View in EDS PDF Full Text

Aflatoxin levels and prevalence of TP53 aflatoxin-mutations in hepatocellular carcinomas in Mexico.

Saved in:
Bibliographic Details
Title: Aflatoxin levels and prevalence of TP53 aflatoxin-mutations in hepatocellular carcinomas in Mexico.
Authors: Lino-Silva, Leonardo S.1, Lajous, Martín2,3, Brochier, Marion2, Santiago-Ruiz, Luis2, Melchor-Ruan, Javier4, Yi Xie5, Mingyi Wang6, Dongjing Wu6, Higson, Herbert6, Jones, Kristine6, Romero-Martínez, Martin7, Villalpando, Salvador8, Mohar, Alejandro9, Smith, Joshua W.10, Alvarez, Christian S.5, McGlynn, Katherine A.5, Dean, Michael5, Groopman, John10 mlajous@insp.mx
Source: Salud Pública de México. Jan/Feb2022, Vol. 64 Issue 1, p35-40. 6p.
Subjects: AFLATOXINS, HEPATOCELLULAR carcinoma, NUTRITION surveys, CANCER patients, GENETIC mutation, HEALTH surveys
Geographic Terms: MEXICO, CHIAPAS (Mexico)
Abstract (English): Objective. To determine the exposure to aflatoxin B1 (AFB1) in southern Mexico and the presence of the aflatoxin signature mutation in hepatocellular carcinoma (HCC) tissue from patients from a cancer referral center. Materials and methods. We estimated the prevalence and distribution of AFB1 in a representative sample of 100 women and men from Chiapas using the National Health and Nutrition Survey 2018-19. We also examined the presence of the aflatoxin signature mutation in codon 249 (R249S), and other relevant mutations of the TP53 gene in HCC tissue blocks from 24 women and 26 men treated in a national cancer referral center. Results. The prevalence of AFB1 in serum samples was 85.5% (95%CI 72.1-93.1) and the median AFB1 was 0.117 pg/μL (IQR, 0.050-0.350). We detected TP53 R249S in three of the 50 HCCs (6.0%) and observed four other G>T transversions potentially induced by AFB1. Conclusion. Our analysis provides evidence that AFB1 may have a relevant role on HCC etiology in Mexico. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Objetivo. Determinar la exposición a aflatoxina_B1 (AFB1) en el sur de México y la presencia de la mutación característica de AFB1 en tejido de carcinoma hepatocelular (CHC) de pacientes de un centro oncológico. Material y métodos. Se estimó la prevalencia y distribución de AFB1 en una muestra representativa de 100 mujeres y hombres de Chiapas a partir de la Encuesta Nacional de Salud y Nutrición 2018-19. También se observó la presencia de la mutación característica de AFB1 en el codón 249 (R249S), y otras mutaciones relevantes del gen TP53 en bloques de tejido de CHC de 24 mujeres y 26 hombres estudiados en un centro de referencia nacional de oncología. Resultados. La prevalencia de AFB1 en las muestras de suero fue de 85.5% (IC95% 72.1-93.1) y la mediana de la concentración 0.117 pg/μL (IQR, 0.050-0.350). Se detectó TP53 R249S en tres de 50 casos de CHC (6.0%) y se observaron cuatro transversiones G>T potencialmente inducidas por AFB1. Conclusión. El presente análisis proporciona evidencia de que la AFB1 puede tener un papel relevante en la etiología del CHC en México. [ABSTRACT FROM AUTHOR]
Copyright of Salud Pública de México is the property of Instituto Nacional de Salud Publica and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: lth
DbLabel: MedicLatina
An: 155616474
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Aflatoxin levels and prevalence of TP53 aflatoxin-mutations in hepatocellular carcinomas in Mexico.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Lino-Silva%2C+Leonardo+S%2E%22">Lino-Silva, Leonardo S.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lajous%2C+Martín%22">Lajous, Martín</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Brochier%2C+Marion%22">Brochier, Marion</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Santiago-Ruiz%2C+Luis%22">Santiago-Ruiz, Luis</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Melchor-Ruan%2C+Javier%22">Melchor-Ruan, Javier</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Yi+Xie%22">Yi Xie</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Mingyi+Wang%22">Mingyi Wang</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Dongjing+Wu%22">Dongjing Wu</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Higson%2C+Herbert%22">Higson, Herbert</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Jones%2C+Kristine%22">Jones, Kristine</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Romero-Martínez%2C+Martin%22">Romero-Martínez, Martin</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Villalpando%2C+Salvador%22">Villalpando, Salvador</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Mohar%2C+Alejandro%22">Mohar, Alejandro</searchLink><relatesTo>9</relatesTo><br /><searchLink fieldCode="AR" term="%22Smith%2C+Joshua+W%2E%22">Smith, Joshua W.</searchLink><relatesTo>10</relatesTo><br /><searchLink fieldCode="AR" term="%22Alvarez%2C+Christian+S%2E%22">Alvarez, Christian S.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22McGlynn%2C+Katherine+A%2E%22">McGlynn, Katherine A.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Dean%2C+Michael%22">Dean, Michael</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Groopman%2C+John%22">Groopman, John</searchLink><relatesTo>10</relatesTo><i> mlajous@insp.mx</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Salud+Pública+de+México%22">Salud Pública de México</searchLink>. Jan/Feb2022, Vol. 64 Issue 1, p35-40. 6p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22AFLATOXINS%22">AFLATOXINS</searchLink><br /><searchLink fieldCode="DE" term="%22HEPATOCELLULAR+carcinoma%22">HEPATOCELLULAR carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22NUTRITION+surveys%22">NUTRITION surveys</searchLink><br /><searchLink fieldCode="DE" term="%22CANCER+patients%22">CANCER patients</searchLink><br /><searchLink fieldCode="DE" term="%22GENETIC+mutation%22">GENETIC mutation</searchLink><br /><searchLink fieldCode="DE" term="%22HEALTH+surveys%22">HEALTH surveys</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22MEXICO%22">MEXICO</searchLink><br /><searchLink fieldCode="DE" term="%22CHIAPAS+%28Mexico%29%22">CHIAPAS (Mexico)</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Objective. To determine the exposure to aflatoxin B1 (AFB1) in southern Mexico and the presence of the aflatoxin signature mutation in hepatocellular carcinoma (HCC) tissue from patients from a cancer referral center. Materials and methods. We estimated the prevalence and distribution of AFB1 in a representative sample of 100 women and men from Chiapas using the National Health and Nutrition Survey 2018-19. We also examined the presence of the aflatoxin signature mutation in codon 249 (R249S), and other relevant mutations of the TP53 gene in HCC tissue blocks from 24 women and 26 men treated in a national cancer referral center. Results. The prevalence of AFB1 in serum samples was 85.5% (95%CI 72.1-93.1) and the median AFB1 was 0.117 pg/μL (IQR, 0.050-0.350). We detected TP53 R249S in three of the 50 HCCs (6.0%) and observed four other G>T transversions potentially induced by AFB1. Conclusion. Our analysis provides evidence that AFB1 may have a relevant role on HCC etiology in Mexico. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Objetivo. Determinar la exposición a aflatoxina_B1 (AFB1) en el sur de México y la presencia de la mutación característica de AFB1 en tejido de carcinoma hepatocelular (CHC) de pacientes de un centro oncológico. Material y métodos. Se estimó la prevalencia y distribución de AFB1 en una muestra representativa de 100 mujeres y hombres de Chiapas a partir de la Encuesta Nacional de Salud y Nutrición 2018-19. También se observó la presencia de la mutación característica de AFB1 en el codón 249 (R249S), y otras mutaciones relevantes del gen TP53 en bloques de tejido de CHC de 24 mujeres y 26 hombres estudiados en un centro de referencia nacional de oncología. Resultados. La prevalencia de AFB1 en las muestras de suero fue de 85.5% (IC95% 72.1-93.1) y la mediana de la concentración 0.117 pg/μL (IQR, 0.050-0.350). Se detectó TP53 R249S en tres de 50 casos de CHC (6.0%) y se observaron cuatro transversiones G>T potencialmente inducidas por AFB1. Conclusión. El presente análisis proporciona evidencia de que la AFB1 puede tener un papel relevante en la etiología del CHC en México. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Salud Pública de México is the property of Instituto Nacional de Salud Publica and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=155616474
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.21149/13189
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 35
    Subjects:
      – SubjectFull: AFLATOXINS
        Type: general
      – SubjectFull: HEPATOCELLULAR carcinoma
        Type: general
      – SubjectFull: NUTRITION surveys
        Type: general
      – SubjectFull: CANCER patients
        Type: general
      – SubjectFull: GENETIC mutation
        Type: general
      – SubjectFull: HEALTH surveys
        Type: general
      – SubjectFull: MEXICO
        Type: general
      – SubjectFull: CHIAPAS (Mexico)
        Type: general
    Titles:
      – TitleFull: Aflatoxin levels and prevalence of TP53 aflatoxin-mutations in hepatocellular carcinomas in Mexico.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Lino-Silva, Leonardo S.
      – PersonEntity:
          Name:
            NameFull: Lajous, Martín
      – PersonEntity:
          Name:
            NameFull: Brochier, Marion
      – PersonEntity:
          Name:
            NameFull: Santiago-Ruiz, Luis
      – PersonEntity:
          Name:
            NameFull: Melchor-Ruan, Javier
      – PersonEntity:
          Name:
            NameFull: Yi Xie
      – PersonEntity:
          Name:
            NameFull: Mingyi Wang
      – PersonEntity:
          Name:
            NameFull: Dongjing Wu
      – PersonEntity:
          Name:
            NameFull: Higson, Herbert
      – PersonEntity:
          Name:
            NameFull: Jones, Kristine
      – PersonEntity:
          Name:
            NameFull: Romero-Martínez, Martin
      – PersonEntity:
          Name:
            NameFull: Villalpando, Salvador
      – PersonEntity:
          Name:
            NameFull: Mohar, Alejandro
      – PersonEntity:
          Name:
            NameFull: Smith, Joshua W.
      – PersonEntity:
          Name:
            NameFull: Alvarez, Christian S.
      – PersonEntity:
          Name:
            NameFull: McGlynn, Katherine A.
      – PersonEntity:
          Name:
            NameFull: Dean, Michael
      – PersonEntity:
          Name:
            NameFull: Groopman, John
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: Jan/Feb2022
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-print
              Value: 00363634
          Numbering:
            – Type: volume
              Value: 64
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Salud Pública de México
              Type: main
ResultId 1