Relojes circadianos y ayuno prolongado: potencial terapéutico en el tratamiento de las enfermedades metabólicas.
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| Title: | Relojes circadianos y ayuno prolongado: potencial terapéutico en el tratamiento de las enfermedades metabólicas. |
|---|---|
| Alternate Title: | Circadian clocks and prolonged fasting: Therapeutic potential in the treatment of metabolic diseases. |
| Authors: | Fernández-De La Torre, María1, Hernández-Díaz, Paola1, Aspe-Viñolas, Julio1, Ahumada-Ayala, Miguel1,2 ahumadam1@hotmail.com |
| Source: | Medicina Interna de México. may/jun2022, Vol. 38 Issue 3, p649-664. 16p. |
| Abstract (English): | Circadian rhythms are biological phenomena, occurring in almost all living species, which are cyclically repeated every 24 hours, in synchrony with earth rotation. They provide rhythmicity to many physiological functions and make it possible to anticipate the most appropriate metabolic response to recurrent events, while maintaining homeostasis. Circadian rhythms are controlled by sophisticated intracellular molecular mechanisms. The central or master clock is located in the suprachiasmatic nuclei and it is synchronized with the peripheral clocks located in most other tissues. There are external clues or zeitgebers, that allow the synchronization and harmony of circadian clocks. The main zeitgeber of the central clock are the light-dark periods. While the composition and schedule of the diet, sleep periods, and physical activity are zeitgebers acting mainly on peripheral clocks. Modern lifestyle characterized by increased use of electronic screens emitting blue-light, night-time working shifts, high-fat diets, and irregular eating patterns may directly interfere with the harmonious functioning of circadian clocks. Chronic circadian desynchrony is possibly involved in the pathogenesis of metabolic diseases such as type 2 diabetes mellitus, systemic hypertension, metabolic syndrome and obesity. Prolonged nocturnal fasting can be used as a tool for adjusting circadian clocks, a reduced feeding-time window with regular caloric intake allow a timely metabolic response which is in synchrony with circadian genes. Aligning of circadian clocks represents a potential ancillary method for preventing and treating metabolic diseases. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Los ritmos circadianos son fenómenos biológicos que se repiten de forma cíclica cada 24 horas, en sincronía con el movimiento rotatorio de la Tierra. Son responsables de la armonía de diversas funciones fisiológicas y permiten conservar la homeostasia anticipando la respuesta metabólica ante diversos eventos recurrentes. Los osciladores circadianos son regulados por mecanismos genéticos intracelulares. El reloj circadiano central se encuentra en los núcleos supraquiasmáticos del hipotálamo y está en sincronía con los relojes circadianos periféricos, localizados en el resto de los tejidos. Existen señales externas denominadas gatillos o zeitgebers, que permiten la sincronización y armonía de los relojes circadianos. El zeitgeber principal del reloj central es la alternancia de los periodos de luz/oscuridad. Mientras que el horario y composición de los alimentos, los periodos de sueño y la actividad física son zeitgebers con acción predominante sobre los relojes periféricos. El estilo de vida moderno, con el incremento del uso de las pantallas electrónicas emisoras de luz azul, los horarios laborales nocturnos, las dietas altas en grasa y los patrones irregulares en los horarios de alimentación puede interferir con la correcta alineación de los relojes circadianos. La desincronía circadiana crónica participa en la patogénesis de las enfermedades metabólicas, como la diabetes mellitus tipo 2, la hipertensión arterial sistémica, el síndrome metabólico y la obesidad. El ayuno nocturno prolongado es una herramienta para ajustar los relojes circadianos. Una ventana de alimentación reducida, con periodos de ingesta calórica regular, permite una respuesta metabólica oportuna en óptima sincronía con los relojes circadianos. El alineamiento de los relojes circadianos es un instrumento coadyuvante potencial para prevenir y tratar las enfermedades metabólicas. [ABSTRACT FROM AUTHOR] |
| Copyright of Medicina Interna de México is the property of Colegio de Medicina Interna de Mexico and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Relojes circadianos y ayuno prolongado: potencial terapéutico en el tratamiento de las enfermedades metabólicas. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Circadian clocks and prolonged fasting: Therapeutic potential in the treatment of metabolic diseases. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fernández-De+La+Torre%2C+María%22">Fernández-De La Torre, María</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hernández-Díaz%2C+Paola%22">Hernández-Díaz, Paola</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Aspe-Viñolas%2C+Julio%22">Aspe-Viñolas, Julio</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ahumada-Ayala%2C+Miguel%22">Ahumada-Ayala, Miguel</searchLink><relatesTo>1,2</relatesTo><i> ahumadam1@hotmail.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Medicina+Interna+de+México%22">Medicina Interna de México</searchLink>. may/jun2022, Vol. 38 Issue 3, p649-664. 16p. – Name: Abstract Label: Abstract (English) Group: Ab Data: Circadian rhythms are biological phenomena, occurring in almost all living species, which are cyclically repeated every 24 hours, in synchrony with earth rotation. They provide rhythmicity to many physiological functions and make it possible to anticipate the most appropriate metabolic response to recurrent events, while maintaining homeostasis. Circadian rhythms are controlled by sophisticated intracellular molecular mechanisms. The central or master clock is located in the suprachiasmatic nuclei and it is synchronized with the peripheral clocks located in most other tissues. There are external clues or zeitgebers, that allow the synchronization and harmony of circadian clocks. The main zeitgeber of the central clock are the light-dark periods. While the composition and schedule of the diet, sleep periods, and physical activity are zeitgebers acting mainly on peripheral clocks. Modern lifestyle characterized by increased use of electronic screens emitting blue-light, night-time working shifts, high-fat diets, and irregular eating patterns may directly interfere with the harmonious functioning of circadian clocks. Chronic circadian desynchrony is possibly involved in the pathogenesis of metabolic diseases such as type 2 diabetes mellitus, systemic hypertension, metabolic syndrome and obesity. Prolonged nocturnal fasting can be used as a tool for adjusting circadian clocks, a reduced feeding-time window with regular caloric intake allow a timely metabolic response which is in synchrony with circadian genes. Aligning of circadian clocks represents a potential ancillary method for preventing and treating metabolic diseases. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Los ritmos circadianos son fenómenos biológicos que se repiten de forma cíclica cada 24 horas, en sincronía con el movimiento rotatorio de la Tierra. Son responsables de la armonía de diversas funciones fisiológicas y permiten conservar la homeostasia anticipando la respuesta metabólica ante diversos eventos recurrentes. Los osciladores circadianos son regulados por mecanismos genéticos intracelulares. El reloj circadiano central se encuentra en los núcleos supraquiasmáticos del hipotálamo y está en sincronía con los relojes circadianos periféricos, localizados en el resto de los tejidos. Existen señales externas denominadas gatillos o zeitgebers, que permiten la sincronización y armonía de los relojes circadianos. El zeitgeber principal del reloj central es la alternancia de los periodos de luz/oscuridad. Mientras que el horario y composición de los alimentos, los periodos de sueño y la actividad física son zeitgebers con acción predominante sobre los relojes periféricos. El estilo de vida moderno, con el incremento del uso de las pantallas electrónicas emisoras de luz azul, los horarios laborales nocturnos, las dietas altas en grasa y los patrones irregulares en los horarios de alimentación puede interferir con la correcta alineación de los relojes circadianos. La desincronía circadiana crónica participa en la patogénesis de las enfermedades metabólicas, como la diabetes mellitus tipo 2, la hipertensión arterial sistémica, el síndrome metabólico y la obesidad. El ayuno nocturno prolongado es una herramienta para ajustar los relojes circadianos. Una ventana de alimentación reducida, con periodos de ingesta calórica regular, permite una respuesta metabólica oportuna en óptima sincronía con los relojes circadianos. El alineamiento de los relojes circadianos es un instrumento coadyuvante potencial para prevenir y tratar las enfermedades metabólicas. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Medicina Interna de México is the property of Colegio de Medicina Interna de Mexico and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.24245/mim.v38i3.7079 Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 16 StartPage: 649 Titles: – TitleFull: Relojes circadianos y ayuno prolongado: potencial terapéutico en el tratamiento de las enfermedades metabólicas. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fernández-De La Torre, María – PersonEntity: Name: NameFull: Hernández-Díaz, Paola – PersonEntity: Name: NameFull: Aspe-Viñolas, Julio – PersonEntity: Name: NameFull: Ahumada-Ayala, Miguel IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: may/jun2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 01864866 Numbering: – Type: volume Value: 38 – Type: issue Value: 3 Titles: – TitleFull: Medicina Interna de México Type: main |
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