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Location and morphology of cortical lesions in multiple sclerosis.

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Title: Location and morphology of cortical lesions in multiple sclerosis.
Alternate Title: Localización y morfología de las lesiones corticales en la esclerosis multiple.
Authors: Bertado-Ramírez, Nancy R.1, García-Santiago, José A.1, Calderón-Cánovas, José P.2, Juárez-Mora, Yasmín2, García-Galicia, Arturo3 neurogarciagalicia@yahoo.com.mx, Montiel-Jarquín, Álvaro J.4, Loría-Castellanos, Jorge5
Source: Revista Mexicana de Neurociencia. Jan/Feb2024, Vol. 25 Issue 1, p10-14. 5p.
Subjects: MULTIPLE sclerosis, CENTRAL nervous system diseases, MAGNETIC resonance imaging, DISEASE progression, DESCRIPTIVE statistics, DISEASE relapse
Abstract (English): Objective: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Diagnosis is based on the Mc-Donalds criteria, magnetic resonance imaging (MRI) studies, and the expanded disability status scale (EDSS) which assesses disease progression. These criteria do not include the recently described cortical lesions. The aim of the study was to describe the most frequent location and morphology of cortical lesions in patients with MS in Puebla, Mexico. Methods: A descriptive, retrospective, cross-sectional, and analytical study was conducted on patients with MS at a tertiary care hospital. Patients diagnosed with relapsing-remitting, secondary-progressive, and progressive-relapsing MS variants with cranial magnetic resonance imaging were included in the study. Age, sex, MS variant, EDSS score, cognitive impairment, annual relapse rate, morphology, location, and number of cortical lesions were evaluated. Descriptive statistics were used. To compare features between groups, the χ2 test was used, and for correlations, the Spearman's Correlation Coefficient was used. A p = 0.05 was considered significant. Results: Twenty-five patients met the selection criteria. The most frequent location of cortical lesions was the parietal region 84%, and the second was the temporal region 16%. The most common morphology was juxtacortical at 64% and mixed at 36%. The most frequent variant of MS was relapsing-remitting, present in 92%, and 8% had the secondary progressive variant. In the EDSS scale, the scores most frequently observed were 0.0 and 3.5. Conclusions: The most frequent location of cortical lesions was in the parietal region, and the most common morphology was juxtacortical. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Objetivo: La esclerosis múltiple es una enfermedad desmielinizante inflamatoria crónica del sistema nervioso central. El diagnóstico se basa en los criterios de Mc-Donalds, los estudios de Resonancia Magnética y la Escala Expandida del Estado de Discapacidad (EDSS) que evalúa la progresión de la enfermedad. Estos criterios no incluyen las lesiones corticales descritas recientemente. Describir la localización y morfología más frecuente de lesiones corticales en pacientes con esclerosis múltiple en Puebla, México. Métodos: Se realizó un estudio descriptivo, retrospectivo, transversal y analítico en pacientes con esclerosis múltiple en un hospital de tercer nivel de atención. Se incluyeron pacientes con diagnóstico de Esclerosis Múltiple con variantes Remitente-Recurrente, Secundaria-Progresiva y Progresiva-Recurrente con resonancia magnética de cráneo. Se evaluó edad, sexo, variante de esclerosis múltiple, puntaje de EDSS, deterioro cognitivo, tasa de recaída anual, morfología, ubicación y numero de lesiones corticales. Se utilizó estadística descriptiva. Para comparar características entre grupos se utilizó χ2, para correlaciones se utilizó Coeficiente de Correlación de Spearman. Una p = 0.05 se consideró significativa. Resultados: 25 pacientes cumplieron con criterios de selección. La localización más frecuente de lesiones corticales fue la región parietal 84% y la segunda temporal 16%. La morfología más frecuente fue la yuxtacortical en un 64%, y la mixta en 36%. La variante más frecuente de esclerosis múltiple fue Remitente-Recurrente presente en 92%, y 8% la variante Secundaria Progresiva. En la escala de EDDS la puntuación con mayor frecuencia fue 0.0 y 3.5. Conclusiones: La localización más frecuente de las lesiones corticales fue en región parietal y la morfología más frecuente la yuxtacortical. [ABSTRACT FROM AUTHOR]
Copyright of Revista Mexicana de Neurociencia is the property of Academia Mexicana de Neurologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Location and morphology of cortical lesions in multiple sclerosis.
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  Data: Localización y morfología de las lesiones corticales en la esclerosis multiple.
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  Data: <searchLink fieldCode="AR" term="%22Bertado-Ramírez%2C+Nancy+R%2E%22">Bertado-Ramírez, Nancy R.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22García-Santiago%2C+José+A%2E%22">García-Santiago, José A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Calderón-Cánovas%2C+José+P%2E%22">Calderón-Cánovas, José P.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Juárez-Mora%2C+Yasmín%22">Juárez-Mora, Yasmín</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22García-Galicia%2C+Arturo%22">García-Galicia, Arturo</searchLink><relatesTo>3</relatesTo><i> neurogarciagalicia@yahoo.com.mx</i><br /><searchLink fieldCode="AR" term="%22Montiel-Jarquín%2C+Álvaro+J%2E%22">Montiel-Jarquín, Álvaro J.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Loría-Castellanos%2C+Jorge%22">Loría-Castellanos, Jorge</searchLink><relatesTo>5</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Revista+Mexicana+de+Neurociencia%22">Revista Mexicana de Neurociencia</searchLink>. Jan/Feb2024, Vol. 25 Issue 1, p10-14. 5p.
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  Data: <searchLink fieldCode="DE" term="%22MULTIPLE+sclerosis%22">MULTIPLE sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22CENTRAL+nervous+system+diseases%22">CENTRAL nervous system diseases</searchLink><br /><searchLink fieldCode="DE" term="%22MAGNETIC+resonance+imaging%22">MAGNETIC resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22DISEASE+progression%22">DISEASE progression</searchLink><br /><searchLink fieldCode="DE" term="%22DESCRIPTIVE+statistics%22">DESCRIPTIVE statistics</searchLink><br /><searchLink fieldCode="DE" term="%22DISEASE+relapse%22">DISEASE relapse</searchLink>
– Name: Abstract
  Label: Abstract (English)
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  Data: Objective: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Diagnosis is based on the Mc-Donalds criteria, magnetic resonance imaging (MRI) studies, and the expanded disability status scale (EDSS) which assesses disease progression. These criteria do not include the recently described cortical lesions. The aim of the study was to describe the most frequent location and morphology of cortical lesions in patients with MS in Puebla, Mexico. Methods: A descriptive, retrospective, cross-sectional, and analytical study was conducted on patients with MS at a tertiary care hospital. Patients diagnosed with relapsing-remitting, secondary-progressive, and progressive-relapsing MS variants with cranial magnetic resonance imaging were included in the study. Age, sex, MS variant, EDSS score, cognitive impairment, annual relapse rate, morphology, location, and number of cortical lesions were evaluated. Descriptive statistics were used. To compare features between groups, the χ2 test was used, and for correlations, the Spearman's Correlation Coefficient was used. A p = 0.05 was considered significant. Results: Twenty-five patients met the selection criteria. The most frequent location of cortical lesions was the parietal region 84%, and the second was the temporal region 16%. The most common morphology was juxtacortical at 64% and mixed at 36%. The most frequent variant of MS was relapsing-remitting, present in 92%, and 8% had the secondary progressive variant. In the EDSS scale, the scores most frequently observed were 0.0 and 3.5. Conclusions: The most frequent location of cortical lesions was in the parietal region, and the most common morphology was juxtacortical. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Objetivo: La esclerosis múltiple es una enfermedad desmielinizante inflamatoria crónica del sistema nervioso central. El diagnóstico se basa en los criterios de Mc-Donalds, los estudios de Resonancia Magnética y la Escala Expandida del Estado de Discapacidad (EDSS) que evalúa la progresión de la enfermedad. Estos criterios no incluyen las lesiones corticales descritas recientemente. Describir la localización y morfología más frecuente de lesiones corticales en pacientes con esclerosis múltiple en Puebla, México. Métodos: Se realizó un estudio descriptivo, retrospectivo, transversal y analítico en pacientes con esclerosis múltiple en un hospital de tercer nivel de atención. Se incluyeron pacientes con diagnóstico de Esclerosis Múltiple con variantes Remitente-Recurrente, Secundaria-Progresiva y Progresiva-Recurrente con resonancia magnética de cráneo. Se evaluó edad, sexo, variante de esclerosis múltiple, puntaje de EDSS, deterioro cognitivo, tasa de recaída anual, morfología, ubicación y numero de lesiones corticales. Se utilizó estadística descriptiva. Para comparar características entre grupos se utilizó χ2, para correlaciones se utilizó Coeficiente de Correlación de Spearman. Una p = 0.05 se consideró significativa. Resultados: 25 pacientes cumplieron con criterios de selección. La localización más frecuente de lesiones corticales fue la región parietal 84% y la segunda temporal 16%. La morfología más frecuente fue la yuxtacortical en un 64%, y la mixta en 36%. La variante más frecuente de esclerosis múltiple fue Remitente-Recurrente presente en 92%, y 8% la variante Secundaria Progresiva. En la escala de EDDS la puntuación con mayor frecuencia fue 0.0 y 3.5. Conclusiones: La localización más frecuente de las lesiones corticales fue en región parietal y la morfología más frecuente la yuxtacortical. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Revista Mexicana de Neurociencia is the property of Academia Mexicana de Neurologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.24875/RMN.23000062
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        Text: English
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      – SubjectFull: MULTIPLE sclerosis
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      – SubjectFull: MAGNETIC resonance imaging
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              Text: Jan/Feb2024
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