Synapses and neural communication in neuropathological conditions.
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| Title: | Synapses and neural communication in neuropathological conditions. |
|---|---|
| Alternate Title: | Sinapsis y comunicación neuronal en afecciones neuropatológicas. |
| Authors: | Sánchez, Alejandro1 alejandroSG@uabc.edu.mx, Flores, Dora L.2,3, Leyva, Eugenio1, Castro, Carlos2 |
| Source: | Revista Mexicana de Neurociencia. May/Jun2020, Vol. 21 Issue 3, p111-121. 11p. |
| Subjects: | SYNAPSES, GAP junctions (Cell biology), TREATMENT of neurodegeneration, NEUROLOGICAL disorders, CELL communication |
| Abstract (English): | The central nervous system (CNS) is an extraordinary and complex communication network that receives voluminous amounts of information simultaneously but is vulnerable to disease and injury. This research emphasizes on the importance of gap junctions in neuropathological conditions and neurodegenerative diseases. Namely, we explore the degree of participation of chemical and electrical synapses within an updated panorama of integrative molecular techniques used for their study. The number of electrical and chemical synapses that coexist in the human brain is unknown, yet they are present in almost all types of cells. Frequently, electrical and chemical synapses are found separately, yet sometimes mixed electrical-chemical synapses are found coupled or together. Unfortunately, synaptic dysfunction has adverse effects on organs and vital structures. In this review, we discuss the most common diseases derived from synaptic dysfunction, as well as their occurrence in Mexico. Similarly, we discuss current treatments for diseases involving human connexins. Studies on the CNS are important to understand how this system works and explain current action mechanisms used as treatments of neuropathologies. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | El sistema nervioso central (SNC) es una red de comunicación extraordinaria y compleja que recibe cantidades voluminosas de información simultáneamente, pero es vulnerable a enfermedades y lesiones. Esta investigación enfatiza la importancia de las uniones gap en condiciones neuropatológicas y enfermedades neurodegenerativas. A saber, exploramos el grado de participación de las sinapsis químicas y eléctricas dentro de un panorama actualizado de las técnicas moleculares integrativas utilizadas para su estudio. Se desconoce la cantidad de sinapsis eléctricas y químicas que coexisten en el cerebro humano, pero están presentes en casi todos los tipos de células. Con frecuencia, las sinapsis eléctricas y químicas se encuentran por separado, aunque a veces las sinapsis mixtas quimicoeléctricas se encuentran acopladas. Desafortunadamente, la disfunción sináptica tiene efectos adversos en los órganos y las estructuras vitales. En esta revisión discutimos las enfermedades más comunes derivadas de la disfunción sináptica, así como su ocurrencia en México. Del mismo modo, discutimos los tratamientos actuales para padecimientos neurológicos que involucran conexinas humanas. Los estudios sobre el SNC son importantes para comprender cómo funciona este sistema y explicar los mecanismos de acción actuales utilizados como tratamientos de neuropatologías. [ABSTRACT FROM AUTHOR] |
| Copyright of Revista Mexicana de Neurociencia is the property of Academia Mexicana de Neurologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 143339794 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Synapses and neural communication in neuropathological conditions. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Sinapsis y comunicación neuronal en afecciones neuropatológicas. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sánchez%2C+Alejandro%22">Sánchez, Alejandro</searchLink><relatesTo>1</relatesTo><i> alejandroSG@uabc.edu.mx</i><br /><searchLink fieldCode="AR" term="%22Flores%2C+Dora+L%2E%22">Flores, Dora L.</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Leyva%2C+Eugenio%22">Leyva, Eugenio</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Castro%2C+Carlos%22">Castro, Carlos</searchLink><relatesTo>2</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Revista+Mexicana+de+Neurociencia%22">Revista Mexicana de Neurociencia</searchLink>. May/Jun2020, Vol. 21 Issue 3, p111-121. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22SYNAPSES%22">SYNAPSES</searchLink><br /><searchLink fieldCode="DE" term="%22GAP+junctions+%28Cell+biology%29%22">GAP junctions (Cell biology)</searchLink><br /><searchLink fieldCode="DE" term="%22TREATMENT+of+neurodegeneration%22">TREATMENT of neurodegeneration</searchLink><br /><searchLink fieldCode="DE" term="%22NEUROLOGICAL+disorders%22">NEUROLOGICAL disorders</searchLink><br /><searchLink fieldCode="DE" term="%22CELL+communication%22">CELL communication</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: The central nervous system (CNS) is an extraordinary and complex communication network that receives voluminous amounts of information simultaneously but is vulnerable to disease and injury. This research emphasizes on the importance of gap junctions in neuropathological conditions and neurodegenerative diseases. Namely, we explore the degree of participation of chemical and electrical synapses within an updated panorama of integrative molecular techniques used for their study. The number of electrical and chemical synapses that coexist in the human brain is unknown, yet they are present in almost all types of cells. Frequently, electrical and chemical synapses are found separately, yet sometimes mixed electrical-chemical synapses are found coupled or together. Unfortunately, synaptic dysfunction has adverse effects on organs and vital structures. In this review, we discuss the most common diseases derived from synaptic dysfunction, as well as their occurrence in Mexico. Similarly, we discuss current treatments for diseases involving human connexins. Studies on the CNS are important to understand how this system works and explain current action mechanisms used as treatments of neuropathologies. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: El sistema nervioso central (SNC) es una red de comunicación extraordinaria y compleja que recibe cantidades voluminosas de información simultáneamente, pero es vulnerable a enfermedades y lesiones. Esta investigación enfatiza la importancia de las uniones gap en condiciones neuropatológicas y enfermedades neurodegenerativas. A saber, exploramos el grado de participación de las sinapsis químicas y eléctricas dentro de un panorama actualizado de las técnicas moleculares integrativas utilizadas para su estudio. Se desconoce la cantidad de sinapsis eléctricas y químicas que coexisten en el cerebro humano, pero están presentes en casi todos los tipos de células. Con frecuencia, las sinapsis eléctricas y químicas se encuentran por separado, aunque a veces las sinapsis mixtas quimicoeléctricas se encuentran acopladas. Desafortunadamente, la disfunción sináptica tiene efectos adversos en los órganos y las estructuras vitales. En esta revisión discutimos las enfermedades más comunes derivadas de la disfunción sináptica, así como su ocurrencia en México. Del mismo modo, discutimos los tratamientos actuales para padecimientos neurológicos que involucran conexinas humanas. Los estudios sobre el SNC son importantes para comprender cómo funciona este sistema y explicar los mecanismos de acción actuales utilizados como tratamientos de neuropatologías. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Revista Mexicana de Neurociencia is the property of Academia Mexicana de Neurologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=143339794 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.24875/RMN.20000136 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 111 Subjects: – SubjectFull: SYNAPSES Type: general – SubjectFull: GAP junctions (Cell biology) Type: general – SubjectFull: TREATMENT of neurodegeneration Type: general – SubjectFull: NEUROLOGICAL disorders Type: general – SubjectFull: CELL communication Type: general Titles: – TitleFull: Synapses and neural communication in neuropathological conditions. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sánchez, Alejandro – PersonEntity: Name: NameFull: Flores, Dora L. – PersonEntity: Name: NameFull: Leyva, Eugenio – PersonEntity: Name: NameFull: Castro, Carlos IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May/Jun2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 16655044 Numbering: – Type: volume Value: 21 – Type: issue Value: 3 Titles: – TitleFull: Revista Mexicana de Neurociencia Type: main |
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