Síndrome de Stevens-Johnson inducido por paracetamol en un paciente pediátrico.
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| Title: | Síndrome de Stevens-Johnson inducido por paracetamol en un paciente pediátrico. |
|---|---|
| Alternate Title: | Stevens-Johnson syndrome induced by paracetamol in a pediatric patient. |
| Authors: | Alonso Rodríguez-Pinzón, Brandon1 alonso.rodpi@gmail.com, Trejo-Chavira, Nohemi2, Alfaro-Sánchez, Abraham Benjamín3, Rodríguez-Cabral, Rebeca del C.4, González-Cabello, Diana |
| Source: | Dermatología Revista Mexicana. Nov/Dec2021, Vol. 65 Issue 6, p991-998. 8p. |
| Abstract (English): | BACKGROUND: Stevens-Johnson syndrome is a rare and life-threatening mucocutaneous disease. Its main etiology is hypersensitivity secondary to drug intake, where carbamazepine, allopurinol and sulfonamides stand out. Paracetamol as a causal agent has been described in only a few reports and case series, predominantly in Asian population. CLINICAL CASE: A 3-years-old male patient with a history of penicillin allergy. He presented erythematous-violaceous macules on the trunk secondary to the administration of paracetamol to relieve abdominal and testicular pain. He went to the emergency room where he received antihistamines and the dose of paracetamol was increased. After this, he began to exhibit blisters and areas of detached skin with systemic affection. Due to this, he was hospitalized in the pediatric intensive care unit where the diagnosis of Stevens-Johnson syndrome was established. His main treatment was focused on immunoglobulin and steroids, with which he presented progressive clinical improvement. CONCLUSIONS: Although most of drug hypersensitivity reactions are limited to mild skin conditions, it is important to recognize that even seemingly innocuous medications, such as paracetamol, can cause severe side reactions like Stevens-Johnson syndrome. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | ANTECEDENTES: El síndrome de Stevens-Johnson es una enfermedad mucocutánea poco frecuente pero potencialmente mortal. Su causa principal es la hipersensibilidad secundaria a la ingesta de fármacos, entre los que destacan carbamazepina, alopurinol y sulfonamidas. El paracetamol, como agente causal, se ha sido reportado poco, con predominio en el continente asiático. CASO CLÍNICO: Paciente masculino de 3 años de edad con antecedente de alergia a penicilina, que inició con máculas eritematovioláceas en el tronco, secundarias a la administración de paracetamol para el alivio de dolor abdominal y testicular. Acudió a urgencias en donde le indicaron antihistamínicos y aumento de la dosis de paracetamol, posterior a lo cual el cuadro se generalizó agregándose ampollas y áreas de piel denudada con afección sistémica. Debido a esto, fue hospitalizado en la unidad de cuidados intensivos pediátricos en donde se estableció el diagnóstico de síndrome de Stevens-Johnson, e inició tratamiento centrado en inmunoglobulina y esteroides con lo que tuvo mejoría clínica progresiva. CONCLUSIONES: Aunque la mayor parte de las reacciones de hipersensibilidad por fármacos se limita a reacciones cutáneas leves, es importante reconocer que aún los medicamentos aparentemente inocuos, como el paracetamol, pueden ser causa de reacciones secundarias severas, como el síndrome de Stevens-Johnson. [ABSTRACT FROM AUTHOR] |
| Copyright of Dermatología Revista Mexicana is the property of Edicion y Farmacia S.A. de C.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 154306287 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Síndrome de Stevens-Johnson inducido por paracetamol en un paciente pediátrico. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Stevens-Johnson syndrome induced by paracetamol in a pediatric patient. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Alonso+Rodríguez-Pinzón%2C+Brandon%22">Alonso Rodríguez-Pinzón, Brandon</searchLink><relatesTo>1</relatesTo><i> alonso.rodpi@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Trejo-Chavira%2C+Nohemi%22">Trejo-Chavira, Nohemi</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Alfaro-Sánchez%2C+Abraham+Benjamín%22">Alfaro-Sánchez, Abraham Benjamín</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Rodríguez-Cabral%2C+Rebeca+del+C%2E%22">Rodríguez-Cabral, Rebeca del C.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22González-Cabello%2C+Diana%22">González-Cabello, Diana</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Dermatología+Revista+Mexicana%22">Dermatología Revista Mexicana</searchLink>. Nov/Dec2021, Vol. 65 Issue 6, p991-998. 8p. – Name: Abstract Label: Abstract (English) Group: Ab Data: BACKGROUND: Stevens-Johnson syndrome is a rare and life-threatening mucocutaneous disease. Its main etiology is hypersensitivity secondary to drug intake, where carbamazepine, allopurinol and sulfonamides stand out. Paracetamol as a causal agent has been described in only a few reports and case series, predominantly in Asian population. CLINICAL CASE: A 3-years-old male patient with a history of penicillin allergy. He presented erythematous-violaceous macules on the trunk secondary to the administration of paracetamol to relieve abdominal and testicular pain. He went to the emergency room where he received antihistamines and the dose of paracetamol was increased. After this, he began to exhibit blisters and areas of detached skin with systemic affection. Due to this, he was hospitalized in the pediatric intensive care unit where the diagnosis of Stevens-Johnson syndrome was established. His main treatment was focused on immunoglobulin and steroids, with which he presented progressive clinical improvement. CONCLUSIONS: Although most of drug hypersensitivity reactions are limited to mild skin conditions, it is important to recognize that even seemingly innocuous medications, such as paracetamol, can cause severe side reactions like Stevens-Johnson syndrome. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: ANTECEDENTES: El síndrome de Stevens-Johnson es una enfermedad mucocutánea poco frecuente pero potencialmente mortal. Su causa principal es la hipersensibilidad secundaria a la ingesta de fármacos, entre los que destacan carbamazepina, alopurinol y sulfonamidas. El paracetamol, como agente causal, se ha sido reportado poco, con predominio en el continente asiático. CASO CLÍNICO: Paciente masculino de 3 años de edad con antecedente de alergia a penicilina, que inició con máculas eritematovioláceas en el tronco, secundarias a la administración de paracetamol para el alivio de dolor abdominal y testicular. Acudió a urgencias en donde le indicaron antihistamínicos y aumento de la dosis de paracetamol, posterior a lo cual el cuadro se generalizó agregándose ampollas y áreas de piel denudada con afección sistémica. Debido a esto, fue hospitalizado en la unidad de cuidados intensivos pediátricos en donde se estableció el diagnóstico de síndrome de Stevens-Johnson, e inició tratamiento centrado en inmunoglobulina y esteroides con lo que tuvo mejoría clínica progresiva. CONCLUSIONES: Aunque la mayor parte de las reacciones de hipersensibilidad por fármacos se limita a reacciones cutáneas leves, es importante reconocer que aún los medicamentos aparentemente inocuos, como el paracetamol, pueden ser causa de reacciones secundarias severas, como el síndrome de Stevens-Johnson. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Dermatología Revista Mexicana is the property of Edicion y Farmacia S.A. de C.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.24245/dermatolrevmex.v65i6.7174 Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 8 StartPage: 991 Titles: – TitleFull: Síndrome de Stevens-Johnson inducido por paracetamol en un paciente pediátrico. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Alonso Rodríguez-Pinzón, Brandon – PersonEntity: Name: NameFull: Trejo-Chavira, Nohemi – PersonEntity: Name: NameFull: Alfaro-Sánchez, Abraham Benjamín – PersonEntity: Name: NameFull: Rodríguez-Cabral, Rebeca del C. – PersonEntity: Name: NameFull: González-Cabello, Diana IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov/Dec2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 01854038 Numbering: – Type: volume Value: 65 – Type: issue Value: 6 Titles: – TitleFull: Dermatología Revista Mexicana Type: main |
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