Urgent need for a rapid microbiological diagnosis in critically ill pneumonia.
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| Title: | Urgent need for a rapid microbiological diagnosis in critically ill pneumonia. |
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| Authors: | Martínez Sagasti, Fernando1 fmarsagasti@gmail.com, Calle Romero, María1, Rodríguez Gómez, Montserrat1, Alonso Martínez, Patricia1, Catalina García-Perrote, Sandra1 |
| Source: | Revista Española de Quimioterapia. 2022 Supplement, Vol. 35, p6-14. 9p. |
| Subjects: | MICROBIOLOGY, CRITICALLY ill patient care, ANTIBIOTICS, PATHOGENIC microorganisms, POLYMERASE chain reaction |
| Abstract: | Severe lower respiratory tract infection is a common issue in Intensive Care Units that causes significant morbidity and mortality. The traditional diagnostic-therapeutic approach has been grounded on taking respiratory samples and/or blood cultures as soon as possible and starting empirical antibiotic therapy addressed to cover most likely pathogens based on the presence of the patient's risk factors for certain microorganisms, while waiting for the culture results in the following 48-72 hours to adequate the antibiotic treatment to the sensitivity profile of the isolated pathogen. Unfortunately, this strategy leads to use broad-spectrum antibiotics more times than necessary and does not prevent possible therapeutic failures. The recent development of rapid molecular diagnostic techniques, based on real time polymerase chain reaction (RT-PCR), makes it possible to determine the causative agent and its main resistance pattern between 1 and 5 hours after sampling (depending on each technique), with high precision, some of them reaching a negative predictive value greater than 98%, facilitating the very early withdrawal of unnecessary broad-spectrum antibiotics. Its high sensitivity can also detect unsuspected pathogens based on risk factors, allowing adequate treatment in the first hours of stay. This short review discusses the potential usefulness of these techniques in critically ill patients with lower respiratory tract infection and advocates their immediate implementation in clinical practice. [ABSTRACT FROM AUTHOR] |
| Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
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| Header | DbId: lth DbLabel: MedicLatina An: 156575903 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Urgent need for a rapid microbiological diagnosis in critically ill pneumonia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Martínez+Sagasti%2C+Fernando%22">Martínez Sagasti, Fernando</searchLink><relatesTo>1</relatesTo><i> fmarsagasti@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Calle+Romero%2C+María%22">Calle Romero, María</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Rodríguez+Gómez%2C+Montserrat%22">Rodríguez Gómez, Montserrat</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Alonso+Martínez%2C+Patricia%22">Alonso Martínez, Patricia</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Catalina+García-Perrote%2C+Sandra%22">Catalina García-Perrote, Sandra</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Revista+Española+de+Quimioterapia%22">Revista Española de Quimioterapia</searchLink>. 2022 Supplement, Vol. 35, p6-14. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22MICROBIOLOGY%22">MICROBIOLOGY</searchLink><br /><searchLink fieldCode="DE" term="%22CRITICALLY+ill+patient+care%22">CRITICALLY ill patient care</searchLink><br /><searchLink fieldCode="DE" term="%22ANTIBIOTICS%22">ANTIBIOTICS</searchLink><br /><searchLink fieldCode="DE" term="%22PATHOGENIC+microorganisms%22">PATHOGENIC microorganisms</searchLink><br /><searchLink fieldCode="DE" term="%22POLYMERASE+chain+reaction%22">POLYMERASE chain reaction</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Severe lower respiratory tract infection is a common issue in Intensive Care Units that causes significant morbidity and mortality. The traditional diagnostic-therapeutic approach has been grounded on taking respiratory samples and/or blood cultures as soon as possible and starting empirical antibiotic therapy addressed to cover most likely pathogens based on the presence of the patient's risk factors for certain microorganisms, while waiting for the culture results in the following 48-72 hours to adequate the antibiotic treatment to the sensitivity profile of the isolated pathogen. Unfortunately, this strategy leads to use broad-spectrum antibiotics more times than necessary and does not prevent possible therapeutic failures. The recent development of rapid molecular diagnostic techniques, based on real time polymerase chain reaction (RT-PCR), makes it possible to determine the causative agent and its main resistance pattern between 1 and 5 hours after sampling (depending on each technique), with high precision, some of them reaching a negative predictive value greater than 98%, facilitating the very early withdrawal of unnecessary broad-spectrum antibiotics. Its high sensitivity can also detect unsuspected pathogens based on risk factors, allowing adequate treatment in the first hours of stay. This short review discusses the potential usefulness of these techniques in critically ill patients with lower respiratory tract infection and advocates their immediate implementation in clinical practice. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.37201/req/s01.02.2022 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 6 Subjects: – SubjectFull: MICROBIOLOGY Type: general – SubjectFull: CRITICALLY ill patient care Type: general – SubjectFull: ANTIBIOTICS Type: general – SubjectFull: PATHOGENIC microorganisms Type: general – SubjectFull: POLYMERASE chain reaction Type: general Titles: – TitleFull: Urgent need for a rapid microbiological diagnosis in critically ill pneumonia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Martínez Sagasti, Fernando – PersonEntity: Name: NameFull: Calle Romero, María – PersonEntity: Name: NameFull: Rodríguez Gómez, Montserrat – PersonEntity: Name: NameFull: Alonso Martínez, Patricia – PersonEntity: Name: NameFull: Catalina García-Perrote, Sandra IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 04 Text: 2022 Supplement Type: published Y: 2022 Identifiers: – Type: issn-print Value: 02143429 Numbering: – Type: volume Value: 35 Titles: – TitleFull: Revista Española de Quimioterapia Type: main |
| ResultId | 1 |
