Prevalence and factors associated with sensitivity to methylisothiazolinone in individuals with suspected allergic contact dermatitis: A cross-sectional study.
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| Title: | Prevalence and factors associated with sensitivity to methylisothiazolinone in individuals with suspected allergic contact dermatitis: A cross-sectional study. |
|---|---|
| Alternate Title: | Prevalencia y factores asociados con la sensibilidad a la metilisotiazolinona en individuos con sospecha de dermatitis alérgica por contacto: un estudio transversal. |
| Authors: | Silva Belluco, Paulo Eduardo1 belluco@outlook.com, Maria Birolim, Marcela2, Domingues Ferreira, Maurício3, Feijó Belluco, Júllia Eduarda4, Maciel Azevedo, Fabíola da Silva5, da Mota Pinheiro, Bianca6, Feijó Belluco, Rosana Zabulon1, Santiago Reis, Carmelia Matos1 |
| Source: | Revista Alergia de Mexico. oct-dic2024, Vol. 71 Issue 4, p234-241. 8p. |
| Subjects: | CONTACT dermatitis, DETERGENTS, INDUSTRIAL goods, COSMETICS |
| Geographic Terms: | BRAZIL |
| Abstract (English): | Objectives: To evaluate the prevalence of methylisothiazolinone (MI) sensitivity and associated factors in individuals with suspected allergic contact dermatitis. Methods: Cross-sectional study based on patch tests, including methylisothiazolinone 0.2%, in 286 participants with suspected allergic contact dermatitis, in Brasília/DF, Brazil, between March/2020 and March/2022. Results: 13.6% of participants were diagnosed with allergic contact dermatitis and sensitive to MI. The mean age was 43.7 years, and the majority were women (71,8%). The average duration of the disease was 60 months. The most common location was hands (76.9%) and upper limbs (33.3%). In 97.4%, allergy to methylisothiazolinone was considered of current relevance. In the multivariate model, being domestic/household increased the chance of presenting sensitivity to MI by 4.2 (95% CI= 1.36 - 13.5). Presenting lesions in several places of the body was also significantly associated (OR=2.84; CI 95%=1.17 - 6.86) to be sensitive to the test substance. Conclusion: The findings confirm the epidemic of allergy to methylisothiazolinone. They reinforce the need for the inclusion of this isolated substance in the Brazilian baseline series. We emphasize the need for regulations on the use of methylisothiazolinone in industrial products and household detergents, as is done for cosmetics. Studies in other centers are needed to confirm these results. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Objetivo: Evaluar la prevalencia de sensibilidad a la metilisotiazolinona y los factores asociados en individuos con sospecha de dermatitis alérgica por contacto. Métodos: Estudio transversal, llevado a cabo en pacientes con sospecha de dermatitis alérgica por contacto, a quienes se aplicaron pruebas de parche, incluida la metilisotiazolinona al 0.2%, atendidos en Brasilia/DF, Brasil, entre marzo de 2020 y marzo de 2022. Resultados: Se registraron 286 pacientes con dermatitis alérgica por contacto. El 13.6% de los participantes fueron diagnosticados con dermatitis alérgica de contacto y sensibles a metilisotiazolinona. La edad media fue de 43.7 años y la mayoría fueron mujeres (71.8%). La duración media de la enfermedad fue de 60 meses. La localización más frecuente fueron las manos (76.9%) y los miembros superiores (33.3%). En el 97.4% la alergia a la metilisotiazolinona se consideró de relevancia actual. En el modelo multivariante, ser ama de casa incrementó la probabilidad de padecer sensibilidad a la metilisotiazolinona en 4.2% de los casos (IC95%: 1.36 - 13.5). Manifestar lesiones en diferentes sitios anatómicos también tuvo asociación significativa (OR: 2.84; IC95%: 1.17 - 6.86) de tener sensibilidad a la sustancia de ensayo. Conclusión: Los hallazgos confirman la epidemia de alergia a la metilisotiazolinona. Refuerzan la necesidad de inclusión de esta sustancia aislada en las series de referencia brasileñas. Es importante reglamentar el uso de metilisotiazolinona en productos industriales y detergentes domésticos, como se hace con los cosméticos; por tanto, se requieren estudios adicionales, en otros centros, para confirmar estos resultados. [ABSTRACT FROM AUTHOR] |
| Copyright of Revista Alergia de Mexico is the property of Coleg. Mexicano de Inmunologia Clinica y Alergia A.C.; Soc. Lat. de Alergia, Asma e Inmunologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 181995651 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Prevalence and factors associated with sensitivity to methylisothiazolinone in individuals with suspected allergic contact dermatitis: A cross-sectional study. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Prevalencia y factores asociados con la sensibilidad a la metilisotiazolinona en individuos con sospecha de dermatitis alérgica por contacto: un estudio transversal. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Silva+Belluco%2C+Paulo+Eduardo%22">Silva Belluco, Paulo Eduardo</searchLink><relatesTo>1</relatesTo><i> belluco@outlook.com</i><br /><searchLink fieldCode="AR" term="%22Maria+Birolim%2C+Marcela%22">Maria Birolim, Marcela</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Domingues+Ferreira%2C+Maurício%22">Domingues Ferreira, Maurício</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Feijó+Belluco%2C+Júllia+Eduarda%22">Feijó Belluco, Júllia Eduarda</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Maciel+Azevedo%2C+Fabíola+da+Silva%22">Maciel Azevedo, Fabíola da Silva</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22da+Mota+Pinheiro%2C+Bianca%22">da Mota Pinheiro, Bianca</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Feijó+Belluco%2C+Rosana+Zabulon%22">Feijó Belluco, Rosana Zabulon</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Santiago+Reis%2C+Carmelia+Matos%22">Santiago Reis, Carmelia Matos</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Revista+Alergia+de+Mexico%22">Revista Alergia de Mexico</searchLink>. oct-dic2024, Vol. 71 Issue 4, p234-241. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22CONTACT+dermatitis%22">CONTACT dermatitis</searchLink><br /><searchLink fieldCode="DE" term="%22DETERGENTS%22">DETERGENTS</searchLink><br /><searchLink fieldCode="DE" term="%22INDUSTRIAL+goods%22">INDUSTRIAL goods</searchLink><br /><searchLink fieldCode="DE" term="%22COSMETICS%22">COSMETICS</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22BRAZIL%22">BRAZIL</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Objectives: To evaluate the prevalence of methylisothiazolinone (MI) sensitivity and associated factors in individuals with suspected allergic contact dermatitis. Methods: Cross-sectional study based on patch tests, including methylisothiazolinone 0.2%, in 286 participants with suspected allergic contact dermatitis, in Brasília/DF, Brazil, between March/2020 and March/2022. Results: 13.6% of participants were diagnosed with allergic contact dermatitis and sensitive to MI. The mean age was 43.7 years, and the majority were women (71,8%). The average duration of the disease was 60 months. The most common location was hands (76.9%) and upper limbs (33.3%). In 97.4%, allergy to methylisothiazolinone was considered of current relevance. In the multivariate model, being domestic/household increased the chance of presenting sensitivity to MI by 4.2 (95% CI= 1.36 - 13.5). Presenting lesions in several places of the body was also significantly associated (OR=2.84; CI 95%=1.17 - 6.86) to be sensitive to the test substance. Conclusion: The findings confirm the epidemic of allergy to methylisothiazolinone. They reinforce the need for the inclusion of this isolated substance in the Brazilian baseline series. We emphasize the need for regulations on the use of methylisothiazolinone in industrial products and household detergents, as is done for cosmetics. Studies in other centers are needed to confirm these results. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Objetivo: Evaluar la prevalencia de sensibilidad a la metilisotiazolinona y los factores asociados en individuos con sospecha de dermatitis alérgica por contacto. Métodos: Estudio transversal, llevado a cabo en pacientes con sospecha de dermatitis alérgica por contacto, a quienes se aplicaron pruebas de parche, incluida la metilisotiazolinona al 0.2%, atendidos en Brasilia/DF, Brasil, entre marzo de 2020 y marzo de 2022. Resultados: Se registraron 286 pacientes con dermatitis alérgica por contacto. El 13.6% de los participantes fueron diagnosticados con dermatitis alérgica de contacto y sensibles a metilisotiazolinona. La edad media fue de 43.7 años y la mayoría fueron mujeres (71.8%). La duración media de la enfermedad fue de 60 meses. La localización más frecuente fueron las manos (76.9%) y los miembros superiores (33.3%). En el 97.4% la alergia a la metilisotiazolinona se consideró de relevancia actual. En el modelo multivariante, ser ama de casa incrementó la probabilidad de padecer sensibilidad a la metilisotiazolinona en 4.2% de los casos (IC95%: 1.36 - 13.5). Manifestar lesiones en diferentes sitios anatómicos también tuvo asociación significativa (OR: 2.84; IC95%: 1.17 - 6.86) de tener sensibilidad a la sustancia de ensayo. Conclusión: Los hallazgos confirman la epidemia de alergia a la metilisotiazolinona. Refuerzan la necesidad de inclusión de esta sustancia aislada en las series de referencia brasileñas. Es importante reglamentar el uso de metilisotiazolinona en productos industriales y detergentes domésticos, como se hace con los cosméticos; por tanto, se requieren estudios adicionales, en otros centros, para confirmar estos resultados. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Revista Alergia de Mexico is the property of Coleg. Mexicano de Inmunologia Clinica y Alergia A.C.; Soc. Lat. de Alergia, Asma e Inmunologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.29262/ram.v71i4.1418 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 234 Subjects: – SubjectFull: CONTACT dermatitis Type: general – SubjectFull: DETERGENTS Type: general – SubjectFull: INDUSTRIAL goods Type: general – SubjectFull: COSMETICS Type: general – SubjectFull: BRAZIL Type: general Titles: – TitleFull: Prevalence and factors associated with sensitivity to methylisothiazolinone in individuals with suspected allergic contact dermatitis: A cross-sectional study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Silva Belluco, Paulo Eduardo – PersonEntity: Name: NameFull: Maria Birolim, Marcela – PersonEntity: Name: NameFull: Domingues Ferreira, Maurício – PersonEntity: Name: NameFull: Feijó Belluco, Júllia Eduarda – PersonEntity: Name: NameFull: Maciel Azevedo, Fabíola da Silva – PersonEntity: Name: NameFull: da Mota Pinheiro, Bianca – PersonEntity: Name: NameFull: Feijó Belluco, Rosana Zabulon – PersonEntity: Name: NameFull: Santiago Reis, Carmelia Matos IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: oct-dic2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 00025151 Numbering: – Type: volume Value: 71 – Type: issue Value: 4 Titles: – TitleFull: Revista Alergia de Mexico Type: main |
| ResultId | 1 |
