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Caracterización de la plaquetopenia, leucopenia y aumento del hematocrito en la evolución y gravedad de los pacientes con diagnóstico de dengue.

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Title: Caracterización de la plaquetopenia, leucopenia y aumento del hematocrito en la evolución y gravedad de los pacientes con diagnóstico de dengue.
Alternate Title: Characterization of thrombocytopenia, leukopenia and increased hematocrit in the evolution and severity of patients with dengue diagnosis.
Authors: Ortega Martinez, Rommer Alex1 rommeralexo@gmail.com, Cáceres Sanchez, Liliana Alejandra2, Borda de Abularach, Jacqueline3
Source: Gaceta Médica Boliviana. ene-jun2021, Vol. 44 Issue 1, p19-28. 10p.
Abstract (English): Dengue virus (DENV) has haunted our planet for more than three centuries. The Aedes aegypti bite causes DENV. Clinical and laboratory diagnosis are important for the management of dengue. Objective: to characterize the presence of plaquetopenia, leukopenia and increased hematocrit with the evolution and severity of patients with Dengue, Hospital Univalle. Material and methods: retrospective, longitudinal and analytical study, 2017 to 2020. Results: 235 patients were identified, 83% in 2020; 65% between 19 to 45 years old; the male sex with 54%. 80% come from Cercado-Cochabamba, of these more than 95% from the southern area. The test with the detection of the NS1Ag protein (AccuBio Tech Co, Ltd.) was used in 71%; 56% were hospitalized; more than 50% presented symptoms between the 2nd and 5th day; Within the dengue classification, 75% belonged to dengue without warning signs (p = <0,01). Fever (p = 0,001), associated with symptoms of alarm such as abdominal pain, persistent vomiting, and bleeding (p = <0,05) were frequent. Leukopenia <5 000 / mm3 was common in women with warning signs, in contrast to men; thrombocytopenia in patients with warning signs and in men; hematocrit> 45% in men and represented more than 5 days of hospitalization (p = 0,023). Conclusions: Plaquetopenia, leukopenia and increased hematocrit are biomarkers of clinical severity, hospital stay, associated with an early diagnosis, using the symptoms and rapid tests available; finally, consider the presence of autochthonous patients from the southern area of Cochabamba, Cercado. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): El virus del dengue (DENV) ha frecuentado nuestro planeta por más de tres siglos. La picadura del Aedes aegypti causa el DENV. El diagnóstico clínico y laboratorial son importantes para el manejo del dengue. Objetivo: caracterizar la presencia de la plaquetopenia, leucopenia y aumento del hematocrito con la evolución y gravedad de los pacientes con Dengue, en el Hospital Univalle, en la ciudad de Cochabamba, Bolivia. Material y métodos: estudio retrospectivo, longitudinal y analítico, desde el 2017 al 2020. Resultados: se identificaron 235 pacientes, 83% el 2020; el 65% entre 19 a 45 años; 54% de sexo masculino, 80% provienen de Cercado-Cochabamba, siendo más del 95% de la zona sud. La prueba de detección de la proteína NS1Ag (AccuBio Tech Co, Ltd.) se usó en 71%; 56% se hospitalizaron; más del 50% presentaron sintomatología entre el 2do y 5to día. Dentro la clasificación del dengue, el 75% perteneció a dengue sin signos de alarma (p=<0,01). La fiebre (p=0,001), asociada a la clínica con signos de alarma como el dolor abdominal, vomito persistente y sangrado (p=< 0,05) fueron frecuentes. Leucopenia < a 5 000/mm3 fue común en mujeres con signos de alarma, en contraposición con los varones; plaquetopenia en pacientes con signos de alarma y en varones; el hematocrito > 45% en varones, presentando más de 5 días de hospitalización (p=0,023). Conclusiones: plaquetopenia, leucopenia y el aumento del hematocrito son biomarcadores de severidad clínica y estancia hospitalaria, asociados a un diagnóstico precoz, empleando la sintomatología y pruebas rápidas disponibles; siendo necesario considerar la presencia de pacientes autóctonos de la zona sud de Cochabamba, Cercado. [ABSTRACT FROM AUTHOR]
Copyright of Gaceta Médica Boliviana is the property of Universidad Mayor de San Simon, Facultad de Medicina and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Caracterizaci&#243;n de la plaquetopenia, leucopenia y aumento del hematocrito en la evoluci&#243;n y gravedad de los pacientes con diagn&#243;stico de dengue.
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  Data: Characterization of thrombocytopenia, leukopenia and increased hematocrit in the evolution and severity of patients with dengue diagnosis.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Gaceta+M&#233;dica+Boliviana%22&quot;&gt;Gaceta M&#233;dica Boliviana&lt;/searchLink&gt;. ene-jun2021, Vol. 44 Issue 1, p19-28. 10p.
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Dengue virus (DENV) has haunted our planet for more than three centuries. The Aedes aegypti bite causes DENV. Clinical and laboratory diagnosis are important for the management of dengue. Objective: to characterize the presence of plaquetopenia, leukopenia and increased hematocrit with the evolution and severity of patients with Dengue, Hospital Univalle. Material and methods: retrospective, longitudinal and analytical study, 2017 to 2020. Results: 235 patients were identified, 83% in 2020; 65% between 19 to 45 years old; the male sex with 54%. 80% come from Cercado-Cochabamba, of these more than 95% from the southern area. The test with the detection of the NS1Ag protein (AccuBio Tech Co, Ltd.) was used in 71%; 56% were hospitalized; more than 50% presented symptoms between the 2nd and 5th day; Within the dengue classification, 75% belonged to dengue without warning signs (p = &lt;0,01). Fever (p = 0,001), associated with symptoms of alarm such as abdominal pain, persistent vomiting, and bleeding (p = &lt;0,05) were frequent. Leukopenia &lt;5 000 / mm3 was common in women with warning signs, in contrast to men; thrombocytopenia in patients with warning signs and in men; hematocrit&gt; 45% in men and represented more than 5 days of hospitalization (p = 0,023). Conclusions: Plaquetopenia, leukopenia and increased hematocrit are biomarkers of clinical severity, hospital stay, associated with an early diagnosis, using the symptoms and rapid tests available; finally, consider the presence of autochthonous patients from the southern area of Cochabamba, Cercado. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: El virus del dengue (DENV) ha frecuentado nuestro planeta por m&#225;s de tres siglos. La picadura del Aedes aegypti causa el DENV. El diagn&#243;stico cl&#237;nico y laboratorial son importantes para el manejo del dengue. Objetivo: caracterizar la presencia de la plaquetopenia, leucopenia y aumento del hematocrito con la evoluci&#243;n y gravedad de los pacientes con Dengue, en el Hospital Univalle, en la ciudad de Cochabamba, Bolivia. Material y m&#233;todos: estudio retrospectivo, longitudinal y anal&#237;tico, desde el 2017 al 2020. Resultados: se identificaron 235 pacientes, 83% el 2020; el 65% entre 19 a 45 a&#241;os; 54% de sexo masculino, 80% provienen de Cercado-Cochabamba, siendo m&#225;s del 95% de la zona sud. La prueba de detecci&#243;n de la prote&#237;na NS1Ag (AccuBio Tech Co, Ltd.) se us&#243; en 71%; 56% se hospitalizaron; m&#225;s del 50% presentaron sintomatolog&#237;a entre el 2do y 5to d&#237;a. Dentro la clasificaci&#243;n del dengue, el 75% perteneci&#243; a dengue sin signos de alarma (p=&lt;0,01). La fiebre (p=0,001), asociada a la cl&#237;nica con signos de alarma como el dolor abdominal, vomito persistente y sangrado (p=&lt; 0,05) fueron frecuentes. Leucopenia &lt; a 5 000/mm3 fue com&#250;n en mujeres con signos de alarma, en contraposici&#243;n con los varones; plaquetopenia en pacientes con signos de alarma y en varones; el hematocrito &gt; 45% en varones, presentando m&#225;s de 5 d&#237;as de hospitalizaci&#243;n (p=0,023). Conclusiones: plaquetopenia, leucopenia y el aumento del hematocrito son biomarcadores de severidad cl&#237;nica y estancia hospitalaria, asociados a un diagn&#243;stico precoz, empleando la sintomatolog&#237;a y pruebas r&#225;pidas disponibles; siendo necesario considerar la presencia de pacientes aut&#243;ctonos de la zona sud de Cochabamba, Cercado. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Gaceta M&#233;dica Boliviana is the property of Universidad Mayor de San Simon, Facultad de Medicina and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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              Text: ene-jun2021
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