Síndrome urémico hemolítico atípico por identificación de C3 por estudio genético. Reporte de caso.
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| Title: | Síndrome urémico hemolítico atípico por identificación de C3 por estudio genético. Reporte de caso. |
|---|---|
| Alternate Title: | Atypical Hemolytic Uremic Syndrome by identification of C3 by genetic study. Case report. |
| Authors: | Flores Salazar, Heriberto Sebastián1 sebastianfloressalazar@gmail.com, Cruz Aquino, David2, Frías Mendívil, Mauricio3 |
| Source: | Boletín Clínico Hospital Infantil del Estado de Sonora. abr2023, Vol. 40 Issue 1, p36-39. 4p. |
| Abstract (English): | The atypical Hemolytic Uremic Syndrome (aHUS) is a rare variant of a TMA caused by an abnormality in alternative complement pathway, resulting in an endothelial dysfunction producing thrombus formation at the level of the microvasculature. It is considered as an atypical HUS since it is not caused by any of the common etiologies of classic HUS (shyga toxin produced by E. coli O157:H7 or S. dysenteriae). The genetic alterations or acquired dysregulations of the alternative complement pathway result in 40%-60% of aHUS causes, suggesting a high genetic predisposition. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | El Síndrome Hemolítico Urémico atípico (SHUa) es una variante rara de una tromboangiopatía, causada por anormalidades en la vía alterna del complemento. Da como resultado disfunción renal a nivel endotelial, que produce formación de trombos en la microvasculatura. Se considera como SHU atípico, ya que éste no es causado por ninguna de las etiologías comunes del SHU clásico (toxina Shiga producida por E. coli O157:H7 o S. dysenteriae). Las alteraciones genéticas o las disrregulaciones adquiridas de la vía alterna del complemento, resultan entre el 40%-60% de las causas de SHUa, lo que sugiere una alta predisposición genética. [ABSTRACT FROM AUTHOR] |
| Copyright of Boletín Clínico Hospital Infantil del Estado de Sonora is the property of Asociacion Medica del Hospital Infantil del Estado de Sonora A.C. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 164390798 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Síndrome urémico hemolítico atípico por identificación de C3 por estudio genético. Reporte de caso. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Atypical Hemolytic Uremic Syndrome by identification of C3 by genetic study. Case report. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Flores+Salazar%2C+Heriberto+Sebastián%22">Flores Salazar, Heriberto Sebastián</searchLink><relatesTo>1</relatesTo><i> sebastianfloressalazar@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Cruz+Aquino%2C+David%22">Cruz Aquino, David</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Frías+Mendívil%2C+Mauricio%22">Frías Mendívil, Mauricio</searchLink><relatesTo>3</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Boletín+Clínico+Hospital+Infantil+del+Estado+de+Sonora%22">Boletín Clínico Hospital Infantil del Estado de Sonora</searchLink>. abr2023, Vol. 40 Issue 1, p36-39. 4p. – Name: Abstract Label: Abstract (English) Group: Ab Data: The atypical Hemolytic Uremic Syndrome (aHUS) is a rare variant of a TMA caused by an abnormality in alternative complement pathway, resulting in an endothelial dysfunction producing thrombus formation at the level of the microvasculature. It is considered as an atypical HUS since it is not caused by any of the common etiologies of classic HUS (shyga toxin produced by E. coli O157:H7 or S. dysenteriae). The genetic alterations or acquired dysregulations of the alternative complement pathway result in 40%-60% of aHUS causes, suggesting a high genetic predisposition. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: El Síndrome Hemolítico Urémico atípico (SHUa) es una variante rara de una tromboangiopatía, causada por anormalidades en la vía alterna del complemento. Da como resultado disfunción renal a nivel endotelial, que produce formación de trombos en la microvasculatura. Se considera como SHU atípico, ya que éste no es causado por ninguna de las etiologías comunes del SHU clásico (toxina Shiga producida por E. coli O157:H7 o S. dysenteriae). Las alteraciones genéticas o las disrregulaciones adquiridas de la vía alterna del complemento, resultan entre el 40%-60% de las causas de SHUa, lo que sugiere una alta predisposición genética. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Boletín Clínico Hospital Infantil del Estado de Sonora is the property of Asociacion Medica del Hospital Infantil del Estado de Sonora A.C. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=164390798 |
| RecordInfo | BibRecord: BibEntity: Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 4 StartPage: 36 Titles: – TitleFull: Síndrome urémico hemolítico atípico por identificación de C3 por estudio genético. Reporte de caso. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Flores Salazar, Heriberto Sebastián – PersonEntity: Name: NameFull: Cruz Aquino, David – PersonEntity: Name: NameFull: Frías Mendívil, Mauricio IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: abr2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 14051303 Numbering: – Type: volume Value: 40 – Type: issue Value: 1 Titles: – TitleFull: Boletín Clínico Hospital Infantil del Estado de Sonora Type: main |
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