MORTALIDAD LUEGO DE UNA FRACTURA DE CADERA: SEGUIMIENTO A 10 AÑOS.
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| Title: | MORTALIDAD LUEGO DE UNA FRACTURA DE CADERA: SEGUIMIENTO A 10 AÑOS. |
|---|---|
| Alternate Title: | MORTALITY AFTER HIP FRACTURE: 10-YEAR FOLLOW-UP. |
| Authors: | Vera Santana, María Eugenia1, Pérez, Betiana1, Diehl, María1 mariavera181082@gmail.com, Perman, Gastón2, Beratarrechea, Andrea2, Plantalech, Luisa1 |
| Source: | Actualizaciones en Osteología. ene-abr2024, Vol. 20 Issue 1, p43-57. 15p. |
| Subjects: | MORTALITY risk factors, HIP fractures, DISEASE risk factors, CONGESTIVE heart failure, MULTIVARIATE analysis, SURVIVAL analysis (Biometry) |
| Abstract (English): | Hip fractures due to osteoporosis constitute a health problem and are associated with increased morbidity and mortality. Objective: To determine the rates, causes, and risk factors for mortality in patients with hip fractures over a 10-year follow-up period. Methodology: This retrospective cohort study included patients aged ≥50 years who were part of the health plan at the Italian Hospital of Buenos Aires and were hospitalized for hip fracture between July 1, 2005, and December 31, 2010. Sex, age, comorbidities, and preand post-fracture bisphosphonate treatment were evaluated. Statistical methods included chi-square tests, mean, median, standard deviation, Kaplan-Meier survival analysis, and Cox proportional hazards model. Results: A total of 965 patients were included. The mean age at the time of fracture was 81.6 years, and 80.7% were women. The overall mortality rate at one year was 14.9%, increasing to 73.2% at 10 years. Mortality was higher in men (HR: 1.31; 95% CI 1.10-1.58; p=0.003), older age (HR: 1.10; 95% CI 1.09- 1.11; p<0.001), and Charlson comorbidity score (HR: 1.29; 95% CI 1.23-1.34; p<0.001) at ten years of follow-up. Risk factors for mortality during the study period, according to multivariate Cox analysis, included age, Charlson index, male sex, medial fracture, dementia, and congestive heart failure. Bisphosphonates improved survival (Cox analysis). The most common causes of death were infectious and cardiovascular. Patients that survived after ten years of followup were healthier, younger at baseline, and showed a higher proportion of treatment with bisphosphonates after hip fracture. Conclusions: This long-term observation highlights the importance of follow-up and osteoactive drug treatment after hip fracture, especially in older, male and patients with comorbidities [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Las fracturas de cadera por osteoporosis constituyen un problema de salud y se relacionan con el aumento de la morbimortalidad. Objetivo: determinar las tasas, las causas y factores de riesgo de mortalidad en los pacientes con fracturas de cadera, en un período de seguimiento de 10 años. Metodología: estudio de cohorte, retrospectivo, realizado en pacientes ≥ 50 años pertenecientes al Plan de Salud del Hospital Italiano de Buenos Aires que se internaron por fractura de cadera entre el 01-7-2005 y el 31-12-2010. Se evaluaron: sexo, edad, comorbilidades y tratamiento con bifosfonato prefractura y posfractura. Se utilizaron los métodos: Chi cuadrado, media, mediana y DS, sobrevida de Kaplan-Meier y modelos de riesgo proporcionales de Cox. Resultados: se incluyeron 965 pacientes. La media de edad al momento de la fractura fue 81,6 años; el 80,7% fueron mujeres. La mortalidad global al año fue de 14,9% y de 73,2% a los 10 años, siendo mayor en hombres (HR: 1,31; IC 95%: 1,10-1,58; p=0,003), mayor edad (HR: 1,10; IC 95%: 1,09-1,11; p<0,001) y aumento del puntaje (score) de Charlson (HR:1,29; IC 95%: 1,23-1,34; p<0,001). Los factores de riesgo de mortalidad según el análisis multivariable de Cox en el período son: edad, índice de Charlson, sexo masculino, fractura medial, demencia e insuficiencia cardíaca congestiva. Los bifosfonatos favorecieron la sobrevida de la población (Cox). Las causas de muerte más frecuentes fueron las infecciosas y las cardiovasculares. A los 10 años sobrevivió la población que era más joven al inicio del estudio, más sana y tratada con bifosfonatos después de la fractura de cadera. Conclusiones: de esta observación a largo plazo surge la importancia del seguimiento y tratamiento con fármacos osteoactivos después de la fractura de cadera a toda la población, especialmente a la más añosa, masculina y con comorbilidades. [ABSTRACT FROM AUTHOR] |
| Copyright of Actualizaciones en Osteología is the property of Asociacion Argentina de Osteologia y Metabolismo Mineral and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
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| Items | – Name: Title Label: Title Group: Ti Data: MORTALIDAD LUEGO DE UNA FRACTURA DE CADERA: SEGUIMIENTO A 10 AÑOS. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: MORTALITY AFTER HIP FRACTURE: 10-YEAR FOLLOW-UP. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Vera+Santana%2C+María+Eugenia%22">Vera Santana, María Eugenia</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Pérez%2C+Betiana%22">Pérez, Betiana</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Diehl%2C+María%22">Diehl, María</searchLink><relatesTo>1</relatesTo><i> mariavera181082@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Perman%2C+Gastón%22">Perman, Gastón</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Beratarrechea%2C+Andrea%22">Beratarrechea, Andrea</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Plantalech%2C+Luisa%22">Plantalech, Luisa</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Actualizaciones+en+Osteología%22">Actualizaciones en Osteología</searchLink>. ene-abr2024, Vol. 20 Issue 1, p43-57. 15p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22MORTALITY+risk+factors%22">MORTALITY risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22HIP+fractures%22">HIP fractures</searchLink><br /><searchLink fieldCode="DE" term="%22DISEASE+risk+factors%22">DISEASE risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22CONGESTIVE+heart+failure%22">CONGESTIVE heart failure</searchLink><br /><searchLink fieldCode="DE" term="%22MULTIVARIATE+analysis%22">MULTIVARIATE analysis</searchLink><br /><searchLink fieldCode="DE" term="%22SURVIVAL+analysis+%28Biometry%29%22">SURVIVAL analysis (Biometry)</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Hip fractures due to osteoporosis constitute a health problem and are associated with increased morbidity and mortality. Objective: To determine the rates, causes, and risk factors for mortality in patients with hip fractures over a 10-year follow-up period. Methodology: This retrospective cohort study included patients aged ≥50 years who were part of the health plan at the Italian Hospital of Buenos Aires and were hospitalized for hip fracture between July 1, 2005, and December 31, 2010. Sex, age, comorbidities, and preand post-fracture bisphosphonate treatment were evaluated. Statistical methods included chi-square tests, mean, median, standard deviation, Kaplan-Meier survival analysis, and Cox proportional hazards model. Results: A total of 965 patients were included. The mean age at the time of fracture was 81.6 years, and 80.7% were women. The overall mortality rate at one year was 14.9%, increasing to 73.2% at 10 years. Mortality was higher in men (HR: 1.31; 95% CI 1.10-1.58; p=0.003), older age (HR: 1.10; 95% CI 1.09- 1.11; p<0.001), and Charlson comorbidity score (HR: 1.29; 95% CI 1.23-1.34; p<0.001) at ten years of follow-up. Risk factors for mortality during the study period, according to multivariate Cox analysis, included age, Charlson index, male sex, medial fracture, dementia, and congestive heart failure. Bisphosphonates improved survival (Cox analysis). The most common causes of death were infectious and cardiovascular. Patients that survived after ten years of followup were healthier, younger at baseline, and showed a higher proportion of treatment with bisphosphonates after hip fracture. Conclusions: This long-term observation highlights the importance of follow-up and osteoactive drug treatment after hip fracture, especially in older, male and patients with comorbidities [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Las fracturas de cadera por osteoporosis constituyen un problema de salud y se relacionan con el aumento de la morbimortalidad. Objetivo: determinar las tasas, las causas y factores de riesgo de mortalidad en los pacientes con fracturas de cadera, en un período de seguimiento de 10 años. Metodología: estudio de cohorte, retrospectivo, realizado en pacientes ≥ 50 años pertenecientes al Plan de Salud del Hospital Italiano de Buenos Aires que se internaron por fractura de cadera entre el 01-7-2005 y el 31-12-2010. Se evaluaron: sexo, edad, comorbilidades y tratamiento con bifosfonato prefractura y posfractura. Se utilizaron los métodos: Chi cuadrado, media, mediana y DS, sobrevida de Kaplan-Meier y modelos de riesgo proporcionales de Cox. Resultados: se incluyeron 965 pacientes. La media de edad al momento de la fractura fue 81,6 años; el 80,7% fueron mujeres. La mortalidad global al año fue de 14,9% y de 73,2% a los 10 años, siendo mayor en hombres (HR: 1,31; IC 95%: 1,10-1,58; p=0,003), mayor edad (HR: 1,10; IC 95%: 1,09-1,11; p<0,001) y aumento del puntaje (score) de Charlson (HR:1,29; IC 95%: 1,23-1,34; p<0,001). Los factores de riesgo de mortalidad según el análisis multivariable de Cox en el período son: edad, índice de Charlson, sexo masculino, fractura medial, demencia e insuficiencia cardíaca congestiva. Los bifosfonatos favorecieron la sobrevida de la población (Cox). Las causas de muerte más frecuentes fueron las infecciosas y las cardiovasculares. A los 10 años sobrevivió la población que era más joven al inicio del estudio, más sana y tratada con bifosfonatos después de la fractura de cadera. Conclusiones: de esta observación a largo plazo surge la importancia del seguimiento y tratamiento con fármacos osteoactivos después de la fractura de cadera a toda la población, especialmente a la más añosa, masculina y con comorbilidades. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Actualizaciones en Osteología is the property of Asociacion Argentina de Osteologia y Metabolismo Mineral and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 15 StartPage: 43 Subjects: – SubjectFull: MORTALITY risk factors Type: general – SubjectFull: HIP fractures Type: general – SubjectFull: DISEASE risk factors Type: general – SubjectFull: CONGESTIVE heart failure Type: general – SubjectFull: MULTIVARIATE analysis Type: general – SubjectFull: SURVIVAL analysis (Biometry) Type: general Titles: – TitleFull: MORTALIDAD LUEGO DE UNA FRACTURA DE CADERA: SEGUIMIENTO A 10 AÑOS. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Vera Santana, María Eugenia – PersonEntity: Name: NameFull: Pérez, Betiana – PersonEntity: Name: NameFull: Diehl, María – PersonEntity: Name: NameFull: Perman, Gastón – PersonEntity: Name: NameFull: Beratarrechea, Andrea – PersonEntity: Name: NameFull: Plantalech, Luisa IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: ene-abr2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 16698975 Numbering: – Type: volume Value: 20 – Type: issue Value: 1 Titles: – TitleFull: Actualizaciones en Osteología Type: main |
| ResultId | 1 |
