Bibliographic Details
| Title: |
Guía de práctica clínica para el tratamiento del cáncer de próstata metastásico hormonosensible en el Seguro Social del Perú (EsSalud). |
| Alternate Title: |
Clinical practice guideline for the treatment of hormone-sensitive metastatic prostate cancer in the Peruvian Social Security (EsSalud). |
| Authors: |
Cuevas-Muñoz, Nelson1,2, Broncano-Huasasquiche, Oswaldo1,3, Goicochea-Lugo, Sergio1,4, Delgado-Flores, Carolina J.1, Taype-Rondan, Alvaro1, Fernandez-Quiroz, Eliana L.5,6, Livano Yberico, Teofilo3, Cuentas-Jara, Mariano2, Cordier-Mariaca, Abel3, Alberto Velarde-Ponce, Luís2, Delgado-Iriarte, Jesús7, Salvador-Salvador, Stefany1, Santos-Sánchez, Vladimir1 ietsi.gpc@gmail.com |
| Source: |
Revista del Cuerpo Médico del Hospital Nacional Almanzor Aguinaga Asenjo. 2023, Vol. 16 Issue 4, p1-22. 22p. |
| Abstract (English): |
Introduction: This article summarizes the clinical practice guideline (CPG) for the treatment of metastatic hormone-sensitive prostate cancer in the Social Security of Peru (EsSalud). Objective: To provide evidence-based clinical recommendations for the treatment of adults with hormone-sensitive metastatic adenocarcinoma of the prostate with de novo or recurrent presentation and high or low metastatic volume in EsSalud. Methods: A guideline development group (GDG) was formed, which included specialist physicians and methodologists, who formulated clinical questions. Systematic searches were conducted for systematic reviews and - when deemed relevant - primary studies in PubMed during 2022. Evidence was selected to answer each of the clinical questions posed. The certainty of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. In periodic working meetings, the GEG used the GRADE methodology to review the evidence and formulate recommendations. The CPG was reviewed by external experts before its approval. Results: The CPG addressed 6 clinical questions, divided into 2 main topics: considerations on androgen deprivation therapy (ADT) and ADT combined with other therapies. Based on these questions, 10 recommendations were formulated (4 strong and 6 conditional), and 6 points of good clinical practice. Conclusion: Evidence-based recommendations were issued for the management of patients with this pathology. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
Introducción: Este artículo resume la guía de práctica clínica (GPC) para el tratamiento del cáncer de próstata metastásico hormonosensible en el Seguro Social del Perú (EsSalud). Objetivo: Proveer recomendaciones clínicas basadas en evidencia para el tratamiento de adultos con adenocarcinoma de próstata metastásico hormonosensible con presentación de novo o recurrente y de alto o bajo volumen metastásico en EsSalud. Métodos: Se conformó un grupo elaborador de la guía (GEG) que incluyó médicos especialistas y metodólogos, el cual formuló preguntas clínicas. Se realizaron búsquedas sistemáticas de revisiones sistemáticas y -cuando fue considerado pertinente-estudios primarios en PubMed durante el 2022. Se seleccionó la evidencia para responder cada una de las preguntas clínicas planteadas. Se evaluó la certeza de evidencia usando la metodología Grading of Recommendations Assessment, Development, and Evaluation (GRADE). En reuniones de trabajo periódicas, el GEG usó la metodología GRADE para revisar la evidencia y formular las recomendaciones. La GPC fue revisada por expertos externos antes de su aprobación. Resultados: La GPC abordó 6 preguntas clínicas, divididas en 2 temas principales: consideraciones sobre la terapia de deprivación androgénica (TDA) y TDA combinada con otras terapias. En base a dichas preguntas se formularon 10 recomendaciones (4 fuertes y 6 condicionales) y 6 puntos de buena práctica clínica. Conclusión: Se emitieron recomendaciones basadas en evidencia para el manejo de pacientes con esta patología. [ABSTRACT FROM AUTHOR] |
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| Database: |
MedicLatina |
