REEVALUACIÓN DEL RÓTULO DE ALERGIA A PENICILINA, EL USO ADECUADO DE ANTIBIÓTICOS β-LACTÁMICOS Y LA MULTIRRESISTENCIA.

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Title: REEVALUACIÓN DEL RÓTULO DE ALERGIA A PENICILINA, EL USO ADECUADO DE ANTIBIÓTICOS β-LACTÁMICOS Y LA MULTIRRESISTENCIA.
Alternate Title: Reevaluation of penicillin allergy labeling, appropriate use of β-lactam antibiotics, and multidrug resistance.
Authors: HUAIER ARRIAZU, EMILIO F.1 emilio.huaier@hospitalitaliano.org.ar, NEMIROVSKY, CORINA1, CLARA, LILIANA O.1
Source: Medicina (Buenos Aires). sep/oct2024, Vol. 84 Issue 5, p946-958. 13p.
Abstract (English): Approximately 10% of the population reports being allergic to penicillin, although usually less than 1% really are. In addition, people with proven allergies over the years may no longer be allergic. Unconfirmed penicillin allergy and use of alternative antimicrobials result in more treatment failures; more severe adverse effects. Higher cost; longer hospitalizations; increase in the emergence of multi-resistant germs associated with health care. The risk of cross-allergy between β-lactam groups is usually <2%, depending on the similarity of the side chains, so prescribing antibiotics from another β-lactam group is safe as long as we take into account the structural similarity. Incorporating the reassessment of allergies and improving the prescription of antibiotics in this group of patients reduces the generation and spread of multi-resistant germs, and the associated costs. There are simple methods and specific scores that simplify allergy reassessment. The objective of this review is to expose how, through these methods, the delabeling of patients erroneously labeled as allergic and the safe prescription of β-lactam antibiotics can be achieved. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Aproximadamente el 10% de la población refiere ser alérgico a la penicilina, aunque habitualmente menos del 1% lo es; además las personas con alergia demostrada con el paso de los años pueden dejar de ser alérgicos. La alergia a la penicilina sin confirmación y el uso de antimicrobianos alternativos tienen como efecto más fallas en el tratamiento; más efectos adversos graves; mayor costo; internaciones más prolongadas; incremento en la emergencia de gérmenes multirresistentes asociados a los cuidados de la salud. El riesgo de alergia cruzada entre grupos de β-lactámicos suele ser <2%, dependiendo de la similitud de las cadenas laterales, por lo que prescribir antibióticos de otro grupo de β-lactámicos es seguro siempre que tengamos en cuenta la similitud estructural. Incorporar la reevaluación de alergias y mejorar la prescripción de antibióticos en este grupo de pacientes, disminuye la generación y propagación de gérmenes multirresistentes, y los costos asociados. Existen métodos sencillos y escalas específicas que permiten simplificar la reevaluación de la alergia. El objetivo de esta revisión es exponer cómo a través de estos métodos, puede lograrse el desrotulado de pacientes erróneamente etiquetados como alérgicos y la prescripción segura de antibióticos β-lactámicos. [ABSTRACT FROM AUTHOR]
Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Reevaluation of penicillin allergy labeling, appropriate use of β-lactam antibiotics, and multidrug resistance.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Medicina+%28Buenos+Aires%29%22&quot;&gt;Medicina (Buenos Aires)&lt;/searchLink&gt;. sep/oct2024, Vol. 84 Issue 5, p946-958. 13p.
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  Data: Approximately 10% of the population reports being allergic to penicillin, although usually less than 1% really are. In addition, people with proven allergies over the years may no longer be allergic. Unconfirmed penicillin allergy and use of alternative antimicrobials result in more treatment failures; more severe adverse effects. Higher cost; longer hospitalizations; increase in the emergence of multi-resistant germs associated with health care. The risk of cross-allergy between β-lactam groups is usually &lt;2%, depending on the similarity of the side chains, so prescribing antibiotics from another β-lactam group is safe as long as we take into account the structural similarity. Incorporating the reassessment of allergies and improving the prescription of antibiotics in this group of patients reduces the generation and spread of multi-resistant germs, and the associated costs. There are simple methods and specific scores that simplify allergy reassessment. The objective of this review is to expose how, through these methods, the delabeling of patients erroneously labeled as allergic and the safe prescription of β-lactam antibiotics can be achieved. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
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  Data: Aproximadamente el 10% de la poblaci&#243;n refiere ser al&#233;rgico a la penicilina, aunque habitualmente menos del 1% lo es; adem&#225;s las personas con alergia demostrada con el paso de los a&#241;os pueden dejar de ser al&#233;rgicos. La alergia a la penicilina sin confirmaci&#243;n y el uso de antimicrobianos alternativos tienen como efecto m&#225;s fallas en el tratamiento; m&#225;s efectos adversos graves; mayor costo; internaciones m&#225;s prolongadas; incremento en la emergencia de g&#233;rmenes multirresistentes asociados a los cuidados de la salud. El riesgo de alergia cruzada entre grupos de β-lact&#225;micos suele ser &lt;2%, dependiendo de la similitud de las cadenas laterales, por lo que prescribir antibi&#243;ticos de otro grupo de β-lact&#225;micos es seguro siempre que tengamos en cuenta la similitud estructural. Incorporar la reevaluaci&#243;n de alergias y mejorar la prescripci&#243;n de antibi&#243;ticos en este grupo de pacientes, disminuye la generaci&#243;n y propagaci&#243;n de g&#233;rmenes multirresistentes, y los costos asociados. Existen m&#233;todos sencillos y escalas espec&#237;ficas que permiten simplificar la reevaluaci&#243;n de la alergia. El objetivo de esta revisi&#243;n es exponer c&#243;mo a trav&#233;s de estos m&#233;todos, puede lograrse el desrotulado de pacientes err&#243;neamente etiquetados como al&#233;rgicos y la prescripci&#243;n segura de antibi&#243;ticos β-lact&#225;micos. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Text: Spanish
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      – TitleFull: REEVALUACIÓN DEL RÓTULO DE ALERGIA A PENICILINA, EL USO ADECUADO DE ANTIBIÓTICOS β-LACTÁMICOS Y LA MULTIRRESISTENCIA.
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              M: 09
              Text: sep/oct2024
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