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Regenerative medicine in surgery: stem cells and exosome applications.

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Title: Regenerative medicine in surgery: stem cells and exosome applications.
Alternate Title: Medicina regenerativa en cirugía: aplicaciones de células madre y exosomas.
Authors: Azizoglu, Mustafa1,2,3,4 (AUTHOR) mdmazizoglu@gmail.com, Zorba-Yildiz, Asli P.4,5 (AUTHOR), Yilmaz, Hazal4 (AUTHOR), Yurtbay, Goncagul4 (AUTHOR), Catli, Gonul4,6 (AUTHOR), Yavuz, Giray4,7 (AUTHOR), Yavas, Arzu D.4,8 (AUTHOR), Eren, Makbule4,9 (AUTHOR), Arici, Merve10 (AUTHOR), Goken, Vedat5 (AUTHOR), Yasar, Selcuk4,11 (AUTHOR), Darici, Hakan12,13,14 (AUTHOR)
Source: Cirugía y Cirujanos. jan/feb2025, Vol. 93 Issue 1, p86-104. 19p.
Subjects: EXTRACELLULAR vesicles, STEM cells, REGENERATIVE medicine, STEM cell treatment, SURGICAL pathology
Abstract (English): This review outlines the role of regenerative medicine in surgical applications, focusing on stem cells and exosomes. Among the most important features of stem cells are their unique ability to differentiate into various cell types, which make them stand out in regeneration and repair. Recent advances highlight the effectiveness of not only these cells themselves but also the exosomes, the nano-sized extracellular vesicles they produce, in this regeneration. On the other hand, exosomes assure additional advantages concerning low immunogenicity and high bioavailability but have raised problems in standardization and safety. In fact, the introduction of these stem cell and exosome technologies is changing the management of surgical pathologies and offering hope for diseases hitherto considered incurable. In this review, the use of stem cell therapies in various surgical diseases is categorized and examined, their clinical importance is emphasized, and the deficiencies in research studies are indicated. Therefore, the results are promising for treatments, but more standardized protocols and expanded research on long-term safety and effectiveness are needed. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Esta revisión describe el papel de la medicina regenerativa en aplicaciones quirúrgicas, enfocándose en células madre y exosomas. Entre las características más importantes de las células madre destaca su capacidad única de diferenciarse en diversos tipos celulares, lo que las hace sobresalir en regeneración y reparación. Los avances recientes resaltan la efectividad no solo de estas células en sí mismas, sino también de los exosomas (las vesículas extracelulares de tamaño nanométrico que producen) en estos procesos de regeneración. Por otro lado, los exosomas ofrecen ventajas adicionales relacionadas con baja inmunogenicidad y alta biodisponibilidad, aunque han planteado problemas en cuanto a estandarización y seguridad. De hecho, la introducción de estas tecnologías de células madre y exosomas está transformando el manejo de patologías quirúrgicas y ofreciendo esperanza para enfermedades hasta ahora consideradas incurables. En esta revisión se categoriza y examina el uso de terapias con células madre en diversas enfermedades quirúrgicas, se enfatiza su importancia clínica y se señalan las deficiencias en los estudios de investigación. Por lo tanto, los resultados son prometedores para los tratamientos, pero se necesitan protocolos más estandarizados y una investigación ampliada sobre la seguridad y efectividad a largo plazo. [ABSTRACT FROM AUTHOR]
Copyright of Cirugía y Cirujanos is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
FullText Text:
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DbLabel: MedicLatina
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PubType: Academic Journal
PubTypeId: academicJournal
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  Group: Ti
  Data: Regenerative medicine in surgery: stem cells and exosome applications.
– Name: TitleAlt
  Label: Alternate Title
  Group: TiAlt
  Data: Medicina regenerativa en cirugía: aplicaciones de células madre y exosomas.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Azizoglu%2C+Mustafa%22">Azizoglu, Mustafa</searchLink><relatesTo>1,2,3,4</relatesTo> (AUTHOR)<i> mdmazizoglu@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Zorba-Yildiz%2C+Asli+P%2E%22">Zorba-Yildiz, Asli P.</searchLink><relatesTo>4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yilmaz%2C+Hazal%22">Yilmaz, Hazal</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yurtbay%2C+Goncagul%22">Yurtbay, Goncagul</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Catli%2C+Gonul%22">Catli, Gonul</searchLink><relatesTo>4,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yavuz%2C+Giray%22">Yavuz, Giray</searchLink><relatesTo>4,7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yavas%2C+Arzu+D%2E%22">Yavas, Arzu D.</searchLink><relatesTo>4,8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Eren%2C+Makbule%22">Eren, Makbule</searchLink><relatesTo>4,9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arici%2C+Merve%22">Arici, Merve</searchLink><relatesTo>10</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Goken%2C+Vedat%22">Goken, Vedat</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yasar%2C+Selcuk%22">Yasar, Selcuk</searchLink><relatesTo>4,11</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Darici%2C+Hakan%22">Darici, Hakan</searchLink><relatesTo>12,13,14</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Cirugía+y+Cirujanos%22">Cirugía y Cirujanos</searchLink>. jan/feb2025, Vol. 93 Issue 1, p86-104. 19p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22EXTRACELLULAR+vesicles%22">EXTRACELLULAR vesicles</searchLink><br /><searchLink fieldCode="DE" term="%22STEM+cells%22">STEM cells</searchLink><br /><searchLink fieldCode="DE" term="%22REGENERATIVE+medicine%22">REGENERATIVE medicine</searchLink><br /><searchLink fieldCode="DE" term="%22STEM+cell+treatment%22">STEM cell treatment</searchLink><br /><searchLink fieldCode="DE" term="%22SURGICAL+pathology%22">SURGICAL pathology</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: This review outlines the role of regenerative medicine in surgical applications, focusing on stem cells and exosomes. Among the most important features of stem cells are their unique ability to differentiate into various cell types, which make them stand out in regeneration and repair. Recent advances highlight the effectiveness of not only these cells themselves but also the exosomes, the nano-sized extracellular vesicles they produce, in this regeneration. On the other hand, exosomes assure additional advantages concerning low immunogenicity and high bioavailability but have raised problems in standardization and safety. In fact, the introduction of these stem cell and exosome technologies is changing the management of surgical pathologies and offering hope for diseases hitherto considered incurable. In this review, the use of stem cell therapies in various surgical diseases is categorized and examined, their clinical importance is emphasized, and the deficiencies in research studies are indicated. Therefore, the results are promising for treatments, but more standardized protocols and expanded research on long-term safety and effectiveness are needed. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Esta revisión describe el papel de la medicina regenerativa en aplicaciones quirúrgicas, enfocándose en células madre y exosomas. Entre las características más importantes de las células madre destaca su capacidad única de diferenciarse en diversos tipos celulares, lo que las hace sobresalir en regeneración y reparación. Los avances recientes resaltan la efectividad no solo de estas células en sí mismas, sino también de los exosomas (las vesículas extracelulares de tamaño nanométrico que producen) en estos procesos de regeneración. Por otro lado, los exosomas ofrecen ventajas adicionales relacionadas con baja inmunogenicidad y alta biodisponibilidad, aunque han planteado problemas en cuanto a estandarización y seguridad. De hecho, la introducción de estas tecnologías de células madre y exosomas está transformando el manejo de patologías quirúrgicas y ofreciendo esperanza para enfermedades hasta ahora consideradas incurables. En esta revisión se categoriza y examina el uso de terapias con células madre en diversas enfermedades quirúrgicas, se enfatiza su importancia clínica y se señalan las deficiencias en los estudios de investigación. Por lo tanto, los resultados son prometedores para los tratamientos, pero se necesitan protocolos más estandarizados y una investigación ampliada sobre la seguridad y efectividad a largo plazo. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Cirugía y Cirujanos is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=183200237
RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.24875/CIRU.24000620
    Languages:
      – Code: eng
        Text: English
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        PageCount: 19
        StartPage: 86
    Subjects:
      – SubjectFull: EXTRACELLULAR vesicles
        Type: general
      – SubjectFull: STEM cells
        Type: general
      – SubjectFull: REGENERATIVE medicine
        Type: general
      – SubjectFull: STEM cell treatment
        Type: general
      – SubjectFull: SURGICAL pathology
        Type: general
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      – TitleFull: Regenerative medicine in surgery: stem cells and exosome applications.
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              M: 01
              Text: jan/feb2025
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              Y: 2025
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