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Systematic Review on the Relationship between Toxoplasmosis and Mental Disorders.

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Title: Systematic Review on the Relationship between Toxoplasmosis and Mental Disorders.
Authors: Bartolomé del Pino, Leticia E.1 lebartolome@universidadviu.com, Zanón-Moreno, Vicente2
Source: Actas Espanolas de Psiquiatria. 2024, Vol. 52 Issue 2, p149-160. 12p.
Subjects: TOXOPLASMOSIS, MENTAL illness, Q fever, META-analysis, HIV, NEUROLOGICAL disorders, BIPOLAR disorder, PUBLIC health surveillance, TOXOPLASMA gondii
Abstract: Background: Toxoplasmosis is a worldwide parasitic zoonosis caused by the protozoan Toxoplasma gondii. In cases of vertical infection, and in immunosuppressed people by the human immunodeficiency virus (HIV) serious clinical conditions may appear, while immunocompetent people do not present symptoms. However, T. gondii infection has been linked to several mental disorders for decades. Objective: To substantiate the possible relationship between T. gondii and mental disorders and suggest control and prevention strategies. Material and Methods: A systematic review has been carried out to analyze the relationship between T. gondii exposure (presence of IgG) and the onset of mental disorders in minors and adults. The etiopathogenic mechanisms described by the authors have also been included and the systems of surveillance, prevention and control of infection have been evaluated. Results: Several processes linked to the presence of cysts and the reactivation of the parasite in certain situations produce an immune and inflammatory response. Also, direct and indirect actions on different neurotransmitters. These mechanisms, together with other environmental and genetic factors, would predispose to different psychiatric pathologies. Conclusions: Due to the limits of the study, no conclusions can be drawn in childhood and adolescence. However, the results of this systematic review show a possible association of schizophrenia, bipolar disorder and compul-sive disorder with T. gondii infection in adults. There is a need to improve control, integrated surveillance and extend prevention measures to the entire population. [ABSTRACT FROM AUTHOR]
Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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  Data: Systematic Review on the Relationship between Toxoplasmosis and Mental Disorders.
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  Data: <searchLink fieldCode="AR" term="%22Bartolomé+del+Pino%2C+Leticia+E%2E%22">Bartolomé del Pino, Leticia E.</searchLink><relatesTo>1</relatesTo><i> lebartolome@universidadviu.com</i><br /><searchLink fieldCode="AR" term="%22Zanón-Moreno%2C+Vicente%22">Zanón-Moreno, Vicente</searchLink><relatesTo>2</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Actas+Espanolas+de+Psiquiatria%22">Actas Espanolas de Psiquiatria</searchLink>. 2024, Vol. 52 Issue 2, p149-160. 12p.
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  Data: <searchLink fieldCode="DE" term="%22TOXOPLASMOSIS%22">TOXOPLASMOSIS</searchLink><br /><searchLink fieldCode="DE" term="%22MENTAL+illness%22">MENTAL illness</searchLink><br /><searchLink fieldCode="DE" term="%22Q+fever%22">Q fever</searchLink><br /><searchLink fieldCode="DE" term="%22META-analysis%22">META-analysis</searchLink><br /><searchLink fieldCode="DE" term="%22HIV%22">HIV</searchLink><br /><searchLink fieldCode="DE" term="%22NEUROLOGICAL+disorders%22">NEUROLOGICAL disorders</searchLink><br /><searchLink fieldCode="DE" term="%22BIPOLAR+disorder%22">BIPOLAR disorder</searchLink><br /><searchLink fieldCode="DE" term="%22PUBLIC+health+surveillance%22">PUBLIC health surveillance</searchLink><br /><searchLink fieldCode="DE" term="%22TOXOPLASMA+gondii%22">TOXOPLASMA gondii</searchLink>
– Name: Abstract
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  Data: Background: Toxoplasmosis is a worldwide parasitic zoonosis caused by the protozoan Toxoplasma gondii. In cases of vertical infection, and in immunosuppressed people by the human immunodeficiency virus (HIV) serious clinical conditions may appear, while immunocompetent people do not present symptoms. However, T. gondii infection has been linked to several mental disorders for decades. Objective: To substantiate the possible relationship between T. gondii and mental disorders and suggest control and prevention strategies. Material and Methods: A systematic review has been carried out to analyze the relationship between T. gondii exposure (presence of IgG) and the onset of mental disorders in minors and adults. The etiopathogenic mechanisms described by the authors have also been included and the systems of surveillance, prevention and control of infection have been evaluated. Results: Several processes linked to the presence of cysts and the reactivation of the parasite in certain situations produce an immune and inflammatory response. Also, direct and indirect actions on different neurotransmitters. These mechanisms, together with other environmental and genetic factors, would predispose to different psychiatric pathologies. Conclusions: Due to the limits of the study, no conclusions can be drawn in childhood and adolescence. However, the results of this systematic review show a possible association of schizophrenia, bipolar disorder and compul-sive disorder with T. gondii infection in adults. There is a need to improve control, integrated surveillance and extend prevention measures to the entire population. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=177101819
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        Value: 10.62641/aep.v52i2.1658
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        Text: English
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      – SubjectFull: TOXOPLASMOSIS
        Type: general
      – SubjectFull: MENTAL illness
        Type: general
      – SubjectFull: Q fever
        Type: general
      – SubjectFull: META-analysis
        Type: general
      – SubjectFull: HIV
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      – SubjectFull: NEUROLOGICAL disorders
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      – SubjectFull: BIPOLAR disorder
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      – SubjectFull: PUBLIC health surveillance
        Type: general
      – SubjectFull: TOXOPLASMA gondii
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      – TitleFull: Systematic Review on the Relationship between Toxoplasmosis and Mental Disorders.
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              Text: 2024
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