Bacteremia after Bacillus clausii administration for the treatment of acute diarrhea: A case report.

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Title: Bacteremia after Bacillus clausii administration for the treatment of acute diarrhea: A case report.
Alternate Title: Bacteriemia tras la administración de Bacillus clausii para el tratamiento de la diarrea aguda: reporte de un caso.
Authors: Pablo García, Juan1 juan.garcia@utp.edu.co, Alexander Alzate, John2, Andrés Hoyos, Julián2, Cristancho, Edilberto3
Source: Biomédica: Revista del Instituto Nacional de Salud. 2021 Supplement, Vol. 41, p13-20. 8p.
Subjects: BACTEREMIA, DIARRHEA, MEDICAL personnel, PEPTIC ulcer, PROBIOTICS
Abstract (English): Bacillus clausii is a gram-positive rod used as a probiotic to treat diarrhea and the side effects of antibiotics such as pseudomembranous colitis. We report a case of B. clausii bacteremia in a non-immunocompromised patient with active peptic ulcer disease and acute diarrhea. The probiotic was administered during the patient's hospitalization due to diarrhea of infectious origin. B. clausii was identified in the bloodstream of the patient through Matrix-Assisted Laser Desorption Ionization-Time of Flight (MALDI-TOF) days after her discharge. Given the wide use of probiotics, we alert clinicians to consider this microorganism as a causative agent when signs of systemic infection, metabolic compromise, and hemodynamic instability establish after its administration and no pathogens have been identified that could explain the clinical course. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Bacillus clausii es un bacilo Gram positivo usado como probiótico para tratar la diarrea y efectos adversos de los antibióticos, como la colitis pseudomembranosa. Se reporta un caso de bacteriemia por B. clausii en una paciente inmunocompetente con enfermedad ulcerosa péptica activa y diarrea aguda. El probiótico le fue administrado durante la hospitalización debido al origen infeccioso de la diarrea. B. clausii se identificó en el torrente sanguíneo de la paciente, utilizando espectrometría de desorción/ionización mediante láser asistido por matriz (Matrix-Assisted Laser Desorption/Ionization, MALDI), acoplada a un detector de iones (Time of Flight, TOF) (MALDI-TOF), días después de haber sido dada de alta. Dado el amplio uso de los probióticos, alertamos a los clínicos para que consideren este microorganismo como agente causal cuando se detecten signos de infección sistémica, compromiso metabólico, e inestabilidad hemodinámica tras su administración, y no se haya identificado ningún patógeno que pueda explicar el cuadro clínico. [ABSTRACT FROM AUTHOR]
Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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  Data: Bacteremia after Bacillus clausii administration for the treatment of acute diarrhea: A case report.
– Name: TitleAlt
  Label: Alternate Title
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  Data: Bacteriemia tras la administración de Bacillus clausii para el tratamiento de la diarrea aguda: reporte de un caso.
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  Data: <searchLink fieldCode="AR" term="%22Pablo+García%2C+Juan%22">Pablo García, Juan</searchLink><relatesTo>1</relatesTo><i> juan.garcia@utp.edu.co</i><br /><searchLink fieldCode="AR" term="%22Alexander+Alzate%2C+John%22">Alexander Alzate, John</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Andrés+Hoyos%2C+Julián%22">Andrés Hoyos, Julián</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Cristancho%2C+Edilberto%22">Cristancho, Edilberto</searchLink><relatesTo>3</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Biomédica%3A+Revista+del+Instituto+Nacional+de+Salud%22">Biomédica: Revista del Instituto Nacional de Salud</searchLink>. 2021 Supplement, Vol. 41, p13-20. 8p.
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  Data: <searchLink fieldCode="DE" term="%22BACTEREMIA%22">BACTEREMIA</searchLink><br /><searchLink fieldCode="DE" term="%22DIARRHEA%22">DIARRHEA</searchLink><br /><searchLink fieldCode="DE" term="%22MEDICAL+personnel%22">MEDICAL personnel</searchLink><br /><searchLink fieldCode="DE" term="%22PEPTIC+ulcer%22">PEPTIC ulcer</searchLink><br /><searchLink fieldCode="DE" term="%22PROBIOTICS%22">PROBIOTICS</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Bacillus clausii is a gram-positive rod used as a probiotic to treat diarrhea and the side effects of antibiotics such as pseudomembranous colitis. We report a case of B. clausii bacteremia in a non-immunocompromised patient with active peptic ulcer disease and acute diarrhea. The probiotic was administered during the patient's hospitalization due to diarrhea of infectious origin. B. clausii was identified in the bloodstream of the patient through Matrix-Assisted Laser Desorption Ionization-Time of Flight (MALDI-TOF) days after her discharge. Given the wide use of probiotics, we alert clinicians to consider this microorganism as a causative agent when signs of systemic infection, metabolic compromise, and hemodynamic instability establish after its administration and no pathogens have been identified that could explain the clinical course. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Bacillus clausii es un bacilo Gram positivo usado como probiótico para tratar la diarrea y efectos adversos de los antibióticos, como la colitis pseudomembranosa. Se reporta un caso de bacteriemia por B. clausii en una paciente inmunocompetente con enfermedad ulcerosa péptica activa y diarrea aguda. El probiótico le fue administrado durante la hospitalización debido al origen infeccioso de la diarrea. B. clausii se identificó en el torrente sanguíneo de la paciente, utilizando espectrometría de desorción/ionización mediante láser asistido por matriz (Matrix-Assisted Laser Desorption/Ionization, MALDI), acoplada a un detector de iones (Time of Flight, TOF) (MALDI-TOF), días después de haber sido dada de alta. Dado el amplio uso de los probióticos, alertamos a los clínicos para que consideren este microorganismo como agente causal cuando se detecten signos de infección sistémica, compromiso metabólico, e inestabilidad hemodinámica tras su administración, y no se haya identificado ningún patógeno que pueda explicar el cuadro clínico. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.7705/biomedica.5662
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      – Code: eng
        Text: English
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        PageCount: 8
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    Subjects:
      – SubjectFull: BACTEREMIA
        Type: general
      – SubjectFull: DIARRHEA
        Type: general
      – SubjectFull: MEDICAL personnel
        Type: general
      – SubjectFull: PEPTIC ulcer
        Type: general
      – SubjectFull: PROBIOTICS
        Type: general
    Titles:
      – TitleFull: Bacteremia after Bacillus clausii administration for the treatment of acute diarrhea: A case report.
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            NameFull: Pablo García, Juan
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            NameFull: Alexander Alzate, John
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            NameFull: Andrés Hoyos, Julián
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              M: 10
              Text: 2021 Supplement
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              Y: 2021
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              Value: 41
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