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Current enzyme-mediated insecticide resistance status of Aedes aegypti populations from a dengue-endemic city in southern Mexico.

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Title: Current enzyme-mediated insecticide resistance status of Aedes aegypti populations from a dengue-endemic city in southern Mexico.
Alternate Title: Estado actual de la resistencia a insecticidas mediada por enzimas en poblaciones de Aedes aegypti de una ciudad endémica de dengue en el sur de México.
Authors: Solís-Santoyo, Francisco1,2, Rodríguez, Américo D.1, Black, William3, Saavedra-Rodríguez, Karla3, Sánchez-Guillén, Daniel2, Castillo-Vera, Alfredo2, González-Gómez, Rebeca2, Delia López-Solis, Alma1,2, Patricia Penilla-Navarro, Rosa1 penilla@insp.mx
Source: Salud Pública de México. Jan/Feb2023, Vol. 65 Issue 1, p19-27. 9p.
Subjects: AEDES aegypti, INSECTICIDE resistance, MOSQUITOES, PYRETHROIDS, CHOLINESTERASE reactivators, MALATHION, CYPERMETHRIN
Geographic Terms: MEXICO
Abstract (English): Objective. To identify the enzyme-mediated insecticide resistance in Aedes aegypti in Tapachula, Mexico. Materials and methods. Biochemical assays were undertaken to determine the enzyme levels in mosquitoes from 22 sites collected in 2018 and 2020 in Tapachula. Results of 2018 were correlated with the resistance to insecticides published. Results. Mosquitoes had higher levels than those of the susceptible strain in 2018 and 2020 respectively of a-esterases in 15 and 12 sites; ß-esterases in 7 and 6 sites; glutathione-S-transferases in 11 and 19 sites; ρNPA-esterases in 21 and 17 sites; and cytochromes P450 in 20 and 22 sites. In mosquitoes of 2018, there was a moderate correlation between previously documented Malathion resistance ratios and the insensitive acetylcholinesterase (r=0.459, p= 0.03). Conclusions. The elevated enzyme levels found indicate its contribution to the resistance to pyrethroids and organophosphates already published in mosquitoes from Tapachula. Bioassays using enzyme inhibitors resulted in greater mortality, confirming that metabolism contributes to resistance. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Objetivo. Identificar la resistencia a insecticidas mediada por enzimas en Aedes aegypti de Tapachula, México. Material y métodos. Se realizaron ensayos bioquímicos para calcular los niveles enzimáticos en mosquitos de 22 sitios colectados en Tapachula en 2018 y 2020. Resultados de 2018 se correlacionaron con la resistencia a insecticidas publicada. Resultados. Se obtuvieron niveles más altos que los de la cepa susceptible en 2018 y 2020, respectivamente, de: a-esterasas en 15 y 12 sitios; ß-esterasas en 7 y 6 sitios; glutatión-S-transferasas en 11 y 19 sitios; ρNPA-esterases en 21 y 17 sitios; y citocromos P450 en 20 y 22 sitios. Los índices publicados de resistencia al malatión y la acetilcolinesterasa insensible tuvieron una correlación moderada (r=0.459, p= 0.03) en mosquitos de 2018. Conclusiones. Los altos niveles enzimáticos encontrados indican su contribución en la resistencia a piretroides y organofosforados en mosquitos de Tapachula de 2018. Bioensayos con inhibidores enzimáticos dieron mayores mortalidades, confirmando que el metabolismo contribuye en la resistencia. [ABSTRACT FROM AUTHOR]
Copyright of Salud Pública de México is the property of Instituto Nacional de Salud Publica and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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DbLabel: MedicLatina
An: 162217704
AccessLevel: 6
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Current enzyme-mediated insecticide resistance status of Aedes aegypti populations from a dengue-endemic city in southern Mexico.
– Name: TitleAlt
  Label: Alternate Title
  Group: TiAlt
  Data: Estado actual de la resistencia a insecticidas mediada por enzimas en poblaciones de Aedes aegypti de una ciudad endémica de dengue en el sur de México.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Solís-Santoyo%2C+Francisco%22">Solís-Santoyo, Francisco</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Rodríguez%2C+Américo+D%2E%22">Rodríguez, Américo D.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Black%2C+William%22">Black, William</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Saavedra-Rodríguez%2C+Karla%22">Saavedra-Rodríguez, Karla</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Sánchez-Guillén%2C+Daniel%22">Sánchez-Guillén, Daniel</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Castillo-Vera%2C+Alfredo%22">Castillo-Vera, Alfredo</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22González-Gómez%2C+Rebeca%22">González-Gómez, Rebeca</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Delia+López-Solis%2C+Alma%22">Delia López-Solis, Alma</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Patricia+Penilla-Navarro%2C+Rosa%22">Patricia Penilla-Navarro, Rosa</searchLink><relatesTo>1</relatesTo><i> penilla@insp.mx</i>
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  Data: <searchLink fieldCode="JN" term="%22Salud+Pública+de+México%22">Salud Pública de México</searchLink>. Jan/Feb2023, Vol. 65 Issue 1, p19-27. 9p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22AEDES+aegypti%22">AEDES aegypti</searchLink><br /><searchLink fieldCode="DE" term="%22INSECTICIDE+resistance%22">INSECTICIDE resistance</searchLink><br /><searchLink fieldCode="DE" term="%22MOSQUITOES%22">MOSQUITOES</searchLink><br /><searchLink fieldCode="DE" term="%22PYRETHROIDS%22">PYRETHROIDS</searchLink><br /><searchLink fieldCode="DE" term="%22CHOLINESTERASE+reactivators%22">CHOLINESTERASE reactivators</searchLink><br /><searchLink fieldCode="DE" term="%22MALATHION%22">MALATHION</searchLink><br /><searchLink fieldCode="DE" term="%22CYPERMETHRIN%22">CYPERMETHRIN</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22MEXICO%22">MEXICO</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Objective. To identify the enzyme-mediated insecticide resistance in Aedes aegypti in Tapachula, Mexico. Materials and methods. Biochemical assays were undertaken to determine the enzyme levels in mosquitoes from 22 sites collected in 2018 and 2020 in Tapachula. Results of 2018 were correlated with the resistance to insecticides published. Results. Mosquitoes had higher levels than those of the susceptible strain in 2018 and 2020 respectively of a-esterases in 15 and 12 sites; ß-esterases in 7 and 6 sites; glutathione-S-transferases in 11 and 19 sites; ρNPA-esterases in 21 and 17 sites; and cytochromes P450 in 20 and 22 sites. In mosquitoes of 2018, there was a moderate correlation between previously documented Malathion resistance ratios and the insensitive acetylcholinesterase (r=0.459, p= 0.03). Conclusions. The elevated enzyme levels found indicate its contribution to the resistance to pyrethroids and organophosphates already published in mosquitoes from Tapachula. Bioassays using enzyme inhibitors resulted in greater mortality, confirming that metabolism contributes to resistance. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Objetivo. Identificar la resistencia a insecticidas mediada por enzimas en Aedes aegypti de Tapachula, México. Material y métodos. Se realizaron ensayos bioquímicos para calcular los niveles enzimáticos en mosquitos de 22 sitios colectados en Tapachula en 2018 y 2020. Resultados de 2018 se correlacionaron con la resistencia a insecticidas publicada. Resultados. Se obtuvieron niveles más altos que los de la cepa susceptible en 2018 y 2020, respectivamente, de: a-esterasas en 15 y 12 sitios; ß-esterasas en 7 y 6 sitios; glutatión-S-transferasas en 11 y 19 sitios; ρNPA-esterases en 21 y 17 sitios; y citocromos P450 en 20 y 22 sitios. Los índices publicados de resistencia al malatión y la acetilcolinesterasa insensible tuvieron una correlación moderada (r=0.459, p= 0.03) en mosquitos de 2018. Conclusiones. Los altos niveles enzimáticos encontrados indican su contribución en la resistencia a piretroides y organofosforados en mosquitos de Tapachula de 2018. Bioensayos con inhibidores enzimáticos dieron mayores mortalidades, confirmando que el metabolismo contribuye en la resistencia. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Salud Pública de México is the property of Instituto Nacional de Salud Publica and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=162217704
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      – Type: doi
        Value: 10.21149/13910
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 9
        StartPage: 19
    Subjects:
      – SubjectFull: AEDES aegypti
        Type: general
      – SubjectFull: INSECTICIDE resistance
        Type: general
      – SubjectFull: MOSQUITOES
        Type: general
      – SubjectFull: PYRETHROIDS
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      – SubjectFull: CHOLINESTERASE reactivators
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      – SubjectFull: MALATHION
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      – SubjectFull: CYPERMETHRIN
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      – SubjectFull: MEXICO
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      – TitleFull: Current enzyme-mediated insecticide resistance status of Aedes aegypti populations from a dengue-endemic city in southern Mexico.
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              Text: Jan/Feb2023
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