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Can direct bilirubin-to-lymphocyte ratio predict surgery for pediatric adhesive small bowel obstruction?

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Title: Can direct bilirubin-to-lymphocyte ratio predict surgery for pediatric adhesive small bowel obstruction?
Alternate Title: ¿La relación bilirrubina directa-linfocitos puede predecir la cirugía para la obstrucción adhesiva del intestino delgado en niños?
Authors: Azizoglu, Mustafa1 mdmazizoglu@gmail.com, Arslan, Serkan2, Kamci, Tahsin O.2, Basuguy, Erol2, Aydogdu, Bahattin3, Karabel, Müsemma A.4, Okur, Mehmet H.2
Source: Cirugía y Cirujanos. may/jun2024, Vol. 92 Issue 3, p307-313. 7p.
Subjects: BOWEL obstructions, BILIRUBIN, LYMPHOCYTES, ENTEROHEPATIC circulation, BACTEREMIA
Abstract (English): Objective: Estimating which patients might require surgical intervention is crucial. Patients with complete bowel obstructions exhibit disrupted enterohepatic cycles of bile and bacteremia due to bacterial translocation. The goal of this study was to develop a prediction index using laboratory inflammatory data to identify patients who may need surgery. Materials and methods: The patients were divided into two groups based on their management strategy: Non-operative management (Group 1) and surgical management (Group 2). Results: The indirect bilirubin, direct bilirubin, and total bilirubin were significantly higher in Group 2 than in Group 1 (p = 0.001, p < 0.001, and p < 0.001, respectively). The neutrophil-to-lymphocyte ratio (NLR), platelet-to-NLR (PNLR), and direct bilirubin-to-lymphocyte ratio (DBR) were significantly higher in Group 2 compared to Group 1 (p = 0.041, p = 0.020, and p < 0.001, respectively). In group 2, 78% have viable bowels. Resection was performed in 40% of cases, with 12% mortality and a 10-day average hospital stay. DLR performs the best overall accuracy (72%), demonstrating a well-balanced sensitivity (62%) and specificity (81%). Conclusions: This study suggested that DBR is a more accurate predictive index for surgical intervention in pediatric adhesive small bowel obstruction patients compared to NLR and PNLR, providing valuable guidance for treatment strategies. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Objetivo: Desarrollar un índice de predicción utilizando datos inflamatorios de laboratorio para identificar qué pacientes podrían necesitar cirugía. Método: Los pacientes se dividieron en dos grupos según su estrategia de manejo: no quirúrgico (grupo 1) o quirúrgico (grupo 2). Resultados: Las bilirrubinas indirecta, directa y total fueron significativamente más altas en el grupo 2 que en el grupo 1 (p = 0.001, p < 0.001 y p < 0.001, respectivamente). Las relaciones neutrófilos-linfocitos, plaquetasneutrófilos- linfocitos y bilirrubina directa-linfocitos fueron significativamente más altas en el grupo 2 que en el grupo 1 (p = 0.041, p = 0.020 y p < 0.001, respectivamente). En el grupo 2, el 78% tenían intestino viable. Se realizó resección en el 40% de los casos, con un 12% de mortalidad y una estancia hospitalaria promedio de 10 días. La relación bilirrubina directa-linfocitos tuvo la mejor precisión general (72%), demostrando una sensibilidad bien equilibrada (62%) y una buena especificidad (81%). Conclusiones: Este estudio sugiere que la relación bilirrubina directa-linfocitos es un índice predictivo más preciso para la intervención quirúrgica en pacientes pediátricos con obstrucción adhesiva de intestino delgado en comparación con la de neutrófilos- linfocitos y la de plaquetas-neutrófilos-linfocitos, proporcionando una valiosa orientación para las estrategias de tratamiento. [ABSTRACT FROM AUTHOR]
Copyright of Cirugía y Cirujanos is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Can direct bilirubin-to-lymphocyte ratio predict surgery for pediatric adhesive small bowel obstruction?
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  Data: &#191;La relaci&#243;n bilirrubina directa-linfocitos puede predecir la cirug&#237;a para la obstrucci&#243;n adhesiva del intestino delgado en ni&#241;os?
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Azizoglu%2C+Mustafa%22&quot;&gt;Azizoglu, Mustafa&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; mdmazizoglu@gmail.com&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Arslan%2C+Serkan%22&quot;&gt;Arslan, Serkan&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kamci%2C+Tahsin+O%2E%22&quot;&gt;Kamci, Tahsin O.&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Basuguy%2C+Erol%22&quot;&gt;Basuguy, Erol&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Aydogdu%2C+Bahattin%22&quot;&gt;Aydogdu, Bahattin&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Karabel%2C+M&#252;semma+A%2E%22&quot;&gt;Karabel, M&#252;semma A.&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Okur%2C+Mehmet+H%2E%22&quot;&gt;Okur, Mehmet H.&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Cirug&#237;a+y+Cirujanos%22&quot;&gt;Cirug&#237;a y Cirujanos&lt;/searchLink&gt;. may/jun2024, Vol. 92 Issue 3, p307-313. 7p.
– Name: Subject
  Label: Subjects
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22BOWEL+obstructions%22&quot;&gt;BOWEL obstructions&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22BILIRUBIN%22&quot;&gt;BILIRUBIN&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22LYMPHOCYTES%22&quot;&gt;LYMPHOCYTES&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22ENTEROHEPATIC+circulation%22&quot;&gt;ENTEROHEPATIC circulation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22BACTEREMIA%22&quot;&gt;BACTEREMIA&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Objective: Estimating which patients might require surgical intervention is crucial. Patients with complete bowel obstructions exhibit disrupted enterohepatic cycles of bile and bacteremia due to bacterial translocation. The goal of this study was to develop a prediction index using laboratory inflammatory data to identify patients who may need surgery. Materials and methods: The patients were divided into two groups based on their management strategy: Non-operative management (Group 1) and surgical management (Group 2). Results: The indirect bilirubin, direct bilirubin, and total bilirubin were significantly higher in Group 2 than in Group 1 (p = 0.001, p &lt; 0.001, and p &lt; 0.001, respectively). The neutrophil-to-lymphocyte ratio (NLR), platelet-to-NLR (PNLR), and direct bilirubin-to-lymphocyte ratio (DBR) were significantly higher in Group 2 compared to Group 1 (p = 0.041, p = 0.020, and p &lt; 0.001, respectively). In group 2, 78% have viable bowels. Resection was performed in 40% of cases, with 12% mortality and a 10-day average hospital stay. DLR performs the best overall accuracy (72%), demonstrating a well-balanced sensitivity (62%) and specificity (81%). Conclusions: This study suggested that DBR is a more accurate predictive index for surgical intervention in pediatric adhesive small bowel obstruction patients compared to NLR and PNLR, providing valuable guidance for treatment strategies. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Objetivo: Desarrollar un &#237;ndice de predicci&#243;n utilizando datos inflamatorios de laboratorio para identificar qu&#233; pacientes podr&#237;an necesitar cirug&#237;a. M&#233;todo: Los pacientes se dividieron en dos grupos seg&#250;n su estrategia de manejo: no quir&#250;rgico (grupo 1) o quir&#250;rgico (grupo 2). Resultados: Las bilirrubinas indirecta, directa y total fueron significativamente m&#225;s altas en el grupo 2 que en el grupo 1 (p = 0.001, p &lt; 0.001 y p &lt; 0.001, respectivamente). Las relaciones neutr&#243;filos-linfocitos, plaquetasneutr&#243;filos- linfocitos y bilirrubina directa-linfocitos fueron significativamente m&#225;s altas en el grupo 2 que en el grupo 1 (p = 0.041, p = 0.020 y p &lt; 0.001, respectivamente). En el grupo 2, el 78% ten&#237;an intestino viable. Se realiz&#243; resecci&#243;n en el 40% de los casos, con un 12% de mortalidad y una estancia hospitalaria promedio de 10 d&#237;as. La relaci&#243;n bilirrubina directa-linfocitos tuvo la mejor precisi&#243;n general (72%), demostrando una sensibilidad bien equilibrada (62%) y una buena especificidad (81%). Conclusiones: Este estudio sugiere que la relaci&#243;n bilirrubina directa-linfocitos es un &#237;ndice predictivo m&#225;s preciso para la intervenci&#243;n quir&#250;rgica en pacientes pedi&#225;tricos con obstrucci&#243;n adhesiva de intestino delgado en comparaci&#243;n con la de neutr&#243;filos- linfocitos y la de plaquetas-neutr&#243;filos-linfocitos, proporcionando una valiosa orientaci&#243;n para las estrategias de tratamiento. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Cirug&#237;a y Cirujanos is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.24875/CIRU.23000524
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      – Code: eng
        Text: English
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        PageCount: 7
        StartPage: 307
    Subjects:
      – SubjectFull: BOWEL obstructions
        Type: general
      – SubjectFull: BILIRUBIN
        Type: general
      – SubjectFull: LYMPHOCYTES
        Type: general
      – SubjectFull: ENTEROHEPATIC circulation
        Type: general
      – SubjectFull: BACTEREMIA
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      – TitleFull: Can direct bilirubin-to-lymphocyte ratio predict surgery for pediatric adhesive small bowel obstruction?
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              M: 05
              Text: may/jun2024
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              Y: 2024
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