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Acute myocarditis after administering the BNT162b2 (Pfizer-BioNTech) vaccine against COVID-19 in an adolescent patient.

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Title: Acute myocarditis after administering the BNT162b2 (Pfizer-BioNTech) vaccine against COVID-19 in an adolescent patient.
Alternate Title: Miocarditis aguda tras la administración de la vacuna BNT162b2 (Pfizer-BioNTech) contra COVID-19 en un paciente adolescente.
Authors: Isaí López-Martínez, Samuel1 dr-samuel.lopez@outlook.com, Nicéforo Monroy-Sánchez, Edgar2, Alejandro Solís-Reyna, Rodrigo3, Vanesa Pasos-Caamal, Monica4, Jesús Onofre-Castillo, Javier5
Source: Cardiovascular & Metabolic Science. Jul-Sep2022, Vol. 33 Issue 3, p118-122. 5p.
Subjects: MYOCARDITIS, COVID-19 pandemic, VACCINES, PFIZER Inc., ELECTROCARDIOGRAPHY
Abstract (English): Myocarditis is a multifactorial inflammatory condition of the myocardium. Recently myocarditis has been recognized as an adverse event in patients vaccinated against COVID-19 with Pfizer-BioNTech and Moderna (mRNA vaccines), mainly in adolescents and young adults. Cardiac magnetic resonance (CMR) allows the characterization of myocardial tissue and cardiac function and has become the non-invasive diagnostic gold standard in patients with suspected acute myocarditis. The authors present a 16-year-old male case with stabbing chest pain after the second dose of immunization against SARS-CoV-2 with the BNT162B2 (Pfizer-BioNTech) vaccine. The electrocardiogram (ECG) showed disclosed ST-segment elevation, and increased myocardial injury markers were also observed. Angio tomography (AngioCT) showed subtle signs of myocardial hypoperfusion and left ventricular dysfunction. Gadolinium CMR was performed, identifying global hypokinesis of the left ventricle (LV), myocardial edema hyperemia and late gadolinium enhancement (LGE) as evidence of myocardial injury, and markers of non-ischemic intramyocardial inflammatory lesion. Having excluded other etiologies, this presentation of acute myocarditis is proposed to be an adverse reaction associated with the BNT162b2 vaccine against COVID-19. The long-term risks of the COVID-19 vaccine in children, adolescents and young adults are still unknown, and further investigation will be needed. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): La miocarditis es una condición inflamatoria multifactorial del miocardio. La miocarditis ha sido reconocida recientemente como un evento adverso, en pacientes vacunados contra COVID-19 con Pfizer-BioNTech y Moderna (vacunas de ARNm), principalmente en adolescentes y adultos jóvenes. La resonancia magnética cardiaca (RMC) permite caracterizar el tejido miocárdico y la función cardiaca y se ha convertido en el estándar de oro no-invasivo en pacientes con sospecha de miocarditis aguda. Los autores presentan a un paciente masculino de 16 años con dolor torácico punzante tras la segunda dosis de inmunización contra el SARS-CoV-2 con la vacuna BNT162B2 (Pfizer-BioNTech). El electrocardiograma (ECG) mostró elevación del segmento ST y aumento de los biomarcadores de lesión miocárdica. La angiotomografía (AngioTC) mostró signos sutiles de hipoperfusión miocárdica y disfunción ventricular izquierda. Se realizó RMC con gadolinio, identificando hipocinesia global del ventrículo izquierdo (VI), hiperemia por edema miocárdico y realce tardío de gadolinio (RTG) como evidencia de lesión miocárdica y marcadores de lesión inflamatoria intramiocárdica no-isquémica. Habiendo excluido otras etiologías, se propone que esta presentación de miocarditis aguda sea una reacción adversa asociada a la vacuna BNT162b2 contra COVID-19. Los riesgos a largo plazo de la vacuna contra la COVID-19 en niños, adolescentes y adultos jóvenes aún se desconocen, por lo que será necesario seguir investigando. [ABSTRACT FROM AUTHOR]
Copyright of Cardiovascular & Metabolic Science is the property of Cardiovascular & Metabolic Science, Asociacion Nacional de Cardiologos de Mexico A.C. (ANCAM) and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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  Data: Acute myocarditis after administering the BNT162b2 (Pfizer-BioNTech) vaccine against COVID-19 in an adolescent patient.
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  Data: Miocarditis aguda tras la administración de la vacuna BNT162b2 (Pfizer-BioNTech) contra COVID-19 en un paciente adolescente.
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  Data: <searchLink fieldCode="AR" term="%22Isaí+López-Martínez%2C+Samuel%22">Isaí López-Martínez, Samuel</searchLink><relatesTo>1</relatesTo><i> dr-samuel.lopez@outlook.com</i><br /><searchLink fieldCode="AR" term="%22Nicéforo+Monroy-Sánchez%2C+Edgar%22">Nicéforo Monroy-Sánchez, Edgar</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Alejandro+Solís-Reyna%2C+Rodrigo%22">Alejandro Solís-Reyna, Rodrigo</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Vanesa+Pasos-Caamal%2C+Monica%22">Vanesa Pasos-Caamal, Monica</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Jesús+Onofre-Castillo%2C+Javier%22">Jesús Onofre-Castillo, Javier</searchLink><relatesTo>5</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Cardiovascular+%26+Metabolic+Science%22">Cardiovascular & Metabolic Science</searchLink>. Jul-Sep2022, Vol. 33 Issue 3, p118-122. 5p.
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– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Myocarditis is a multifactorial inflammatory condition of the myocardium. Recently myocarditis has been recognized as an adverse event in patients vaccinated against COVID-19 with Pfizer-BioNTech and Moderna (mRNA vaccines), mainly in adolescents and young adults. Cardiac magnetic resonance (CMR) allows the characterization of myocardial tissue and cardiac function and has become the non-invasive diagnostic gold standard in patients with suspected acute myocarditis. The authors present a 16-year-old male case with stabbing chest pain after the second dose of immunization against SARS-CoV-2 with the BNT162B2 (Pfizer-BioNTech) vaccine. The electrocardiogram (ECG) showed disclosed ST-segment elevation, and increased myocardial injury markers were also observed. Angio tomography (AngioCT) showed subtle signs of myocardial hypoperfusion and left ventricular dysfunction. Gadolinium CMR was performed, identifying global hypokinesis of the left ventricle (LV), myocardial edema hyperemia and late gadolinium enhancement (LGE) as evidence of myocardial injury, and markers of non-ischemic intramyocardial inflammatory lesion. Having excluded other etiologies, this presentation of acute myocarditis is proposed to be an adverse reaction associated with the BNT162b2 vaccine against COVID-19. The long-term risks of the COVID-19 vaccine in children, adolescents and young adults are still unknown, and further investigation will be needed. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: La miocarditis es una condición inflamatoria multifactorial del miocardio. La miocarditis ha sido reconocida recientemente como un evento adverso, en pacientes vacunados contra COVID-19 con Pfizer-BioNTech y Moderna (vacunas de ARNm), principalmente en adolescentes y adultos jóvenes. La resonancia magnética cardiaca (RMC) permite caracterizar el tejido miocárdico y la función cardiaca y se ha convertido en el estándar de oro no-invasivo en pacientes con sospecha de miocarditis aguda. Los autores presentan a un paciente masculino de 16 años con dolor torácico punzante tras la segunda dosis de inmunización contra el SARS-CoV-2 con la vacuna BNT162B2 (Pfizer-BioNTech). El electrocardiograma (ECG) mostró elevación del segmento ST y aumento de los biomarcadores de lesión miocárdica. La angiotomografía (AngioTC) mostró signos sutiles de hipoperfusión miocárdica y disfunción ventricular izquierda. Se realizó RMC con gadolinio, identificando hipocinesia global del ventrículo izquierdo (VI), hiperemia por edema miocárdico y realce tardío de gadolinio (RTG) como evidencia de lesión miocárdica y marcadores de lesión inflamatoria intramiocárdica no-isquémica. Habiendo excluido otras etiologías, se propone que esta presentación de miocarditis aguda sea una reacción adversa asociada a la vacuna BNT162b2 contra COVID-19. Los riesgos a largo plazo de la vacuna contra la COVID-19 en niños, adolescentes y adultos jóvenes aún se desconocen, por lo que será necesario seguir investigando. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Cardiovascular & Metabolic Science is the property of Cardiovascular & Metabolic Science, Asociacion Nacional de Cardiologos de Mexico A.C. (ANCAM) and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=160604007
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        Value: 10.35366/107625
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        Text: English
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        Type: general
      – SubjectFull: COVID-19 pandemic
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      – SubjectFull: VACCINES
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      – SubjectFull: PFIZER Inc.
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      – SubjectFull: ELECTROCARDIOGRAPHY
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      – TitleFull: Acute myocarditis after administering the BNT162b2 (Pfizer-BioNTech) vaccine against COVID-19 in an adolescent patient.
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              Text: Jul-Sep2022
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