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Influence of sexual hormones on Chagas disease.

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Title: Influence of sexual hormones on Chagas disease.
Alternate Title: Influencia de las hormonas sexuales en la enfermedad de Chagas.
Authors: Reboreda-Hernández, Óscar A.1, Ortiz-Butron, Rocío2, Nogueda-Torres, Benjamin3, González-Rodríguez, Nayeli1 bassolsae@gmail.com
Source: Archivos de Cardiología de México. abr-jun2024, Vol. 94 Issue 2, p127-132. 6p.
Subjects: CHAGAS' disease, SEX hormones, PARAMETRIC equations, PARASITEMIA, HISTOPATHOLOGY, TWO-way analysis of variance, ESTRADIOL
Abstract (English): Objective: Analyze sex hormone's influence during Chagas disease. Methods: Male and female BALB/c mice were divided into six groups, four experimental (sham, orchiectomized, orchiectomized and supplemented with estradiol, orchiectomized supplemented with testosterone, oophorectomized, oophorectomized and supplemented with estradiol, and oophorectomized and supplemented with testosterone), and two control (healthy and intraperitoneally with T. cruzi strain NINOA infected). Clinical data were recorded daily, parasitemia was evaluated using a Neubauer chamber during the infection, and heart histopathological analysis was performed using the paraffin embedding technique. To analyze parasitemia curves and the area under the parametric curves, two-way ANOVA test was performed to correlate groups' data. P-values < 0.05 were considered statistically significant. Results: Higher mortality rates, cardiomegaly, hepatomegaly, ascites, edema, higher parasitemia levels, more amastigote nests, and more severe inflammatory infiltrate were found in higher testosterone concentration mice, whereas in higher estradiol concentration groups, paresia, prostration, edema, and necrosis were found. Conclusions: Our results showed that testosterone increased infection severity, whereas estradiol had the opposite effect. This research improves the understanding of sex hormones' infuence upon this infection to contribute with the handling of Chagas' disease. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Objetivo: Analizar la influencia de las hormonas durante la enfermedad de Chagas. Métodos: Se separaron grupos de ratones macho y hembras BALB/c, todos infectados con T. cruzi (cepa NINOA), 4 grupos experimentales de machos (Sham, orquidectamizados, orquidectimezados y suplementados con estradiol, orquidectamizaos y suplementados con testosterona). 4 grupos experimentales de hembras (oforectomizadas, oforectomizadas y suplementadas con estradiol, oforectomizadas y suplementadas con testosterona y sham), and y dos grupos control para cada sexo (sin infección e infectados intraperitonealmente con T. cruzi (cepa NINOA). Los datos clínicos fueron registrados diariamente, la parasitemia fue evaluada durante toda la infección utilizando una cámara de Neubauer y el análisis histopatológico del corazón fue realizada con la técnica de inclusión en parafina. Para el análisis de las curvas de parasitemia y el área bajo la curva, se realizó una prueba de ANOVA de dos vías, p < 0.05 fueron considerados estadísticamente diferentes. Resultados: Las mayores tasas de mortalidad, cardiomegalia, hepatomegalia y mayor infiltrado inflamatorio, se encontró en los ratones con una mayor concentración de testosterona. En contraste los ratones con mayor concentración de estradiol presentaron paresia, postración edema y necrosis. Conclusiones: Nuestros resultados ponen en manifiesto que la testosterona incrementa la severidad del curso de la enfermedad de Chagas, mientras que el estradiol tuvo el efecto opuesto. Este trabajo mejora el entendimiento del rol que juegan las hormonas sexuales en esta infección para contribuir en un mejor manejo de la enfermedad de Chagas. [ABSTRACT FROM AUTHOR]
Copyright of Archivos de Cardiología de México is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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DbLabel: MedicLatina
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AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Influence of sexual hormones on Chagas disease.
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  Data: Influencia de las hormonas sexuales en la enfermedad de Chagas.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Reboreda-Hern&#225;ndez%2C+&#211;scar+A%2E%22&quot;&gt;Reboreda-Hern&#225;ndez, &#211;scar A.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ortiz-Butron%2C+Roc&#237;o%22&quot;&gt;Ortiz-Butron, Roc&#237;o&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nogueda-Torres%2C+Benjamin%22&quot;&gt;Nogueda-Torres, Benjamin&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gonz&#225;lez-Rodr&#237;guez%2C+Nayeli%22&quot;&gt;Gonz&#225;lez-Rodr&#237;guez, Nayeli&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; bassolsae@gmail.com&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Archivos+de+Cardiolog&#237;a+de+M&#233;xico%22&quot;&gt;Archivos de Cardiolog&#237;a de M&#233;xico&lt;/searchLink&gt;. abr-jun2024, Vol. 94 Issue 2, p127-132. 6p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22CHAGAS&#39;+disease%22&quot;&gt;CHAGAS&#39; disease&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22SEX+hormones%22&quot;&gt;SEX hormones&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22PARAMETRIC+equations%22&quot;&gt;PARAMETRIC equations&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22PARASITEMIA%22&quot;&gt;PARASITEMIA&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22HISTOPATHOLOGY%22&quot;&gt;HISTOPATHOLOGY&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22TWO-way+analysis+of+variance%22&quot;&gt;TWO-way analysis of variance&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22ESTRADIOL%22&quot;&gt;ESTRADIOL&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Objective: Analyze sex hormone&#39;s influence during Chagas disease. Methods: Male and female BALB/c mice were divided into six groups, four experimental (sham, orchiectomized, orchiectomized and supplemented with estradiol, orchiectomized supplemented with testosterone, oophorectomized, oophorectomized and supplemented with estradiol, and oophorectomized and supplemented with testosterone), and two control (healthy and intraperitoneally with T. cruzi strain NINOA infected). Clinical data were recorded daily, parasitemia was evaluated using a Neubauer chamber during the infection, and heart histopathological analysis was performed using the paraffin embedding technique. To analyze parasitemia curves and the area under the parametric curves, two-way ANOVA test was performed to correlate groups&#39; data. P-values &lt; 0.05 were considered statistically significant. Results: Higher mortality rates, cardiomegaly, hepatomegaly, ascites, edema, higher parasitemia levels, more amastigote nests, and more severe inflammatory infiltrate were found in higher testosterone concentration mice, whereas in higher estradiol concentration groups, paresia, prostration, edema, and necrosis were found. Conclusions: Our results showed that testosterone increased infection severity, whereas estradiol had the opposite effect. This research improves the understanding of sex hormones&#39; infuence upon this infection to contribute with the handling of Chagas&#39; disease. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Objetivo: Analizar la influencia de las hormonas durante la enfermedad de Chagas. M&#233;todos: Se separaron grupos de ratones macho y hembras BALB/c, todos infectados con T. cruzi (cepa NINOA), 4 grupos experimentales de machos (Sham, orquidectamizados, orquidectimezados y suplementados con estradiol, orquidectamizaos y suplementados con testosterona). 4 grupos experimentales de hembras (oforectomizadas, oforectomizadas y suplementadas con estradiol, oforectomizadas y suplementadas con testosterona y sham), and y dos grupos control para cada sexo (sin infecci&#243;n e infectados intraperitonealmente con T. cruzi (cepa NINOA). Los datos cl&#237;nicos fueron registrados diariamente, la parasitemia fue evaluada durante toda la infecci&#243;n utilizando una c&#225;mara de Neubauer y el an&#225;lisis histopatol&#243;gico del coraz&#243;n fue realizada con la t&#233;cnica de inclusi&#243;n en parafina. Para el an&#225;lisis de las curvas de parasitemia y el &#225;rea bajo la curva, se realiz&#243; una prueba de ANOVA de dos v&#237;as, p &lt; 0.05 fueron considerados estad&#237;sticamente diferentes. Resultados: Las mayores tasas de mortalidad, cardiomegalia, hepatomegalia y mayor infiltrado inflamatorio, se encontr&#243; en los ratones con una mayor concentraci&#243;n de testosterona. En contraste los ratones con mayor concentraci&#243;n de estradiol presentaron paresia, postraci&#243;n edema y necrosis. Conclusiones: Nuestros resultados ponen en manifiesto que la testosterona incrementa la severidad del curso de la enfermedad de Chagas, mientras que el estradiol tuvo el efecto opuesto. Este trabajo mejora el entendimiento del rol que juegan las hormonas sexuales en esta infecci&#243;n para contribuir en un mejor manejo de la enfermedad de Chagas. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: &lt;i&gt;Copyright of Archivos de Cardiolog&#237;a de M&#233;xico is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.24875/ACM.23000018
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 127
    Subjects:
      – SubjectFull: CHAGAS' disease
        Type: general
      – SubjectFull: SEX hormones
        Type: general
      – SubjectFull: PARAMETRIC equations
        Type: general
      – SubjectFull: PARASITEMIA
        Type: general
      – SubjectFull: HISTOPATHOLOGY
        Type: general
      – SubjectFull: TWO-way analysis of variance
        Type: general
      – SubjectFull: ESTRADIOL
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      – TitleFull: Influence of sexual hormones on Chagas disease.
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            NameFull: Reboreda-Hernández, Óscar A.
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            NameFull: Ortiz-Butron, Rocío
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            NameFull: Nogueda-Torres, Benjamin
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            NameFull: González-Rodríguez, Nayeli
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              M: 04
              Text: abr-jun2024
              Type: published
              Y: 2024
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