Biomarkers of susceptibility and effect in car painters exposed to organic solvents.
Saved in:
| Title: | Biomarkers of susceptibility and effect in car painters exposed to organic solvents. |
|---|---|
| Alternate Title: | Biomarcadores de susceptibilidad y efecto en pintores de carros expuestos a solventes orgánicos. |
| Authors: | Varona-Uribe, Marcela1 marcela.varona@urosario.edu.co, Ibáñez-Pinilla, Milcíades1, Briceno-Ayala, Leonardo1, Herrera, Diego1, Chuaire-Noack, Lilian2, Martínez-Agüero, María3, Sánchez Corredor, Magda Carolina3, Palma-Parra, Ruth4, Narvaez, Diana5, Groot de Restrepo, Helena5 |
| Source: | Colombia Medica. 2020, Vol. 51 Issue 1, p1-12. 12p. |
| Subjects: | TUMOR risk factors, ALLELES, AUTOMOBILES, BIOMARKERS, CELL nuclei, DISEASE susceptibility, GENETIC polymorphisms, LYMPHOCYTES, ORGANIC compounds, PAINT, CROSS-sectional method, GENOTYPES, OCCUPATIONAL exposure |
| Abstract (English): | Introduction: Car painters are routinely exposed to organic solvents classified as carcinogenic and mutagenic substances. Objective: To characterize the population susceptibility and evaluate the genotoxic effects of exposure to organic solvents. Methods: A cross-sectional study comparing a group of car painters exposed to organic solvents with a non-exposed group. CYP2E1 polymorphisms and the presence of micronuclei in lymphocytes were determined. Results: One hundred twenty-two workers participated in the study: 62 who worked in car paint shops and were exposed to solvents, and 60 who were not exposed. There were statistically significant differences between the two groups regarding micronucleated cells and nucleoplasmic bridges frequencies (p= 0.042 and p= 0.046, respectively; exact likelihood ratio). Significant differences were found at the interaction between the CYP2E1 genotype c1c1 and occupational exposure to solvents, with higher frequencies of micronuclei (p= 0.013) and micronucleated cells (p= 0.015). However, when the frequencies of micronuclei, micronucleated cells and nucleoplasmic bridges in the exposure group were compared between the c1c1 and c2c2/c1c2 allele groups of the CYP2E1 polymorphism, statistically significant differences were found. Conclusions: This study confirms that when workers with CYP2E1 polymorphisms, specifically the c1c1 genotype, are exposed to organic solvents, they are more likely to have somatic cell mutations, a condition associated with increased susceptibility to diseases such as cancer. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Introducción: Los pintores de vehículos automotores están rutinariamente expuestos a agentes como los solventes orgánicos, capaces de producir efectos mutágenos y carcinógenos. Objetivo: Caracterizar la susceptibilidad poblacional y evaluar los efectos genotóxicos debidos a la exposición a solventes orgánicos. Métodos: Estudio de corte transversal que comparó a un grupo de pintores de carros expuestos a solventes orgánicos con un grupo de personas no expuestas. Fueron determinados tanto los polimorfismos de CYP2E1 como la presencia de micronúcleos en linfocitos. Resultados: Participaron 122 personas, 62 trabajadores de talleres de pintura de autos expuestos a solventes y 60 personas no expuestas. Con relación al cuestionario Q 16, 32% de los expuestos refirieron síntomas sugestivos de neurotoxicidad. Las frecuencias de células micronucleadas y de puentes nucleoplásmicos fueron significativamente mayores en los expuestos que en los no expuestos: p= 0.042 y p= 0.046, respectivamente, Razón de verosimilitud exacta). Fueron halladas diferencias significativas en la interacción de CYP2E1 (c1c1) y la exposición ocupacional a solventes, con mayores frecuencias de micronúcleos (p= 0.013) y de células micronucleadas (p= 0.015). Conclusiones: Este estudio reafirma que los trabajadores expuestos a solventes orgánicos con polimorfismos de CYP2E1, específicamente con genotipo c1c1, tienen mayor probabilidad de presentar mutaciones en las células somáticas, condición asociada con una mayor susceptibilidad a enfermedades como el cáncer. [ABSTRACT FROM AUTHOR] |
| Copyright of Colombia Medica is the property of Universidad del Valle and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: lth DbLabel: MedicLatina An: 148421766 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Biomarkers of susceptibility and effect in car painters exposed to organic solvents. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Biomarcadores de susceptibilidad y efecto en pintores de carros expuestos a solventes orgánicos. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Varona-Uribe%2C+Marcela%22">Varona-Uribe, Marcela</searchLink><relatesTo>1</relatesTo><i> marcela.varona@urosario.edu.co</i><br /><searchLink fieldCode="AR" term="%22Ibáñez-Pinilla%2C+Milcíades%22">Ibáñez-Pinilla, Milcíades</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Briceno-Ayala%2C+Leonardo%22">Briceno-Ayala, Leonardo</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Herrera%2C+Diego%22">Herrera, Diego</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Chuaire-Noack%2C+Lilian%22">Chuaire-Noack, Lilian</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Martínez-Agüero%2C+María%22">Martínez-Agüero, María</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Sánchez+Corredor%2C+Magda+Carolina%22">Sánchez Corredor, Magda Carolina</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Palma-Parra%2C+Ruth%22">Palma-Parra, Ruth</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Narvaez%2C+Diana%22">Narvaez, Diana</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Groot+de+Restrepo%2C+Helena%22">Groot de Restrepo, Helena</searchLink><relatesTo>5</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Colombia+Medica%22">Colombia Medica</searchLink>. 2020, Vol. 51 Issue 1, p1-12. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22TUMOR+risk+factors%22">TUMOR risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22ALLELES%22">ALLELES</searchLink><br /><searchLink fieldCode="DE" term="%22AUTOMOBILES%22">AUTOMOBILES</searchLink><br /><searchLink fieldCode="DE" term="%22BIOMARKERS%22">BIOMARKERS</searchLink><br /><searchLink fieldCode="DE" term="%22CELL+nuclei%22">CELL nuclei</searchLink><br /><searchLink fieldCode="DE" term="%22DISEASE+susceptibility%22">DISEASE susceptibility</searchLink><br /><searchLink fieldCode="DE" term="%22GENETIC+polymorphisms%22">GENETIC polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22LYMPHOCYTES%22">LYMPHOCYTES</searchLink><br /><searchLink fieldCode="DE" term="%22ORGANIC+compounds%22">ORGANIC compounds</searchLink><br /><searchLink fieldCode="DE" term="%22PAINT%22">PAINT</searchLink><br /><searchLink fieldCode="DE" term="%22CROSS-sectional+method%22">CROSS-sectional method</searchLink><br /><searchLink fieldCode="DE" term="%22GENOTYPES%22">GENOTYPES</searchLink><br /><searchLink fieldCode="DE" term="%22OCCUPATIONAL+exposure%22">OCCUPATIONAL exposure</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Introduction: Car painters are routinely exposed to organic solvents classified as carcinogenic and mutagenic substances. Objective: To characterize the population susceptibility and evaluate the genotoxic effects of exposure to organic solvents. Methods: A cross-sectional study comparing a group of car painters exposed to organic solvents with a non-exposed group. CYP2E1 polymorphisms and the presence of micronuclei in lymphocytes were determined. Results: One hundred twenty-two workers participated in the study: 62 who worked in car paint shops and were exposed to solvents, and 60 who were not exposed. There were statistically significant differences between the two groups regarding micronucleated cells and nucleoplasmic bridges frequencies (p= 0.042 and p= 0.046, respectively; exact likelihood ratio). Significant differences were found at the interaction between the CYP2E1 genotype c1c1 and occupational exposure to solvents, with higher frequencies of micronuclei (p= 0.013) and micronucleated cells (p= 0.015). However, when the frequencies of micronuclei, micronucleated cells and nucleoplasmic bridges in the exposure group were compared between the c1c1 and c2c2/c1c2 allele groups of the CYP2E1 polymorphism, statistically significant differences were found. Conclusions: This study confirms that when workers with CYP2E1 polymorphisms, specifically the c1c1 genotype, are exposed to organic solvents, they are more likely to have somatic cell mutations, a condition associated with increased susceptibility to diseases such as cancer. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Introducción: Los pintores de vehículos automotores están rutinariamente expuestos a agentes como los solventes orgánicos, capaces de producir efectos mutágenos y carcinógenos. Objetivo: Caracterizar la susceptibilidad poblacional y evaluar los efectos genotóxicos debidos a la exposición a solventes orgánicos. Métodos: Estudio de corte transversal que comparó a un grupo de pintores de carros expuestos a solventes orgánicos con un grupo de personas no expuestas. Fueron determinados tanto los polimorfismos de CYP2E1 como la presencia de micronúcleos en linfocitos. Resultados: Participaron 122 personas, 62 trabajadores de talleres de pintura de autos expuestos a solventes y 60 personas no expuestas. Con relación al cuestionario Q 16, 32% de los expuestos refirieron síntomas sugestivos de neurotoxicidad. Las frecuencias de células micronucleadas y de puentes nucleoplásmicos fueron significativamente mayores en los expuestos que en los no expuestos: p= 0.042 y p= 0.046, respectivamente, Razón de verosimilitud exacta). Fueron halladas diferencias significativas en la interacción de CYP2E1 (c1c1) y la exposición ocupacional a solventes, con mayores frecuencias de micronúcleos (p= 0.013) y de células micronucleadas (p= 0.015). Conclusiones: Este estudio reafirma que los trabajadores expuestos a solventes orgánicos con polimorfismos de CYP2E1, específicamente con genotipo c1c1, tienen mayor probabilidad de presentar mutaciones en las células somáticas, condición asociada con una mayor susceptibilidad a enfermedades como el cáncer. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Colombia Medica is the property of Universidad del Valle and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=148421766 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.25100/cm.v51i1.3646 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 1 Subjects: – SubjectFull: TUMOR risk factors Type: general – SubjectFull: ALLELES Type: general – SubjectFull: AUTOMOBILES Type: general – SubjectFull: BIOMARKERS Type: general – SubjectFull: CELL nuclei Type: general – SubjectFull: DISEASE susceptibility Type: general – SubjectFull: GENETIC polymorphisms Type: general – SubjectFull: LYMPHOCYTES Type: general – SubjectFull: ORGANIC compounds Type: general – SubjectFull: PAINT Type: general – SubjectFull: CROSS-sectional method Type: general – SubjectFull: GENOTYPES Type: general – SubjectFull: OCCUPATIONAL exposure Type: general Titles: – TitleFull: Biomarkers of susceptibility and effect in car painters exposed to organic solvents. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Varona-Uribe, Marcela – PersonEntity: Name: NameFull: Ibáñez-Pinilla, Milcíades – PersonEntity: Name: NameFull: Briceno-Ayala, Leonardo – PersonEntity: Name: NameFull: Herrera, Diego – PersonEntity: Name: NameFull: Chuaire-Noack, Lilian – PersonEntity: Name: NameFull: Martínez-Agüero, María – PersonEntity: Name: NameFull: Sánchez Corredor, Magda Carolina – PersonEntity: Name: NameFull: Palma-Parra, Ruth – PersonEntity: Name: NameFull: Narvaez, Diana – PersonEntity: Name: NameFull: Groot de Restrepo, Helena IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 01208322 Numbering: – Type: volume Value: 51 – Type: issue Value: 1 Titles: – TitleFull: Colombia Medica Type: main |
| ResultId | 1 |
