GENETIC VARIANTS IN GHRELIN AND LEPTIN ARE ASSOCIATED WITH APPETITIVE TRAITS BUT NOT WITH BODY COMPOSITION PARAMETERS IN YOUNG ADULTS FROM WESTERN MEXICO.
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| Title: | GENETIC VARIANTS IN GHRELIN AND LEPTIN ARE ASSOCIATED WITH APPETITIVE TRAITS BUT NOT WITH BODY COMPOSITION PARAMETERS IN YOUNG ADULTS FROM WESTERN MEXICO. |
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| Authors: | Espinoza García, Astrid Selene1, Díaz Chávez, Rosa Lilian1, Parra Rojas, Isela2, Valdés Miramontes, Elia Herminia1, Reyes-Castillo, Zyanya1 |
| Source: | Archivos Latinoamericanos de Nutrición. 2023 Suppl 1, Vol. 73, p175-175. 1/2p. |
| Subjects: | YOUNG adults, GENETIC variation, GHRELIN, FOOD fussiness, GHRELIN receptors, POLYACRYLAMIDE gel electrophoresis, BODY composition |
| Geographic Terms: | MEXICO |
| Abstract: | Introduction. Obesity is a complex condition influenced by interactions between environmental, behavioral, and genetic factors. Several genes are involved in appetite regulation, such as ghrelin (GHRL) and leptin (LEP). Variants in these genes have been linked to metabolic effects and appetite through eating behaviors via the Behavioral Susceptibility Theory (BST). Purpose. This study aimed to evaluate the association of genetic variants at GHRL (rs27647 and rs696217) and LEP genes (rs7799039), with body composition parameters and explore possible associations with appetitive traits in young adults from western Mexico. Methods. Blood samples were obtained, and parameters of body composition were measured by bioelectrical impedance. Amplification and genotyping of rs27647, rs696217 and rs7799039 were performed with PCR-RFLP technique (using BsrI, DraI and BhaI enzymes, respectively) and visualized with polyacrylamide gel electrophoresis technique. Appetitive traits were assessed via the Adult Eating Behaviour Questionnaire, which comprises 'food approach' subscales: Food Responsiveness (FR), Enjoyment of Food (EF) and Emotional Over-eating (EOE) and 'food avoidance' subscales: Satiety Responsiveness (SR), Emotional under-eating (EUE), Food Fussiness (FF) and Slowness in Eating (SE). Results. Two hundred and fifty-five adults were included in the study; median age was 20 years old. 75% were females. 38% of the subjects were overweight/obese. We found a significant association of rs696217 variant with the apetitive traits: EF, FR and SR; these scores were higher in GG carriers in comparison to GT/TT carriers. For rs7799039 variant, we found an association with EUE and FF traits; the percentage of subjects with high-scores in these traits was higher in GG carriers in comparison to GA/AA carriers. No association was found between the body composition parameters and the studied genetic variants in GHRL and LEP.Conclusion. These results show an association between genetic variants in GHRL and LEP with appetitive traits in young Mexican adults, suggesting an influence in eating behaviors that may indirectly impact on the risk of obesity. [ABSTRACT FROM AUTHOR] |
| Copyright of Archivos Latinoamericanos de Nutrición is the property of Sociedad Latinoamericana de Nutricion and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 173790561 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: GENETIC VARIANTS IN GHRELIN AND LEPTIN ARE ASSOCIATED WITH APPETITIVE TRAITS BUT NOT WITH BODY COMPOSITION PARAMETERS IN YOUNG ADULTS FROM WESTERN MEXICO. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Espinoza+García%2C+Astrid+Selene%22">Espinoza García, Astrid Selene</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Díaz+Chávez%2C+Rosa+Lilian%22">Díaz Chávez, Rosa Lilian</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Parra+Rojas%2C+Isela%22">Parra Rojas, Isela</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Valdés+Miramontes%2C+Elia+Herminia%22">Valdés Miramontes, Elia Herminia</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Reyes-Castillo%2C+Zyanya%22">Reyes-Castillo, Zyanya</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Archivos+Latinoamericanos+de+Nutrición%22">Archivos Latinoamericanos de Nutrición</searchLink>. 2023 Suppl 1, Vol. 73, p175-175. 1/2p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22YOUNG+adults%22">YOUNG adults</searchLink><br /><searchLink fieldCode="DE" term="%22GENETIC+variation%22">GENETIC variation</searchLink><br /><searchLink fieldCode="DE" term="%22GHRELIN%22">GHRELIN</searchLink><br /><searchLink fieldCode="DE" term="%22FOOD+fussiness%22">FOOD fussiness</searchLink><br /><searchLink fieldCode="DE" term="%22GHRELIN+receptors%22">GHRELIN receptors</searchLink><br /><searchLink fieldCode="DE" term="%22POLYACRYLAMIDE+gel+electrophoresis%22">POLYACRYLAMIDE gel electrophoresis</searchLink><br /><searchLink fieldCode="DE" term="%22BODY+composition%22">BODY composition</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22MEXICO%22">MEXICO</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Introduction. Obesity is a complex condition influenced by interactions between environmental, behavioral, and genetic factors. Several genes are involved in appetite regulation, such as ghrelin (GHRL) and leptin (LEP). Variants in these genes have been linked to metabolic effects and appetite through eating behaviors via the Behavioral Susceptibility Theory (BST). Purpose. This study aimed to evaluate the association of genetic variants at GHRL (rs27647 and rs696217) and LEP genes (rs7799039), with body composition parameters and explore possible associations with appetitive traits in young adults from western Mexico. Methods. Blood samples were obtained, and parameters of body composition were measured by bioelectrical impedance. Amplification and genotyping of rs27647, rs696217 and rs7799039 were performed with PCR-RFLP technique (using BsrI, DraI and BhaI enzymes, respectively) and visualized with polyacrylamide gel electrophoresis technique. Appetitive traits were assessed via the Adult Eating Behaviour Questionnaire, which comprises 'food approach' subscales: Food Responsiveness (FR), Enjoyment of Food (EF) and Emotional Over-eating (EOE) and 'food avoidance' subscales: Satiety Responsiveness (SR), Emotional under-eating (EUE), Food Fussiness (FF) and Slowness in Eating (SE). Results. Two hundred and fifty-five adults were included in the study; median age was 20 years old. 75% were females. 38% of the subjects were overweight/obese. We found a significant association of rs696217 variant with the apetitive traits: EF, FR and SR; these scores were higher in GG carriers in comparison to GT/TT carriers. For rs7799039 variant, we found an association with EUE and FF traits; the percentage of subjects with high-scores in these traits was higher in GG carriers in comparison to GA/AA carriers. No association was found between the body composition parameters and the studied genetic variants in GHRL and LEP.Conclusion. These results show an association between genetic variants in GHRL and LEP with appetitive traits in young Mexican adults, suggesting an influence in eating behaviors that may indirectly impact on the risk of obesity. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Archivos Latinoamericanos de Nutrición is the property of Sociedad Latinoamericana de Nutricion and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.37527/2023.73.S1 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 0 StartPage: 175 Subjects: – SubjectFull: YOUNG adults Type: general – SubjectFull: GENETIC variation Type: general – SubjectFull: GHRELIN Type: general – SubjectFull: FOOD fussiness Type: general – SubjectFull: GHRELIN receptors Type: general – SubjectFull: POLYACRYLAMIDE gel electrophoresis Type: general – SubjectFull: BODY composition Type: general – SubjectFull: MEXICO Type: general Titles: – TitleFull: GENETIC VARIANTS IN GHRELIN AND LEPTIN ARE ASSOCIATED WITH APPETITIVE TRAITS BUT NOT WITH BODY COMPOSITION PARAMETERS IN YOUNG ADULTS FROM WESTERN MEXICO. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Espinoza García, Astrid Selene – PersonEntity: Name: NameFull: Díaz Chávez, Rosa Lilian – PersonEntity: Name: NameFull: Parra Rojas, Isela – PersonEntity: Name: NameFull: Valdés Miramontes, Elia Herminia – PersonEntity: Name: NameFull: Reyes-Castillo, Zyanya IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 10 Text: 2023 Suppl 1 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 00040622 Numbering: – Type: volume Value: 73 Titles: – TitleFull: Archivos Latinoamericanos de Nutrición Type: main |
| ResultId | 1 |
