¿A QUÉ PREGUNTA RESPONDE "EL HUESO"? Una cuestión de direccionalidad estructural y organización biológica (Hueso y huesos, del big-bang a la osteoporosis).
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| Title: | ¿A QUÉ PREGUNTA RESPONDE "EL HUESO"? Una cuestión de direccionalidad estructural y organización biológica (Hueso y huesos, del big-bang a la osteoporosis). |
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| Alternate Title: | TO WHAT QUESTION IS 'BONE' THE ANSWER? A matter of structural directionality and biological organization (Bone and bones, from the Big Bang to osteoporosis). |
| Authors: | Ferretti, José Luis1, Pilot, Nicolás2, Pisani, Leandro2, Lüscher, Sergio1, Mackler, Leandro1, Cointry, Gustavo Roberto1 gcointry@gmail.com, Capozza, Ricardo Francisco1 |
| Source: | Actualizaciones en Osteología. Ene-Apr2020, Vol. 16 Issue 1, p47-66. 20p. |
| Subjects: | BONES, MECHANICAL ability, BONE cells, NATURAL selection, BONE mechanics, GENETICS |
| Abstract (English): | The nature of the general behavior of our bones as weight-bearing structures is a matter of two biological concepts, namely, structure and organization, which are relevant to properly interpret, diagnose, treat, and monitor all bone-weakening diseases. Different approaches can be proposed to trace the corresponding relationships. The one we present here involves six congruent criteria, namely, 1) a cosmological proposal of a common origin for everything; 2) a biological acknowledgement of a common origin for all bones; 3) the epistemological questioning of our understanding of the concrete concept of structure and the abstract notion of organization, focused on the lead idea of directionality; 4) the ecological insight that emphasizes the relevance of the mechanical environment of every organism to the naturally-selected adjustment of the mechanical properties of their mobile bones to act as struts or levers; 5) The clinical aspects of all the alluded associations; 6) The central role of bone cells to control the genetics/environment interactions of any individual as needed to optimize the directionality of the structure of each of his/her bones to keep their mechanical ability within physiological limits. From our point of view, we could only solve the riddle posed by the title by addressing all of these six criteria. The striking conclusion of our analysis suggests that the structure (not the mass) of every bone would be controlled not only to take care of its mechanical ability, but also to cope with other properties which show a higher priority concerning natural selection. The matter would be that this interpretation of bone behavior and 'function' should affect the rationales for most pharmacological indications currently made to take care of bone fragility. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | La "razón de ser" de nuestros huesos y esqueletos constituye un dilema centralizado en los conceptos biológicos de "estructura" y "organización", cuya solución necesitamos comprender para interpretar, diagnosticar, tratar y monitorear correctamente las osteopatías fragilizantes. Últimamente se ha reunido conocimiento suficiente para proponer aproximaciones razonables a ese objetivo. La que exponemos aquí requiere la aplicación de no menos de 6 criterios congruentes: 1) Un criterio cosmológico, que propone un origen común para todas las cosas; 2) Un criterio biológico, que explica el origen común de todos los huesos; 3) Un enfoque epistemológico, que desafía nuestra capacidad de comprensión del concepto concreto de estructura y del concepto abstracto de organización, focalizada en la noción rectora de direccionalidad espacial; 4) Una visión ecológica, que destaca la importancia del entorno mecánico de cada organismo para la adecuación de la calidad mecánica de sus huesos a las "funciones de sostén" que les adjudicamos; 5) Una correlación entre todo ese conocimiento y el necesario para optimizar nuestra aptitud para resolver los problemas clínicos implicados y 6) Una jerarquización del papel celular en el manejo de las interacciones genético-ambientales necesario para asimilar todo el problema a una simple cuestión de organización direccional de la estructura de cada hueso. Solo aplicando estos 6 criterios estaríamos en condiciones de responder a la incógnita planteada por el título. La conclusión de esta interpretación de la conducta y función de los huesos debería afectar el fundamento de la mayoría de las indicaciones farmacológicas destinadas al tratamiento de la fragilidad ósea. [ABSTRACT FROM AUTHOR] |
| Copyright of Actualizaciones en Osteología is the property of Asociacion Argentina de Osteologia y Metabolismo Mineral and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 145388805 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: ¿A QUÉ PREGUNTA RESPONDE "EL HUESO"? Una cuestión de direccionalidad estructural y organización biológica (Hueso y huesos, del big-bang a la osteoporosis). – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: TO WHAT QUESTION IS 'BONE' THE ANSWER? A matter of structural directionality and biological organization (Bone and bones, from the Big Bang to osteoporosis). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ferretti%2C+José+Luis%22">Ferretti, José Luis</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Pilot%2C+Nicolás%22">Pilot, Nicolás</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Pisani%2C+Leandro%22">Pisani, Leandro</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Lüscher%2C+Sergio%22">Lüscher, Sergio</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Mackler%2C+Leandro%22">Mackler, Leandro</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cointry%2C+Gustavo+Roberto%22">Cointry, Gustavo Roberto</searchLink><relatesTo>1</relatesTo><i> gcointry@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Capozza%2C+Ricardo+Francisco%22">Capozza, Ricardo Francisco</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Actualizaciones+en+Osteología%22">Actualizaciones en Osteología</searchLink>. Ene-Apr2020, Vol. 16 Issue 1, p47-66. 20p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22BONES%22">BONES</searchLink><br /><searchLink fieldCode="DE" term="%22MECHANICAL+ability%22">MECHANICAL ability</searchLink><br /><searchLink fieldCode="DE" term="%22BONE+cells%22">BONE cells</searchLink><br /><searchLink fieldCode="DE" term="%22NATURAL+selection%22">NATURAL selection</searchLink><br /><searchLink fieldCode="DE" term="%22BONE+mechanics%22">BONE mechanics</searchLink><br /><searchLink fieldCode="DE" term="%22GENETICS%22">GENETICS</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: The nature of the general behavior of our bones as weight-bearing structures is a matter of two biological concepts, namely, structure and organization, which are relevant to properly interpret, diagnose, treat, and monitor all bone-weakening diseases. Different approaches can be proposed to trace the corresponding relationships. The one we present here involves six congruent criteria, namely, 1) a cosmological proposal of a common origin for everything; 2) a biological acknowledgement of a common origin for all bones; 3) the epistemological questioning of our understanding of the concrete concept of structure and the abstract notion of organization, focused on the lead idea of directionality; 4) the ecological insight that emphasizes the relevance of the mechanical environment of every organism to the naturally-selected adjustment of the mechanical properties of their mobile bones to act as struts or levers; 5) The clinical aspects of all the alluded associations; 6) The central role of bone cells to control the genetics/environment interactions of any individual as needed to optimize the directionality of the structure of each of his/her bones to keep their mechanical ability within physiological limits. From our point of view, we could only solve the riddle posed by the title by addressing all of these six criteria. The striking conclusion of our analysis suggests that the structure (not the mass) of every bone would be controlled not only to take care of its mechanical ability, but also to cope with other properties which show a higher priority concerning natural selection. The matter would be that this interpretation of bone behavior and 'function' should affect the rationales for most pharmacological indications currently made to take care of bone fragility. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: La "razón de ser" de nuestros huesos y esqueletos constituye un dilema centralizado en los conceptos biológicos de "estructura" y "organización", cuya solución necesitamos comprender para interpretar, diagnosticar, tratar y monitorear correctamente las osteopatías fragilizantes. Últimamente se ha reunido conocimiento suficiente para proponer aproximaciones razonables a ese objetivo. La que exponemos aquí requiere la aplicación de no menos de 6 criterios congruentes: 1) Un criterio cosmológico, que propone un origen común para todas las cosas; 2) Un criterio biológico, que explica el origen común de todos los huesos; 3) Un enfoque epistemológico, que desafía nuestra capacidad de comprensión del concepto concreto de estructura y del concepto abstracto de organización, focalizada en la noción rectora de direccionalidad espacial; 4) Una visión ecológica, que destaca la importancia del entorno mecánico de cada organismo para la adecuación de la calidad mecánica de sus huesos a las "funciones de sostén" que les adjudicamos; 5) Una correlación entre todo ese conocimiento y el necesario para optimizar nuestra aptitud para resolver los problemas clínicos implicados y 6) Una jerarquización del papel celular en el manejo de las interacciones genético-ambientales necesario para asimilar todo el problema a una simple cuestión de organización direccional de la estructura de cada hueso. Solo aplicando estos 6 criterios estaríamos en condiciones de responder a la incógnita planteada por el título. La conclusión de esta interpretación de la conducta y función de los huesos debería afectar el fundamento de la mayoría de las indicaciones farmacológicas destinadas al tratamiento de la fragilidad ósea. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Actualizaciones en Osteología is the property of Asociacion Argentina de Osteologia y Metabolismo Mineral and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 20 StartPage: 47 Subjects: – SubjectFull: BONES Type: general – SubjectFull: MECHANICAL ability Type: general – SubjectFull: BONE cells Type: general – SubjectFull: NATURAL selection Type: general – SubjectFull: BONE mechanics Type: general – SubjectFull: GENETICS Type: general Titles: – TitleFull: ¿A QUÉ PREGUNTA RESPONDE "EL HUESO"? Una cuestión de direccionalidad estructural y organización biológica (Hueso y huesos, del big-bang a la osteoporosis). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ferretti, José Luis – PersonEntity: Name: NameFull: Pilot, Nicolás – PersonEntity: Name: NameFull: Pisani, Leandro – PersonEntity: Name: NameFull: Lüscher, Sergio – PersonEntity: Name: NameFull: Mackler, Leandro – PersonEntity: Name: NameFull: Cointry, Gustavo Roberto – PersonEntity: Name: NameFull: Capozza, Ricardo Francisco IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Ene-Apr2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 16698975 Numbering: – Type: volume Value: 16 – Type: issue Value: 1 Titles: – TitleFull: Actualizaciones en Osteología Type: main |
| ResultId | 1 |
