcinoma ductal infiltrante (94.9%), el subtipo molecular más frecuente fue el luminal A (66.9%). Los subtipos moleculares se correlacionaron con el estadio IA, excepto HER-2 que lo hizo con el IIA. CONCLUSIÓN: El tumor luminal tipo A fue el más frecuente y de mejor pronóstico y el luminal B tuvo una supervivencia intermedia. Un alto porcentaje de las pacientes tuvo positividad para receptores de estrógeno y de progesterona y menor para HER2/neu. [ABSTRACT FROM AUTHOR]
Copyright of Ginecología y Obstetricia de México is the property of Federacion Mexicana de Ginecologia y Obstetricia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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  Data: Expresión de marcadores inmunohistoquímicos en patología quirúrgica del cáncer de mama en el norte de México.
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  Data: Characterization of immunohistochemical markers in surgical pathology of breast cancer in the north of Mexico.
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  Data: <searchLink fieldCode="AR" term="%22Edith+Pastén-Zapata%2C+Adriana%22">Edith Pastén-Zapata, Adriana</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22González-Habib%2C+Roberto%22">González-Habib, Roberto</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Alberto+Hernández-Salazar%2C+Jorge%22">Alberto Hernández-Salazar, Jorge</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Cecilia+Gómez-Torres%2C+Perla%22">Cecilia Gómez-Torres, Perla</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Ginecología+y+Obstetricia+de+México%22">Ginecología y Obstetricia de México</searchLink>. nov2019, Vol. 87 Issue 11, p734-739. 6p.
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– Name: Abstract
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  Data: OBJECTIVE: To describe the expression of immunohistochemical markers in breast cancer surgical pieces in women in a hospital in the north of Mexico. MATERIALS AND METHODS: A descriptive and cross-sectional study; we inspect clinical records of women diagnosed with breast cancer who underwent surgery and immunohistochemical study at a private hospital in Monterrey, from 2013 to 2018. Inclusion criteria: Women of any age; with a diagnosis of breast cancer; surgically operated at the private hospital; with complete immunohistochemical markers. Exclusion criteria: men with breast cancer; incomplete immunohistochemical study; incomplete clinical history. The variables studied we included age, laterality, histological type, molecular subtype, histological grade, clinical stage, number of gestations and body mass index. In the statistical analysis, for the qualitative variables the c2 test was used, to correlate quantitative variables the Spearman's Rho coefficient test was used and to see prediction and behavior of qualitative polytomous variables, multinominal logistic regression was performed. RESULTS: 136 files were analyzed; the average age at diagnosis of breast cancer was 54 years (± 25 and 87); In 12 patients the diagnosis was established before the age of 40. The most prevalent histological type was infiltrating ductal adenocarcinoma (94.9%), the most frequent molecular subtype was luminal A (66.9%). The molecular subtypes were correlated with stage IA, except HER-2 which did so with IIA. CONCLUSION: The luminal tumor type A was the most frequent and with the best prognosis and luminal B had an intermediate survival. A high percentage of patients were positive for estrogen and progesterone receptors and lower for HER2/neu. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: OBJETIVO: Describir la expresión de marcadores inmunohistoquímicos en las piezas quirúrgicas de cáncer de mama de un grupo de mujeres atendidas en un hospital del norte de México. MATERIALES Y MÉTODOS: Estudio descriptivo y transversal que analiza los expedientes de pacientes con diagnóstico de cáncer de mama e intervenidas quirúrgicamente, con estudio inmunohistoquímico en un hospital privado de Monterrey (2013-2018). Criterios de inclusión: mujeres de cualquier edad, con diagnóstico de cáncer de mama, operadas en el hospital donde se practicó la prueba de inmunohistoquímica. Criterios de exclusión: historia clínica y estudio inmunohistoquímico incompletos. Variables de estudio: edad, lateralidad, tipo y grado histológico, subtipo molecular, estadio clínico, embarazos e índice de masa corporal. Para el análisis de las variables cualitativas se utilizó c2, coeficiente de Rho de Spearman para correlacionar variables cuantitativas y para predicción y comportamiento de variables cualitativas politómicas logística multinominal. RESULTADOS: Se analizaron 136 expedientes; la edad promedio al diagnóstico de cáncer de mama fue 54 años (± 25 y 87); en 12 pacientes el diagnóstico se estableció antes de los 40 años. El tipo histológico más prevalente fue el adenocarcinoma ductal infiltrante (94.9%), el subtipo molecular más frecuente fue el luminal A (66.9%). Los subtipos moleculares se correlacionaron con el estadio IA, excepto HER-2 que lo hizo con el IIA. CONCLUSIÓN: El tumor luminal tipo A fue el más frecuente y de mejor pronóstico y el luminal B tuvo una supervivencia intermedia. Un alto porcentaje de las pacientes tuvo positividad para receptores de estrógeno y de progesterona y menor para HER2/neu. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Ginecología y Obstetricia de México is the property of Federacion Mexicana de Ginecologia y Obstetricia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=139467320
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        Value: 10.24245/gom.v87i11.3013
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        Text: Spanish
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      – SubjectFull: IMMUNOHISTOCHEMISTRY
        Type: general
      – SubjectFull: SURGICAL pathology
        Type: general
      – SubjectFull: BREAST cancer
        Type: general
      – SubjectFull: CEREBRAL dominance
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      – SubjectFull: PREGNANCY
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            NameFull: González-Habib, Roberto
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            NameFull: Alberto Hernández-Salazar, Jorge
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            NameFull: Cecilia Gómez-Torres, Perla
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              Text: nov2019
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