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Circulating sex hormones in women with severe anxiety during pregnancy.

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Title: Circulating sex hormones in women with severe anxiety during pregnancy.
Alternate Title: Hormonas sexuales circulantes en mujeres con ansiedad severa durante el embarazo.
Authors: Leff-Gelman, Philippe1 (AUTHOR) pleff2020@gmail.com, Camacho-Arroyo, Ignacio2 (AUTHOR), Camacho Pacheco, Rodrigo Tonalli3 (AUTHOR), Coronel Cruz, Fausto Moisés4 (AUTHOR), Gaspard Cervantes, Annette Valerie4 (AUTHOR), Jiménez Aquino, Laura Elena1 (AUTHOR), Solares-Bravo, Melissa5 (AUTHOR), Flores-Ramos, Mónica5,6 (AUTHOR)
Source: Salud Mental. Jan/Feb2024, Vol. 47 Issue 1, p3-12. 10p.
Subjects: ANXIETY, STEROIDS, SEX hormones, PREGNANT women, PSYCHOLOGICAL stress, PROGESTERONE, TESTOSTERONE, ESTRADIOL
Abstract (English): Introduction. Anxiety, mood- and stress-related behaviors are regulated by sex hormones in pregnant and non-pregnant women. Very scarce information exists about the role of sex steroids in pregnant women displaying high levels of anxiety. Objective. To determine sex hormones serum levels in pregnant women exhibiting high levels of anxiety symptoms. Method. The Hamilton Anxiety Rating Scale (HARS/ HAM-A) was used to assess the intensity of anxiety symptoms in third-trimester pregnant women. Two groups were included in the study, pregnant women exhibiting severe anxiety (ANX; HARS scores ≥ 25; n = 101) and healthy control subjects (CTRL; n = 40) displaying lower scores for anxiety (HARS scores ≤ 7). Estradiol (E2), progesterone (P4), and testosterone (T) serum levels were measured using a standard chemiluminescent immunoassay. Bivariate and partial correlations were performed to detect significant associations between groups, clinical measures, biochemical data, and HARS scores. Results. The anxiety group (ANX) showed an increase in E2 and T serum levels (p < .001) compared to CTRL. Conversely, significantly lower P4 levels were found in the symptomatic group (p < .001) as compared to the CTRL hormone values. The P4:E2 index was significantly reduced in pregnant women with high levels of anxiety (p < .001). Negative correlations between anxiety (HARS) scores, P4 serum levels (p = .02), and P4:E2 ratio (p = .04) were found in the symptomatic group. Conversely, T serum levels displayed a positive association (p = .001) with high levels of anxiety symptoms in the same group, after adjusting our data by clinical confounders. Discussion and conclusion. Serum levels of sex-steroid hormones are altered in pregnant women exhibiting severe anxiety. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción. La ansiedad, el estado de ánimo y el estrés están regulados por diversos esteroides sexuales. Existe poca información sobre el papel que juegan estos esteroides en mujeres embarazadas con niveles elevados de ansiedad. Objetivo. Determinar los niveles séricos de hormonas sexuales en mujeres embarazadas con altos índices de síntomas de ansiedad con respecto a mujeres gestantes sanas. Método. Determinación de la intensidad de síntomas ansiosos empleando la escala de Hamilton de Ansiedad (HAM-A) en 141 mujeres embarazadas en el tercer trimestre de gestación. Cuantificación de los niveles séricos de estradiol (E2), progesterona (P4) y testosterona (T) por inmunoensayo estándar. Aplicación de las correlaciones de Pearson para detectar asociaciones entre parámetros clínicos y valores hormonales entre los grupos de estudio. Resultados. Las mujeres con ansiedad severa (ANX; n = 101; HAM-A ≥ 25) mostraron niveles séricos más altos de E2 y T (p < .001), así como niveles más bajos de P4 (p < .001) en relación con el grupo control (CTRL, n = 40, HAM-A < 7). Se detectó una disminución significativa en el índice P4:E2 en el grupo de ANX (p < .001) y se observaron correlaciones negativas y positivas entre los puntajes elevados de ansiedad con los niveles circulantes de P4 (p = .02), en la taza P4:E2 (p = .04) y en los niveles séricos de T (p = .001) respectivamente, al ajustar nuestros datos con variables confusoras. Discusión y conclusión. Los niveles circulantes de los esteroides sexuales se encontraron alterados en mujeres con ansiedad severa. [ABSTRACT FROM AUTHOR]
Copyright of Salud Mental is the property of Instituto Nacional de Psiquiatria Ramon de la Fuente and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Circulating sex hormones in women with severe anxiety during pregnancy.
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  Data: Hormonas sexuales circulantes en mujeres con ansiedad severa durante el embarazo.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Leff-Gelman%2C+Philippe%22&quot;&gt;Leff-Gelman, Philippe&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; pleff2020@gmail.com&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Camacho-Arroyo%2C+Ignacio%22&quot;&gt;Camacho-Arroyo, Ignacio&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Camacho+Pacheco%2C+Rodrigo+Tonalli%22&quot;&gt;Camacho Pacheco, Rodrigo Tonalli&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Coronel+Cruz%2C+Fausto+Mois&#233;s%22&quot;&gt;Coronel Cruz, Fausto Mois&#233;s&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gaspard+Cervantes%2C+Annette+Valerie%22&quot;&gt;Gaspard Cervantes, Annette Valerie&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jim&#233;nez+Aquino%2C+Laura+Elena%22&quot;&gt;Jim&#233;nez Aquino, Laura Elena&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Solares-Bravo%2C+Melissa%22&quot;&gt;Solares-Bravo, Melissa&lt;/searchLink&gt;&lt;relatesTo&gt;5&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Flores-Ramos%2C+M&#243;nica%22&quot;&gt;Flores-Ramos, M&#243;nica&lt;/searchLink&gt;&lt;relatesTo&gt;5,6&lt;/relatesTo&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Salud+Mental%22&quot;&gt;Salud Mental&lt;/searchLink&gt;. Jan/Feb2024, Vol. 47 Issue 1, p3-12. 10p.
– Name: Subject
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22ANXIETY%22&quot;&gt;ANXIETY&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22STEROIDS%22&quot;&gt;STEROIDS&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22SEX+hormones%22&quot;&gt;SEX hormones&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22PREGNANT+women%22&quot;&gt;PREGNANT women&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22PSYCHOLOGICAL+stress%22&quot;&gt;PSYCHOLOGICAL stress&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22PROGESTERONE%22&quot;&gt;PROGESTERONE&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22TESTOSTERONE%22&quot;&gt;TESTOSTERONE&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22ESTRADIOL%22&quot;&gt;ESTRADIOL&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Introduction. Anxiety, mood- and stress-related behaviors are regulated by sex hormones in pregnant and non-pregnant women. Very scarce information exists about the role of sex steroids in pregnant women displaying high levels of anxiety. Objective. To determine sex hormones serum levels in pregnant women exhibiting high levels of anxiety symptoms. Method. The Hamilton Anxiety Rating Scale (HARS/ HAM-A) was used to assess the intensity of anxiety symptoms in third-trimester pregnant women. Two groups were included in the study, pregnant women exhibiting severe anxiety (ANX; HARS scores ≥ 25; n = 101) and healthy control subjects (CTRL; n = 40) displaying lower scores for anxiety (HARS scores ≤ 7). Estradiol (E2), progesterone (P4), and testosterone (T) serum levels were measured using a standard chemiluminescent immunoassay. Bivariate and partial correlations were performed to detect significant associations between groups, clinical measures, biochemical data, and HARS scores. Results. The anxiety group (ANX) showed an increase in E2 and T serum levels (p &lt; .001) compared to CTRL. Conversely, significantly lower P4 levels were found in the symptomatic group (p &lt; .001) as compared to the CTRL hormone values. The P4:E2 index was significantly reduced in pregnant women with high levels of anxiety (p &lt; .001). Negative correlations between anxiety (HARS) scores, P4 serum levels (p = .02), and P4:E2 ratio (p = .04) were found in the symptomatic group. Conversely, T serum levels displayed a positive association (p = .001) with high levels of anxiety symptoms in the same group, after adjusting our data by clinical confounders. Discussion and conclusion. Serum levels of sex-steroid hormones are altered in pregnant women exhibiting severe anxiety. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Introducci&#243;n. La ansiedad, el estado de &#225;nimo y el estr&#233;s est&#225;n regulados por diversos esteroides sexuales. Existe poca informaci&#243;n sobre el papel que juegan estos esteroides en mujeres embarazadas con niveles elevados de ansiedad. Objetivo. Determinar los niveles s&#233;ricos de hormonas sexuales en mujeres embarazadas con altos &#237;ndices de s&#237;ntomas de ansiedad con respecto a mujeres gestantes sanas. M&#233;todo. Determinaci&#243;n de la intensidad de s&#237;ntomas ansiosos empleando la escala de Hamilton de Ansiedad (HAM-A) en 141 mujeres embarazadas en el tercer trimestre de gestaci&#243;n. Cuantificaci&#243;n de los niveles s&#233;ricos de estradiol (E2), progesterona (P4) y testosterona (T) por inmunoensayo est&#225;ndar. Aplicaci&#243;n de las correlaciones de Pearson para detectar asociaciones entre par&#225;metros cl&#237;nicos y valores hormonales entre los grupos de estudio. Resultados. Las mujeres con ansiedad severa (ANX; n = 101; HAM-A ≥ 25) mostraron niveles s&#233;ricos m&#225;s altos de E2 y T (p &lt; .001), as&#237; como niveles m&#225;s bajos de P4 (p &lt; .001) en relaci&#243;n con el grupo control (CTRL, n = 40, HAM-A &lt; 7). Se detect&#243; una disminuci&#243;n significativa en el &#237;ndice P4:E2 en el grupo de ANX (p &lt; .001) y se observaron correlaciones negativas y positivas entre los puntajes elevados de ansiedad con los niveles circulantes de P4 (p = .02), en la taza P4:E2 (p = .04) y en los niveles s&#233;ricos de T (p = .001) respectivamente, al ajustar nuestros datos con variables confusoras. Discusi&#243;n y conclusi&#243;n. Los niveles circulantes de los esteroides sexuales se encontraron alterados en mujeres con ansiedad severa. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Salud Mental is the property of Instituto Nacional de Psiquiatria Ramon de la Fuente and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
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      – Type: doi
        Value: 10.17711/SM.0185-3325.2024.002
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 3
    Subjects:
      – SubjectFull: ANXIETY
        Type: general
      – SubjectFull: STEROIDS
        Type: general
      – SubjectFull: SEX hormones
        Type: general
      – SubjectFull: PREGNANT women
        Type: general
      – SubjectFull: PSYCHOLOGICAL stress
        Type: general
      – SubjectFull: PROGESTERONE
        Type: general
      – SubjectFull: TESTOSTERONE
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      – SubjectFull: ESTRADIOL
        Type: general
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      – TitleFull: Circulating sex hormones in women with severe anxiety during pregnancy.
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            NameFull: Coronel Cruz, Fausto Moisés
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              M: 01
              Text: Jan/Feb2024
              Type: published
              Y: 2024
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