A Chitosan-based Hydrogel with PLCL, ZnO NPs, and Oligoelements: A Promising Antibiotic Scaffold for Tissue Engineering.
Saved in:
| Title: | A Chitosan-based Hydrogel with PLCL, ZnO NPs, and Oligoelements: A Promising Antibiotic Scaffold for Tissue Engineering. |
|---|---|
| Alternate Title: | Hidrogel de Quitosano con PLCL, ZnO NPs y Oligoelementos: Un Andamio Antibacteriano Prometedor para Ingeniería de Tejidos. |
| Authors: | de los Ángeles Salinas Delgado, Yvain1, Sánchez, Stephanie Soria1, Esquivel Barajas, Gabriela Guadalupe1, Quiñonez, Eduardo Leos2, Bretado Aragón, Luis Alberto1 labretado@ucemich.edu.mx |
| Source: | Revista Mexicana de Ingeniería Biomédica. Jan-Apr2022, Vol. 43 Issue 1, p32-39. 8p. |
| Subjects: | TISSUE engineering, CELL proliferation, CHITOSAN, BACTERIAL diseases, ZINC oxide |
| Abstract (English): | Tissue engineering involves anchorage-dependent cells cultured on scaffolds, with growth factors added to facilitate cell proliferation. Its use in transplants implies the risk of bacterial infection. The current contribution describes the preparation and antibacterial evaluation of a chitosan-based hydrogel physically cross-linked with poly(l-lactic-co-ε-caprolactone) (PLCL) and enriched with zinc oxide nanoparticles (ZnO NPs) and trace elements (potassium and magnesium). The material was developed as a scaffold with built-in antibacterial properties. Chitosan and PLCL are biocompatible support materials applied in medicine for the repair and regeneration of damaged tissues, objectives promoted by ZnO NPs and the aforementioned trace elements. The ZnO NPs were elaborated by chemical coprecipitation. The materials were characterized by XRD, FT-IR, and SEM. Antibacterial testing was performed with strains of Escherichia coli and Staphylococcus aureus by the Kirby-Bauer method, in accordance with the NCCLS and CLSI guidelines. It was possible to obtain a homogeneous hydrogel with adequate morphology and distribution of elements. The hydrogel with 300 mM of Mg, K, and ZnO NP's showed antibacterial inhibition halos of 13 mm for S. aureus and 19 mm for E. coli. This innovative biomaterial with trace elements holds promise for tissue engineering by considering the challenge of bacterial infection. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | La ingeniería de tejidos involucra el uso de células cultivadas en andamios con adiciones de factores de crecimiento para facilitar la proliferación celular. Su uso en trasplantes implica riesgo de infección bacteriana. La contribución actual describe la preparación y evaluación antibacteriana de un hidrogel a base de quitosano físicamente reticulado con poli (l-láctico-co-ε-caprolactona) (PLCL) enriquecido con nanopartículas de óxido de zinc (NP de ZnO) y oligoelementos (potasio y magnesio). El material se desarrolló como un andamio con propiedades antibacterianas. El quitosano y el PLCL son materiales de soporte biocompatibles aplicados en medicina para la reparación y regeneración de tejidos dañados, propiedades promovidas por las NP´s de ZnO y los oligoelementos antes mencionados. Las NP de ZnO se elaboraron mediante coprecipitación química. Los materiales se caracterizaron por DRX, FT-IR y SEM. Las pruebas antibacterianas se realizaron con cepas de Escherichia coli y Staphylococcus aureus por el método de Kirby- Bauer de acuerdo con las guías NCCLS y CLSI. Se pudo obtener un hidrogel homogéneo con adecuada morfología y distribución de elementos. El hidrogel con 300 mM de NP ZnO y oligoelementos mostró halos de inhibición antibacteriana de 13 mm para S. aureus y 19 mm para E. coli. Este biomaterial innovador con oligoelementos es prometedor para la ingeniería de tejidos al considerar el desafío de la infección bacteriana. [ABSTRACT FROM AUTHOR] |
| Copyright of Revista Mexicana de Ingeniería Biomédica is the property of Sociedad Mexicana de Ingenieria Biomedica, A.C. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: lth DbLabel: MedicLatina An: 156958027 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: A Chitosan-based Hydrogel with PLCL, ZnO NPs, and Oligoelements: A Promising Antibiotic Scaffold for Tissue Engineering. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Hidrogel de Quitosano con PLCL, ZnO NPs y Oligoelementos: Un Andamio Antibacteriano Prometedor para Ingeniería de Tejidos. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22de+los+Ángeles+Salinas+Delgado%2C+Yvain%22">de los Ángeles Salinas Delgado, Yvain</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sánchez%2C+Stephanie+Soria%22">Sánchez, Stephanie Soria</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Esquivel+Barajas%2C+Gabriela+Guadalupe%22">Esquivel Barajas, Gabriela Guadalupe</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Quiñonez%2C+Eduardo+Leos%22">Quiñonez, Eduardo Leos</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Bretado+Aragón%2C+Luis+Alberto%22">Bretado Aragón, Luis Alberto</searchLink><relatesTo>1</relatesTo><i> labretado@ucemich.edu.mx</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Revista+Mexicana+de+Ingeniería+Biomédica%22">Revista Mexicana de Ingeniería Biomédica</searchLink>. Jan-Apr2022, Vol. 43 Issue 1, p32-39. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22TISSUE+engineering%22">TISSUE engineering</searchLink><br /><searchLink fieldCode="DE" term="%22CELL+proliferation%22">CELL proliferation</searchLink><br /><searchLink fieldCode="DE" term="%22CHITOSAN%22">CHITOSAN</searchLink><br /><searchLink fieldCode="DE" term="%22BACTERIAL+diseases%22">BACTERIAL diseases</searchLink><br /><searchLink fieldCode="DE" term="%22ZINC+oxide%22">ZINC oxide</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Tissue engineering involves anchorage-dependent cells cultured on scaffolds, with growth factors added to facilitate cell proliferation. Its use in transplants implies the risk of bacterial infection. The current contribution describes the preparation and antibacterial evaluation of a chitosan-based hydrogel physically cross-linked with poly(l-lactic-co-ε-caprolactone) (PLCL) and enriched with zinc oxide nanoparticles (ZnO NPs) and trace elements (potassium and magnesium). The material was developed as a scaffold with built-in antibacterial properties. Chitosan and PLCL are biocompatible support materials applied in medicine for the repair and regeneration of damaged tissues, objectives promoted by ZnO NPs and the aforementioned trace elements. The ZnO NPs were elaborated by chemical coprecipitation. The materials were characterized by XRD, FT-IR, and SEM. Antibacterial testing was performed with strains of Escherichia coli and Staphylococcus aureus by the Kirby-Bauer method, in accordance with the NCCLS and CLSI guidelines. It was possible to obtain a homogeneous hydrogel with adequate morphology and distribution of elements. The hydrogel with 300 mM of Mg, K, and ZnO NP's showed antibacterial inhibition halos of 13 mm for S. aureus and 19 mm for E. coli. This innovative biomaterial with trace elements holds promise for tissue engineering by considering the challenge of bacterial infection. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: La ingeniería de tejidos involucra el uso de células cultivadas en andamios con adiciones de factores de crecimiento para facilitar la proliferación celular. Su uso en trasplantes implica riesgo de infección bacteriana. La contribución actual describe la preparación y evaluación antibacteriana de un hidrogel a base de quitosano físicamente reticulado con poli (l-láctico-co-ε-caprolactona) (PLCL) enriquecido con nanopartículas de óxido de zinc (NP de ZnO) y oligoelementos (potasio y magnesio). El material se desarrolló como un andamio con propiedades antibacterianas. El quitosano y el PLCL son materiales de soporte biocompatibles aplicados en medicina para la reparación y regeneración de tejidos dañados, propiedades promovidas por las NP´s de ZnO y los oligoelementos antes mencionados. Las NP de ZnO se elaboraron mediante coprecipitación química. Los materiales se caracterizaron por DRX, FT-IR y SEM. Las pruebas antibacterianas se realizaron con cepas de Escherichia coli y Staphylococcus aureus por el método de Kirby- Bauer de acuerdo con las guías NCCLS y CLSI. Se pudo obtener un hidrogel homogéneo con adecuada morfología y distribución de elementos. El hidrogel con 300 mM de NP ZnO y oligoelementos mostró halos de inhibición antibacteriana de 13 mm para S. aureus y 19 mm para E. coli. Este biomaterial innovador con oligoelementos es prometedor para la ingeniería de tejidos al considerar el desafío de la infección bacteriana. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Revista Mexicana de Ingeniería Biomédica is the property of Sociedad Mexicana de Ingenieria Biomedica, A.C. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=156958027 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.17488/RMIB.43.1.3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 32 Subjects: – SubjectFull: TISSUE engineering Type: general – SubjectFull: CELL proliferation Type: general – SubjectFull: CHITOSAN Type: general – SubjectFull: BACTERIAL diseases Type: general – SubjectFull: ZINC oxide Type: general Titles: – TitleFull: A Chitosan-based Hydrogel with PLCL, ZnO NPs, and Oligoelements: A Promising Antibiotic Scaffold for Tissue Engineering. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: de los Ángeles Salinas Delgado, Yvain – PersonEntity: Name: NameFull: Sánchez, Stephanie Soria – PersonEntity: Name: NameFull: Esquivel Barajas, Gabriela Guadalupe – PersonEntity: Name: NameFull: Quiñonez, Eduardo Leos – PersonEntity: Name: NameFull: Bretado Aragón, Luis Alberto IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan-Apr2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 01889532 Numbering: – Type: volume Value: 43 – Type: issue Value: 1 Titles: – TitleFull: Revista Mexicana de Ingeniería Biomédica Type: main |
| ResultId | 1 |
